The Disability Rate of 5-Year Post-Stroke and Its Correlation Factors: A National Survey in China

Yang, Yang; Shi, Yuzhi; Zhang, Ning; Wang, Shuo; Ungvári, Gábor S.; Ng, Chee H.; Wang, Yi Long; Zhao, Xing Quan; Wang, Chun Xue; Xiang, Yu‐Tao

doi:10.1371/journal.pone.0165341

Cited by 84 publications

(71 citation statements)

References 39 publications

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“…According to Yang et al . (2016) in China, about 45% of stroke survivors have a disability consistent with the range of 36–71% reported in similar research from both Sweden (Jonsson et al . 2014) and Australia (Hankey et al .…”

Section: Introductionsupporting

confidence: 87%

Do caregivers’ personality and emotional intelligence modify their perception of relationship and communication with people with aphasia?

Kroll

Karakiewicz

2020

Intl J Lang & Comm Disor

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Background There is a wide agreement that family and friends of people with aphasia (PWA) can play a crucial role in the rehabilitation of interpersonal communication. Therefore, speech and language therapists (SLTs) should include family and friends in the process of therapy. However, little has been said about the role of caregivers of severely disabled PWA in the rehabilitation of communication functions. Aims To examine how caregivers of severely disabled PWA perceive their relationship and communication with PWA, how they facilitate communication with PWA, and whether the caregiver's personality and emotional intelligence modify the abovementioned processes. Methods & Procedures The study involved 123 caregivers of severely disabled stroke survivors with aphasia. Participants took part in a structured interview based on a structured interview guide created for the purpose of this study. The standardized psychological questionnaires NEO Five‐Factor Inventory (NEO‐FFI) and Schutte Emotional Intelligence Scale (SEIS) were used. Outcomes & Results The caregiver's positive attitude towards the PWA correlated with the active facilitation of communication. The personality traits of caregivers and their level of emotional intelligence were associated with the tendency to use certain techniques to facilitate communication with PWA. Conclusions & Implications Caregivers’ positive attitude towards PWA is beneficial for the rehabilitation of communicative functions. Personality traits and emotional intelligence could modify the caregiver's strategy of coping with aphasia‐related challenges and should be taken into consideration when providing support.

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Section: Introductionsupporting

confidence: 87%

Do caregivers’ personality and emotional intelligence modify their perception of relationship and communication with people with aphasia?

Kroll

Karakiewicz

2020

Intl J Lang & Comm Disor

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“…An apparent challenge in the management of stroke is neuropsychiatric sequelae, which dramatically reduce stroke survivors’ quality of life . While a large proportion of stroke survivors have physical disability, approximately 20%–30% of stroke patients experience poststroke depression (PSD) and cognitive impairment . Although various rehabilitative therapies have been introduced to the treatment of poststroke neuropsychiatric sequelae, the effectiveness is unsatisfactory and suboptimal .…”

mentioning

confidence: 99%

Assessor‐ and participant‐blinded, randomized controlled trial of dense cranial electroacupuncture stimulation plus body acupuncture for neuropsychiatric sequelae of stroke

Zhang

Zhao

Jin

et al. 2019

Psychiatry Clin Neurosci

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Aim Acupuncture has benefits in the rehabilitation of neuropsychiatric sequelae of stroke. This study was aimed to evaluate the effectiveness of dense cranial electroacupuncture stimulation plus body acupuncture (DCEAS+BA) in treating poststroke depression (PSD), functional disability, and cognitive deterioration. Methods In this assessor‐ and participant‐blinded, randomized controlled trial, 91 stroke patients who initially had PSD were randomly assigned to either DCEAS+BA (n = 45) or minimum acupuncture stimulation as controls (n = 46) for three sessions per week over 8 consecutive weeks. The primary outcome was baseline‐to‐end‐point change in score of the 17‐item Hamilton Depression Rating Scale. Secondary outcomes included the Montgomery–Åsberg Depression Rating Scale for depressive symptoms, the Barthel Index for functional disability, and the Montreal Cognitive Assessment for cognitive function. Results DCEAS+BA‐treated patients showed strikingly greater end‐point reduction than MAS‐treated patients in scores of the three symptom domains. The clinical response rate, defined as an at least 50% baseline‐to‐end‐point reduction in 17‐item Hamilton Depression Rating Scale score, was markedly higher in the DCEAS+BA‐treated group than that of controls (40.0% vs 17.4%, P = 0.031). Incidence of adverse events was not different in the two groups. Subgroup analysis revealed that DCEAS+BA with electrical stimulation on forehead acupoints was more apparent in reducing Barthel‐Index‐measured disability than that without electrical stimulation. Conclusion DCEAS+BA, particularly with electrical stimulation on forehead acupoints, reduces PSD, functional disability, and cognitive deterioration of stroke patients. It can serve as an effective rehabilitation therapy for neuropsychiatric sequelae of stroke.

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“…If the severity of depression is not distinguished and is collectively referred to as PSD, the incidence is 20-70%. 10 The above studies show that ischemic stroke can cause depression.…”

Section: Ischemic Stroke Causes Depressionmentioning

confidence: 93%

Death-associated Protein Kinase 1 Impairs the Hippocampo-prefrontal Cortical Circuit and Mediates Post-stroke Depression

Ke¹,

Ma²,

Zhang³

et al. 2018

Exploratory Research and Hypothesis in Medicine

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Post-stroke depression (PSD) is a common and complex post-stroke neuropsychiatric disorder, which not only delays functional recovery but also increases mortality, and which currently lacks effective drug therapy. The pathogenesis of PSD is associated with impairment of the subcortical neural circuits and alterations of synaptic plasticity and neurotransmitters, but the exact mechanisms of PSD remain unknown. Our previous work indicates that the death-associated protein kinase 1 (DAPK1) mediates neuronal death after stroke. Genetic deletion of DAPK1 gene or blocking DAPK1 signal in the PSD mouse model can not only alleviate cerebral ischemic injury but also relieve PSD-like behaviors. Our previous work has also demonstrated the following results. First, the neural circuit of dorsal CA1 (dCA1) to medial prefrontal cortex (mPFC) (dCA1-mPFC) is selectively impaired after stroke. Second, the DAPK1 signal is involved in the impairment of dCA1-mPFC neural circuit after stroke. Third, genetic deletion of the DAPK1 gene or blocking of the DAPK1 signal alleviates the injury of dCA1-mPFC neural circuit after stroke and improves PSD-like behaviors. In conclusion, we hypothesize that activated DAPK1 signal after stroke induces apoptosis in the hippocampal dCA1 neurons, leading to loss of the dCA1-mPFC glutamatergic projections, synaptic injury, decrease of glutamate release, inhibition of mPFC neurons, and finally onset of PSD. We hope to further replenish the mechanisms of PSD and provide new insights for PSD treatment.

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The Disability Rate of 5-Year Post-Stroke and Its Correlation Factors: A National Survey in China

Cited by 84 publications

References 39 publications

Do caregivers’ personality and emotional intelligence modify their perception of relationship and communication with people with aphasia?

Do caregivers’ personality and emotional intelligence modify their perception of relationship and communication with people with aphasia?

Assessor‐ and participant‐blinded, randomized controlled trial of dense cranial electroacupuncture stimulation plus body acupuncture for neuropsychiatric sequelae of stroke

Death-associated Protein Kinase 1 Impairs the Hippocampo-prefrontal Cortical Circuit and Mediates Post-stroke Depression

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