The Digestion of Proteins in Vivo

Nasset, E. S.; Schwartz, Pearl; Weiss, H.

doi:10.1093/jn/56.1.83

Cited by 52 publications

(16 citation statements)

References 6 publications

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“…The hematocrit values were determined on Subject 6. With a value of 42 in the fasting sample, the level decreased progressively to 39 at seven hours, and rose to 40 at eight hours. A drop in hematocrit from 42 to 39 represents an increase of 5 per cent in plasma volume.…”

Section: E Other Analytical Datamentioning

confidence: 89%

The Levels of Individual Free Amino Acids in the Plasma of Normal Man at Various Intervals After a High-Protein Meal1

Frame¹

1958

J. Clin. Invest.

145

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Section: E Other Analytical Datamentioning

confidence: 89%

The Levels of Individual Free Amino Acids in the Plasma of Normal Man at Various Intervals After a High-Protein Meal1

Frame¹

1958

J. Clin. Invest.

145

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“…The decrease in concentration of food protein is similar to that for the enzymatic activity. Nasset, Schwartz, and Weiss (27) Figure 1). This fact must indicate that the enzymes are partly inactivated or autodigested in the lumen of the small intestine.…”

Section: Concentration Of Fat Glucose and Protein In The Intestinal mentioning

confidence: 99%

Studies of Intestinal Digestion and Absorption in the Human1

Borgström¹,

Dahlqvist²,

Lundh³

et al. 1957

J. Clin. Invest.

994

294

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“…The endogenous protein is derived from gastric, pancreatic, and intestinal secretions and from cell desquamation (12). During protein deficiency the endogenous protein is reduced (30,31) because of decreased pancreatic enzyme secretion (32) and decreased gastrointestinal cell turnover rate (6 Our findings demonstrate that the intestinal cell utilizes amino acids absorbed from the lumen to a greater degree than those supplied by a systemic route. The difference between the jejunal and ileal morphology in animals fed a protein-free diet might be directly related to this finding.…”

Section: First Experimentsmentioning

confidence: 83%

Protein starvation and the small intestine

Hirschfield¹,

Kern²

1969

J. Clin. Invest.

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A B ST RA CT Weanling rats were fed diets which contained either no protein or 27% protein. In one experiment after 23-35 days both groups were given l-leucine-4,5-3H either intragastrically or intraperitoneally and then sacrificed 24 hr later. In a second experiment animals were given these diets for 21 days and sacrificed 3, 6, or 12 hr after either intragastric or intraperitoneal administration of the labeled leucine. In both experiments the intestinal mucosa of proximal and distal segments of the small intestine was scraped, weighed, the protein concentration measured, and the specific activty of the mucosal protein was determined.The wet weight of the mucosa and the protein concentration of the mucosa were significantly greater in the control animals than in the protein-depleted animals. The mucosal protein per 100 g of body weight was the same in the protein-deprived and the control groups. The specific activity of the intestinal mucosal protein was higer in the protein-deprived animals than in the control animals.In the protein-deprived animals the proximal segment incorporated more radioactive amino acid into mucosal protein than did the distal segment at 3, 6, 12, and 24 hr after the amino acid was given by mouth. A similar difference was found between the proximal and distal segments of the control animals 6 hr after oral adminisstration of l-leucine-'H. On the other hand, when the l-leucine-3H was given intraperitoneally to both groups

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The Digestion of Proteins in Vivo

Cited by 52 publications

References 6 publications

The Levels of Individual Free Amino Acids in the Plasma of Normal Man at Various Intervals After a High-Protein Meal1

The Levels of Individual Free Amino Acids in the Plasma of Normal Man at Various Intervals After a High-Protein Meal1

Studies of Intestinal Digestion and Absorption in the Human1

Protein starvation and the small intestine

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