Abstract:Autophagy is an essential cellular process that eliminates cellular debris, dysfunctional organelles and misfolded proteins thereby maintaining cellular metabolism and homeostasis. Functional autophagy is generally thought to counteract aging and is crucial for the prolonged lifespan and health of an animal. Whereas this statement is true for young animals, we have recently shown that autophagy becomes dysfunctional in post-reproductive C. elegans contributing to aging and neurodegeneration. Downregulation of … Show more
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