The direct depressant effects of desflurane and sevoflurane on spontaneous contractions of isolated gravid rat myometrium

Doğru, Kudret; Dalgiç, H.; Yildiz, Karamehmet; Sezer, Zafer; Madenoğlu, Halit

doi:10.1016/s0959-289x(03)00010-4

Cited by 8 publications

(4 citation statements)

References 17 publications

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“…In vitro studies have shown that sevoflurane and desflurane depress myometrial contraction equally. 12,13 In the present study, blood loss with 3% desflurane or 1% sevoflurane was comparable to that with regional anaesthesia. Desflurane at a concentration of 2 -4% has been shown to produce satisfactory analgesia for vaginal delivery without excessive uterine bleeding.…”

Section: Desflurane and Sevoflurane In Caesarean Sectionsupporting

confidence: 55%

The Maternal and Neonatal Effects of the Volatile Anaesthetic Agents Desflurane and Sevoflurane in Caesarean Section: A Prospective, Randomized Clinical Study

et al. 2006

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This study compared maternal and neonatal outcomes in women undergoing elective caesarean section under general anaesthesia with desflurane or sevoflurane; the neonatal effects were also compared with those in women undergoing epidural anaesthesia. Fifty women requesting general anaesthesia were randomly assigned to receive either 3% desflurane or 1% sevoflurane. Twenty-five women requesting regional anaesthesia received epidural anaesthesia with ropivacaine. Comparing desflurane sevoflurane with respect to their maternal haemodynamic effects, maternal blood pressure levels were higher and tachycardia was more frequent in the desflurane group. Comparing general and epidural anaesthesia, no significant differences were detected in terms of neonatal Apgar scores or neurological adaptive capacity scores. In conclusion, 3% desflurane or 1% sevoflurane for general anaesthesia and ropivacaine for epidural anaesthesia for elective caesarean section had similar effects on neonatal outcomes. In women who received desflurane, blood pressure and heart rate elevation were significantly higher than in the sevoflurane group, though this difference did not have any clinical importance.

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Section: Desflurane and Sevoflurane In Caesarean Sectionsupporting

confidence: 55%

The Maternal and Neonatal Effects of the Volatile Anaesthetic Agents Desflurane and Sevoflurane in Caesarean Section: A Prospective, Randomized Clinical Study

et al. 2006

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“…Animal and experimental studies have demonstrated that volatile anesthetics can cause significant uterine relaxation [ 3 , 10 ]. In a rat model, Dogru et al [ 10 ] showed that desflurane at a minimum alveolar concentration (MAC) of 0.5 did not affect the duration or amplitude of spontaneous uterine contractions, but decreased their frequency. At 1 and 2 MAC, desflurane significantly decreased the duration, amplitude and frequency of uterine contractions.…”

Section: Discussionmentioning

confidence: 99%

Association between anesthetic method and postpartum hemorrhage in Korea based on National Health Insurance Service data

et al. 2022

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Background: Postpartum hemorrhage (PPH) is a major cause of maternal mortality. An increasing incidence of PPH has been reported in many countries. The risk factors for PPH differ among studies and it can occur in patients with no known risk factors. In this large-scale study, we investigated whether the anesthetic method used was associated with PPH after cesarean section.Methods: We extracted data on cesarean sections performed between January 2008 and June 2013 from the National Health Insurance Service database. The anesthetic methods were categorized into general, spinal and epidural anesthesia. To compare the likelihood of PPH among deliveries using different anesthetic methods, crude and adjusted odds ratios (ORs) and 95% confidence intervals were calculated using logistic regression analysis.Results: Data from 330,324 cesarean sections were analyzed, and 21,636 cases of PPH were identified. Univariate analysis showed that general and epidural anesthesia increased the risk of PPH compared to spinal anesthesia. The OR for PPH was highest for morbidly adherent placenta, followed by placenta previa, placental abruption, and hypertension. When other clinical covariates were controlled for, general and epidural anesthesia still remained significant risk factors for PPH compared to spinal anesthesia.Conclusions: This study showed that general and epidural anesthesia elevated the risk of PPH compared to spinal anesthesia during cesarean section. Since we could not consider the potential bias of group differences in indications, more in-depth clinical trials are needed to validate our findings. Obstetric factors such as placental abnormalities had high odds ratios and thus are more important than the choice of anesthetic method, which should be based on the patient’s clinical condition and institutional resources.

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“…218 The use of newer halogenated volatile anesthetics, desflurane and sevoflurane, have been observed to inhibit oxytocin-induced myometrial contractions in the gravid rat in a dose-dependent manner, starting at 0.5 and 1.0 MAC respectively. 219,220 In considering regional techniques, the concern for block failure has encouraged some authors to recommend the CSE technique. 221 Strategies for the management of incomplete epidural anesthesia have included the use of lidocaine 2%, often augmented with other agents; additional sedation and general anesthesia were needed in 13.9% and 2.9% of cases respectively.…”

Section: Anesthesia For Cesarean Deliverymentioning

confidence: 99%

What’s new and novel in obstetric anesthesia? Contributions from the 2003 scientific literature

Tsen

2005

International Journal of Obstetric Anesthesia

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The direct depressant effects of desflurane and sevoflurane on spontaneous contractions of isolated gravid rat myometrium

Cited by 8 publications

References 17 publications

The Maternal and Neonatal Effects of the Volatile Anaesthetic Agents Desflurane and Sevoflurane in Caesarean Section: A Prospective, Randomized Clinical Study

The Maternal and Neonatal Effects of the Volatile Anaesthetic Agents Desflurane and Sevoflurane in Caesarean Section: A Prospective, Randomized Clinical Study

Association between anesthetic method and postpartum hemorrhage in Korea based on National Health Insurance Service data

What’s new and novel in obstetric anesthesia? Contributions from the 2003 scientific literature

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