The direct role of vitamin D on bone homeostasis

St‐Arnaud, René

doi:10.1016/j.abb.2008.03.038

Cited by 138 publications

(111 citation statements)

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“…52 There is also recent and growing evidence that vitamin D has direct effects on bone cells through its interaction with specific vitamin D receptors. [53][54][55][56][57] These actions are not completely characterized but appear to include anabolic effects on osteoblast differentiation, proliferation and mineralization, as well as stimulatory effects on osteoclast precursors to enhance cellular adhesion. Taken together, these effects act to significantly increase bone turnover as measured by such markers as serum osteocalcin and bone-specific alkaline phosphatase and urinary N-telopeptide of type I collagen.…”

Section: Impact Of Bariatric Surgery On Bone Metabolismmentioning

confidence: 99%

Bariatric surgery and bone disease: from clinical perspective to molecular insights

et al. 2012

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Section: Impact Of Bariatric Surgery On Bone Metabolismmentioning

confidence: 99%

Bariatric surgery and bone disease: from clinical perspective to molecular insights

et al. 2012

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“…Vitamin D exerts its action at a cellular level through binding of the active metabolite 1,25-dihydroxyvitamin D to the vitamin D receptor (VDR). The VDR is expressed in many different cell types such as pancreatic b cells (1), vascular smooth muscle cells (2), and osteoblasts and chondrocytes (3). Several polymorphisms in the gene encoding the VDR, such as Cdx2, FokI, BsmI, ApaI, and TaqI, have been demonstrated to be related to bone characteristics and risk of fractures, although results remain equivocal (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals

Jongh

Lips

Rijs

et al. 2011

European Journal of Endocrinology

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Context: Vitamin D receptor (VDR) polymorphisms are associated with a variety of diseases, which may translate into an effect on mortality. Objective: To investigate the associations between VDR gene variants and mortality among older people. Design: The analyses were conducted in a population-based, prospective cohort of the Longitudinal Aging Study Amsterdam. Adequate DNA analysis was performed in 923 men and women (R65 years). We aimed to assess the associations between mortality and the VDR polymorphism FokI, three haplotypes of the Cdx2 and GATA polymorphisms, and three haplotypes of the BsmI, ApaI, and TaqI polymorphisms. Results: During the median follow-up of 10.7 years, 480 participants deceased (51%). Homozygosity for the Cdx2-GATA haplotype 1 allele was associated with a 30% higher mortality risk compared to the absence of alleles (hazard ratios (HR) 1.30, 95% confidence intervals (CI) 1.01-1.68). Adjustment for cardiovascular risk factors and 25-hydroxyvitamin D levels did not affect this HR. The number of copies of the Cdx2-GATA haplotype 1 allele was associated, although not significantly, with an increased risk of osteoporotic fractures (0 copiesZreference, HR, 95% CI: 1 copy 2.01, 0.99-4.07 and 2 copies 1.81, 0.87-4.18). After adjustment for osteoporotic fractures, homozygosity for the Cdx2-GATA haplotype 1 allele was no longer associated with higher mortality risk (HR 1.08, 95% CI 0.83-1.41).

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“…1,2 This nonclassical effect of vitamin D 3 is additional to the more classical role of vitamin D 3 on the mineral-calcium metabolism in bone. 3,4 Clinical studies suggest (somewhat inconsistently) that elevated vitamin D 3 levels can lower arterial blood pressure. 5 However, there is a strong correlation between insufficient serum levels of vitamin D 3 that are observed in heart failure, myocardial infarction and elevation of arterial blood pressure.…”

Section: Introductionmentioning

confidence: 99%

“…There is a large body of observational data that links vitamin D 3 active metabolite 1,25-dihydroxy vitamin D 3 to the function of the cardiovascular system. 1,2 This nonclassical effect of vitamin D 3 is additional to the more classical role of vitamin D 3 on the mineral-calcium metabolism in bone.…”

Section: Introductionmentioning

confidence: 99%

“…The study presented here uses nanomedical methods of measurement and analysis to elucidate the role of 1,25-dihydroxy vitamin D 3 (abbreviated as vitamin D 3 throughout the text) in the stimulation of NO and ONOO − . Normal and angiotensin II (Ang II)-induced dysfunctional human umbilical vein endothelial cells (HUVECs) of African Americans (AAs) and Caucasian Americans (CAs) were used in this study.…”

Section: Introductionmentioning

confidence: 99%

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Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional endothelium by 1,25-dihydroxy vitamin D<sub>3</sub> – clinical implications for cardiovascular diseases

Khan¹,

Dawoud²,

Maliński³

2018

IJN

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Background Clinical studies indicate that vitamin D 3 improves circulation and may have beneficial effects in hypertension. This study uses nanomedical systems to investigate the role of 1,25-dihydroxy vitamin D 3 in the preservation/restoration of endothelial function in an angiotensin II (Ang II) cellular model of hypertension. Methods 1,25-dihydroxy vitamin D 3 -stimulated nitric oxide (NO) and peroxynitrite (ONOO − ) concentrations were measured in situ with nanosensors (200–300 mm diameter with a detection limit of 1 nM) in human umbilical vein endothelial cells of African American (AA) and Caucasian American (CA) donors exposed to Ang II. The balance/imbalance between NO and ONOO − concentrations ([NO]/[ONOO − ]) was simultaneously monitored and used as an indicator of endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction. Results [NO]/[ONOO − ] imbalance in Ang II-stimulated dysfunctional endothelium was 0.20±0.16 for CAs and 0.11±0.09 for AAs. Uncoupled eNOS and overexpression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase contributed to high production of ONOO − . Vitamin D 3 treatment reversed [NO]/[ONOO − ] to 3.0±0.1 in CAs and 2.1±0.1 in AAs – exceeding that observed in normal endothelium. Vitamin D 3 restored uncoupled eNOS and endothelial function by increasing cytoprotective NO and decreasing the cytotoxic ONOO − . The beneficial effect of vitamin D 3 is associated with a favorable rate of NO and ONOO − release, restoration of the [NO]/[ONOO − ] and the overall decrease in the overexpression of eNOS, inducible nitric oxide synthase and NADPH oxidase. This effect of vitamin D 3 may prove to be beneficial in the treatment of hypertension and other cardiovascular diseases, including heart failure, myocardial infarction, vasculopathy, stroke and diabetes.

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The direct role of vitamin D on bone homeostasis

Cited by 138 publications

References 65 publications

Bariatric surgery and bone disease: from clinical perspective to molecular insights

Bariatric surgery and bone disease: from clinical perspective to molecular insights

Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals

Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional endothelium by 1,25-dihydroxy vitamin D<sub>3</sub> – clinical implications for cardiovascular diseases

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The direct role of vitamin D on bone homeostasis

Cited by 138 publications

References 65 publications

Bariatric surgery and bone disease: from clinical perspective to molecular insights

Bariatric surgery and bone disease: from clinical perspective to molecular insights

Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals

Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional endothelium by 1,25-dihydroxy vitamin D<sub>3</sub> &ndash; clinical implications for cardiovascular diseases

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Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional endothelium by 1,25-dihydroxy vitamin D<sub>3</sub> – clinical implications for cardiovascular diseases