The Disappearance of Acetylsalicylic Acid (ASA) in Aqueous Solution from the Cat Stomach and its Influence on the Transmucosal Ion Transport in the Innervated Non‐secreting Stomach

Abstract

FRENNINC, B. The disappearance of acetylsalicylic acid ( A S A ) in aqueous solutionfrom the cat stomach and its influence o n the transmucosal ion transport in the innervated, non-secreting stomach. Acta physiol. scand. 197 1. 83. 235-246.During instillation of aqueous solutions of acetylsalicylic acid (ASA) into innervated, nonsecreting whole stomach pouches in the cat, parallel decreases in the salicylate and hydrogen

Small intestinal permeability. 1. Effects of ischaemia and exposure to acetyl salicylate.

“…Small intestinal permeability eability to hydrogen, sodium, potassium, and chloride ions. Frenning (1971), studying the increased permeability induced in cat gastric mucosa by ASA, suggested that the effect was produced by a widening of the mucosal intercellular spaces and loosening of the tight junctions.…”

Increased Inulin Absorption from the Gat Stomach Exposed to Acetylsalicylic Acid

“…A single instillation of ASA into the stomach produced a maximal effect on ion permeability within one hr (Davenport 1964, Frenning 1971. ASA escapes rapidly from the gastric lumen , Schanker et al 1957, Davenport 1964); very little remained 1 h after instillation of 6 ml 16.5 mM ASA into the cat stomach (Frenning 1971). I t is possible, however, that it is not only the mean time required for migration across the mucosa, but for the first molecules to get across, which is important, since there may be some t latency due to the time required for the full effect of ASA on saccharide permeability to develop.…”

“…I t is well known that the presence of unionized acetylsalicylic acid (ASA) in the lumen of the stomach increases the ionic permeability of the gastric mucosa (Davenport 1964, 1967, Frenning 1971, Ivey 1971, Smith et al 1971. Some other weak acids exert a similar effect although the concentrations required usually are higher (Davenport 1964, Flemstrom, Frenning and Obrink 1964, Flemstrom and Frenning 1968, Flemstrom 1971.…”

Comparison of Effects of Lysine Aspirin, Soluble Aspirin and Conventional Aspirin on Buccal Potential Difference in Healthy Volunteer Subjects

“…Aspirin is a widely used analgesic well known both for its injurious effects on the gastric mucosa (Caruso & Bianchi Porro, 1980) and its ability to evoke a diversity of allergic reactions in man (Samter & Beers, 1968). The unionized form of the drug in an acid environment increases the ionic permeability of the gastric mucosa (Davenport, 1964;Frenning, 1971). There is convincing evidence that escape of hydrogen ions from the lumen, consequent on the permeability increase, is an important factor in the pathogenesis of mucosal erosions and gastric bleeding (Davenport, 1964(Davenport, , 1967.…”