The Disabilities Caused by Hypophysectomy and Their Repair

Smith, Philip E.

doi:10.1001/jama.1927.02680290020005

Cited by 346 publications

(58 citation statements)

References 7 publications

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“…Hypophysectomy of the rat causes a depression of spermatogenesis (Smith 1927(Smith , 1930 and produces a testis, at 32 days post-hypophysectomy, that contains mainly early primary spermatocytes, spermatogonia and Sertoli cells (Elkington et al 1973;Elkington and Blackshaw 1974). After hypophysectomy there was a fall in total LDH-X activity at 8 days, which coincided with the initial depression in primary spermatocyte and spermatid numbers.…”

Section: Discussionmentioning

confidence: 99%

Studies on Testicular Function III. Effects of FSH, LH, Testosterone and Dihydrotestosterone on Restoration and Maintenance of Testicular-Specific Lactate Dehydrogenase Activity in the Hypophysectomized Rat

Elkington¹,

Blackshaw²

1974

Aust. Jnl. Of Bio. Sci.

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Hypophysectomy of the adult male rat depressed the activity of testicular-specific lactate dehydrogenase (LDH-X). Groups of rats were treated with FSH (F), LH (L) or testosterone (T) alone or in combination after 32 days of post-hypophysectomy regression (restoration experiment) for a further 32 days or with F, T or dihydrotestosterone (D) alone or in combination from 2 days after hypophysectomy (maintenance experiment) for 30 days.LDH-X activity per milligram of protein was restored to normal by the hormonal combinations FT and LT while F, L, or T given alone or the FL and FLT combinations were ineffective. However, the total LDH-X activity per testis was only partially restored by the hormonal combinations FT, LT and FLT.In the maintenance experiment LDH-X activity per milligram of protein was maintained by all hormonal treatments except D, while the total LDH-X activity per testis was completely maintained by the FT hormonal combination. All other hormonal treatments except F alone maintained the activity of this isoenzyme above the level in the hypophysectomized rat.The restoration and maintenance of LDH-X activity in the testis of the hypophysectomized rat was successful with those combinations of hormones that were also able to restore or maintain the numbers of late primary spermatocytes and spermatids. Thus, the level of LDH-X activity in the testis is dependent on the presence of late primary spermatocytes and spermatids and hence this enzyme is a good marker for the production of these cells in the rat testis.

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Section: Discussionmentioning

confidence: 99%

Studies on Testicular Function III. Effects of FSH, LH, Testosterone and Dihydrotestosterone on Restoration and Maintenance of Testicular-Specific Lactate Dehydrogenase Activity in the Hypophysectomized Rat

Elkington¹,

Blackshaw²

1974

Aust. Jnl. Of Bio. Sci.

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“…Confirmation was supp1ied by Bai1ey and Bremer (1921) who produced obesity in dogs by making sma11 cuts at the base of the brain which did not damage the hypophysis. This finding was subsequent1y rep1icated in rats by Smith (1927) and 1ater by Hetherington and Ranson (1940). The latter investigators then demonstrated that destruction of the ventromedia1 nucleus of the hypothalamus (VMH) was responsib1e for the obesity (Hetherington, 1944).…”

Section: The Ro1e Of the Hypothalamus In Feeding Behaviormentioning

confidence: 91%

Effect of hippocampal stimulation on feeding in the rat

Milgram¹

1969

Physiology & Behavior

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“…This was demonstrated by the facts that, one, injection of pituitary extract would suppress reproductive cyclicity (54); and two, hypophysectomy would result in atrophy of the reproductive system and cessation of estrous cycles. Injections of pituitary extracts resulted in reversal of the atrophy (193). Thus (89).…”

mentioning

confidence: 93%