The dinucleotide microsatellite polymorphism of the IFNAR1 gene promoter correlates with responsiveness of hepatitis C patients to interferon

Matsuyama, Noriko; Mishiro, Shunji; Sugimoto, Masanobu; Furuichi, Yasuhiro; Hashimoto, Michie; Hijikata, Makoto; Ohta, Yasuhiko

doi:10.1016/s1386-6346(02)00269-3

Cited by 42 publications

(37 citation statements)

References 5 publications

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“…This result was consistent with that of Matsuyama et al [11] . Hence only the -408C/T, -3C/T and GT repeat dinucleotide microsatellite polymorphisms were included in the statistical analysis.…”

Section: Resultssupporting

confidence: 94%

“…Recently, Muldoon et al [10] reported two single nucleotide polymorphisms (SNPs) and one GT repeat dinucleotide microsatellite polymorphism within the promoter region of the IFNAR1 gene. Matsuyama et al [11] reported that the GT repeat dinucleotide microsatellite polymorphism was associated with a difference in antiviral responsiveness to IFN in patients with hepatitis C. This study suggested that the genetic polymorphisms of the IFNAR1 gene affect the immune-specifi c response to IFN-␣ . The present study is the fi rst to investigate whether genetic polymorphisms of the IFNAR1 affect the susceptibility to IFN-induced depression.…”

Section: Introductionmentioning

confidence: 85%

“…The authors investigated four promoter polymorphisms of the IFNAR1 gene: two SNPs and one GT repeat dinucleotide microsatellite polymorphism reported by Muldoon et al [10] , and one SNP reported by Matsuyama et al [11] . Figure 1 shows partial nucleotide sequences of the IFNAR1 gene (GenBank accession number X60459) that include the polymorphisms investigated in this study.…”

Section: Genotypingmentioning

confidence: 99%

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Promoter Polymorphisms of the Interferon-α Receptor Gene and Development of Interferon-Induced Depressive Symptoms in Patients with Chronic Hepatitis C: Preliminary Findings

et al. 2005

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Background: Interferon (IFN)-α treatment frequently induces depression, which can impair quality of life and reduce treatment adherence. Defining relevant risk factors for IFN-α-induced depression is essential for designing preventative treatment strategies. Objective: The purpose of the present study was to determine whether promoter polymorphisms of –408C/T, –3C/T and GT repeat dinucleotide microsatellite in the IFN-α/β receptor 1 (IFNAR1) gene are associated with the development of IFN-induced depression. Method: Fifty patients with chronic hepatitis C were treated with pegylated IFN α-2b plus a standard or weight-based dose of ribavirin. Severity of depression was assessed using the Zung Self-Rating Depression Scale (SDS) at baseline and at 4, 8, 12 and 24 weeks of treatment. Result: The baseline to maximum difference in the SDS index score of neurovegetative/somatic symptoms was higher in patients with the 5/14 genotype of the GT repeat dinucleotide microsatellite polymorphism than in those patients with other genotypes (p = 0.0084). Conclusion: This preliminary result suggests that the promoter GT repeat dinucleotide microsatellite polymorphism of the IFNAR1 gene may represent a risk factor for the development of depressive symptoms during IFN-α therapy for hepatitis C and other conditions.

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Section: Resultssupporting

confidence: 94%

Section: Introductionmentioning

confidence: 85%

Section: Genotypingmentioning

confidence: 99%

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Promoter Polymorphisms of the Interferon-α Receptor Gene and Development of Interferon-Induced Depressive Symptoms in Patients with Chronic Hepatitis C: Preliminary Findings

et al. 2005

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“…Nevertheless, this information provides additional support for a relationship between host genetics and HCV viral clearance and is consistent with several recent reports that evaluated gene expression and gene polymorphisms in individuals with and without sustained virological response to interferon-based regimens (49)(50)(51)(52)(53)(54). Using microarrays in hepatic tissue, Chen and colleagues identified a number of interferon-sensitive genes that correlated with response to antiviral therapy (50).…”

Section: Discussionsupporting

confidence: 81%

Hemophilic Siblings With Chronic Hepatitis C: Familial Aggregation of Spontaneous and Treatment-Related Viral Clearance

et al. 2006

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“…Viral factors, including pre-treatment HCV RNA load, HCV genotype, liver cirrhosis, and host factors, including gender, age, innate immunity, and genetic variation in Interleukin-28B (IL28b) are beneficial in predicting response to interferon (7,8). Several viral factors may predict the outcome of Peg-IFNα-2a/RBV combination therapy; for instance, 40 amino acids in the non-structural 5A (NS5A) region (9,10), and amino acid substitutions in the core region have been reported as predictors of hepatitis C therapy outcome (11,12).…”

Section: Introductionmentioning

confidence: 99%

Genetic Variation in Interleukin-28B and Response to Peg-IFNα-2a/RBV Combination Therapy in Patients with Hepatitis C Virus Infection

Bokharaei‐Salim

Salehi‐Vaziri

Sadeghi

et al. 2016

Jundishapur J Microbiol

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Background: The hepatitis C virus (HCV) infection is one of the major causes of progressive liver diseases worldwide. Despite the new treatments for HCV infection, antiviral therapy with a combination of pegylated interferon-α 2a plus ribavirin (Peg-IFNα-2a/RBV) is still used in developing countries. Objectives: The aim of the current study was to determine the relationship between rs12979860 polymorphism in the interleukin 28B gene (IL28B) and response to Peg-IFNα-2a/RBV combination therapy in Azerbaijani patients with chronic HCV infection. Methods: A total of 72 Azerbaijani patients with established chronic HCV-1b took part in this cross-sectional study between January 2010 and September 2015. Genomic DNA was extracted from peripheral blood mononuclear cells (PBMCs) of the patients and the rs12979860 single nucleotide polymorphism was diagnosed by polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP).

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The dinucleotide microsatellite polymorphism of the IFNAR1 gene promoter correlates with responsiveness of hepatitis C patients to interferon

Cited by 42 publications

References 5 publications

Promoter Polymorphisms of the Interferon-α Receptor Gene and Development of Interferon-Induced Depressive Symptoms in Patients with Chronic Hepatitis C: Preliminary Findings

Promoter Polymorphisms of the Interferon-α Receptor Gene and Development of Interferon-Induced Depressive Symptoms in Patients with Chronic Hepatitis C: Preliminary Findings

Hemophilic Siblings With Chronic Hepatitis C: Familial Aggregation of Spontaneous and Treatment-Related Viral Clearance

Genetic Variation in Interleukin-28B and Response to Peg-IFNα-2a/RBV Combination Therapy in Patients with Hepatitis C Virus Infection

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