2008
DOI: 10.1016/j.abb.2008.03.038
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The direct role of vitamin D on bone homeostasis

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Cited by 138 publications
(111 citation statements)
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“…52 There is also recent and growing evidence that vitamin D has direct effects on bone cells through its interaction with specific vitamin D receptors. [53][54][55][56][57] These actions are not completely characterized but appear to include anabolic effects on osteoblast differentiation, proliferation and mineralization, as well as stimulatory effects on osteoclast precursors to enhance cellular adhesion. Taken together, these effects act to significantly increase bone turnover as measured by such markers as serum osteocalcin and bone-specific alkaline phosphatase and urinary N-telopeptide of type I collagen.…”
Section: Impact Of Bariatric Surgery On Bone Metabolismmentioning
confidence: 99%
“…52 There is also recent and growing evidence that vitamin D has direct effects on bone cells through its interaction with specific vitamin D receptors. [53][54][55][56][57] These actions are not completely characterized but appear to include anabolic effects on osteoblast differentiation, proliferation and mineralization, as well as stimulatory effects on osteoclast precursors to enhance cellular adhesion. Taken together, these effects act to significantly increase bone turnover as measured by such markers as serum osteocalcin and bone-specific alkaline phosphatase and urinary N-telopeptide of type I collagen.…”
Section: Impact Of Bariatric Surgery On Bone Metabolismmentioning
confidence: 99%
“…Vitamin D exerts its action at a cellular level through binding of the active metabolite 1,25-dihydroxyvitamin D to the vitamin D receptor (VDR). The VDR is expressed in many different cell types such as pancreatic b cells (1), vascular smooth muscle cells (2), and osteoblasts and chondrocytes (3). Several polymorphisms in the gene encoding the VDR, such as Cdx2, FokI, BsmI, ApaI, and TaqI, have been demonstrated to be related to bone characteristics and risk of fractures, although results remain equivocal (4)(5)(6).…”
Section: Introductionmentioning
confidence: 99%
“…1,2 This nonclassical effect of vitamin D 3 is additional to the more classical role of vitamin D 3 on the mineral-calcium metabolism in bone. 3,4 Clinical studies suggest (somewhat inconsistently) that elevated vitamin D 3 levels can lower arterial blood pressure. 5 However, there is a strong correlation between insufficient serum levels of vitamin D 3 that are observed in heart failure, myocardial infarction and elevation of arterial blood pressure.…”
Section: Introductionmentioning
confidence: 99%
“…There is a large body of observational data that links vitamin D 3 active metabolite 1,25-dihydroxy vitamin D 3 to the function of the cardiovascular system. 1,2 This nonclassical effect of vitamin D 3 is additional to the more classical role of vitamin D 3 on the mineral-calcium metabolism in bone.…”
Section: Introductionmentioning
confidence: 99%
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