2020
DOI: 10.1001/jamacardio.2020.1329
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The Dilemma of Coronavirus Disease 2019, Aging, and Cardiovascular Disease

Abstract: 8. Wirtz H, Hasenclever D, Schwabe K, et al. ACE inhibitor for lung protection during mechanical ventilation for acute lung injury-results of the double-blind, placebo controlled, randomised ACEmeVENT pilot study.

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Cited by 189 publications
(191 citation statements)
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“…[45] It is unfortunate that all of the included studies did not provide report on diabetic or hypertensive medications. Furthermore, the link between those specific variables could be in line with the hypothesis of AlGhatrif et al [46] Older hypertensive individuals have lower ACE2 levels but a higher RAS signalling, this difference is further expressed in COVID-19 patients in which ACE2 developed into a critically low levels and RAS signalling is exaggerated even more. Such disturbance result in a potentially decreased susceptibility to the disease, but a greater severity.…”
Section: Discussionsupporting
confidence: 81%
“…[45] It is unfortunate that all of the included studies did not provide report on diabetic or hypertensive medications. Furthermore, the link between those specific variables could be in line with the hypothesis of AlGhatrif et al [46] Older hypertensive individuals have lower ACE2 levels but a higher RAS signalling, this difference is further expressed in COVID-19 patients in which ACE2 developed into a critically low levels and RAS signalling is exaggerated even more. Such disturbance result in a potentially decreased susceptibility to the disease, but a greater severity.…”
Section: Discussionsupporting
confidence: 81%
“…Diaz [2] supports his recommendation on the basis of the analysis of 1099 Chinese patients infected with SARS-CoV-2, reporting more severe outcome, including death, in patients suffering from cardiovascular and kidney disorders and diabetes, that "most likely" were treated with ARBs. However, analysis of this report [2,6] revealed that the study did not address the use of ARBs in these patients. Data for previous ARB use in patients later infected with SARS-CoV-2, compared with frequency of ARB use in the general population suffering from cardiovascular disorders is not currently available.…”
Section: Dear Editormentioning
confidence: 86%
“…The statement that children may be protected from SARS-CoV-2 infection because their ACE2 is reduced with respect to that of the elderly is erroneous; ACE2 protein and enzymatic activity decline postnatally [3]. More importantly, in the elderly there is lower ACE2 expression and enhanced Angiotensin II proinflammatory effects [6]. This information supports the hypothesis of a protective effect of ARBs in older https://doi.org/10.1016/j.phrs.2020.104832 Received 23 March 2020…”
Section: Dear Editormentioning
confidence: 99%
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