The Diffusion of Ferritin Within the Peripheral Nerve Sheath

Waggener, John D.; Bunn, S. M.; Beggs, John L.

doi:10.1097/00005072-196507000-00005

Cited by 97 publications

(16 citation statements)

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“…There is good evidence that the perineurium serves to isolate the axons from the general extracellular fluid pool of the body (Krnjevic, 1954;Waggener, Bunn, and Beggs, 1965;Shantha and Bourne, 1968;Olsson and Reese, 1971), maintaining the axons within a special endoneurial micro-environment the integrity of which is further defended by the restricted permeability ofthe endoneurial capillary (Olsson, 1966). The periaxonal diffusion barrier described above would maintain an even more circumscribed ionic environment around the individual node, separate even from the microenvironment of the endoneurial space.…”

Section: Discussionmentioning

confidence: 99%

Effects of hyperkalaemia on the excitability of peripheral nerve

Seneviratne

Peiris

Weerasuriya

1972

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY An experimental animal model has been developed for the study of excitability change in peripheral nerve during limb ischaemia. This model has been used to investigate the effects of hyperkalaemia on the sequence of excitability change that occurs during cuff-induced limb ischaemia and in the post-ischaemic recovery period. The results lend support to the hypothesis that the dynamics of K ion concentration in the periaxonal space play a critical role in determining these excitability changes and that the polyanionic mucopolysaccharide gap substance of the node of Ranvier is likely to constitute the diffusion barrier that defines the periaxonal space.

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Section: Discussionmentioning

confidence: 99%

Effects of hyperkalaemia on the excitability of peripheral nerve

Seneviratne

Peiris

Weerasuriya

1972

Journal of Neurology, Neurosurgery & Psychiatry

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“…Most of these studies described such vesicles in perineurium and blood vessels (Akert et al, 1976;Hall and Williams, 1971;Olsson and Reese, 1971;Reale et al, 1975;Sandri et al, 1977;Waggener et al, 1965), although a single report described them in SC (Mugnaini et al, 1977). Using an affinity-purified anticaveolin-1 pAb to stain SN, SC and abaxonal myelin are strongly immunostained, with additional staining of the perineurium and blood vessels (Figs.…”

Section: Caveolin-1 Localization In Rat Snmentioning

confidence: 99%

“…Plasma membrane invaginations with the morphologic appearance of caveolae are present in blood vessels (Olsson and Reese, 1971), cells forming the perineurial sheaths of the PNS (Akert et al, 1976;Hall and Williams, 1971;Olsson and Reese, 1971;Reale et al, 1975;Sandri et al, 1977;Waggener et al, 1965), and SC (Mugnaini et al, 1977). However, caveolin expression within SC has not been explored.…”

Section: Introductionmentioning

confidence: 99%

Caveolin‐1 expression in Schwann cells

Mikol

Hong

Cheng

et al. 1999

Glia

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Caveolae are non‐clathrin‐coated invaginations of the plasma membrane, which are present in most cell types. An integral component of caveolae is the caveolin family of related proteins, which not only forms the structural framework of caveolae, but also likely subserves its functional roles, including regulation of signal transduction and cellular transport, in particular, cholesterol trafficking. Although caveolae have been identified ultrastructurally in the peripheral nervous system (PNS), caveolin expression has not previously been studied. To date, three caveolin genes have been reported. Here, we show for the first time that caveolin‐1 is expressed by Schwann cells (SC) as well as several SC‐derived cell lines. Caveolin‐1 is enriched in the buoyant, detergent‐insoluble membranes of rat sciatic nerve (SN) and SC, a hallmark of the caveolar compartment. Caveolin‐1 exists as both soluble and insoluble forms in rat SN and SC, and localizes to SC cytoplasm and abaxonal myelin. SC caveolin‐1 decreases after axotomy, when SC revert to a premyelinating phenotype. We speculate that caveolin‐1 may regulate signal transduction and/or cholesterol transport in myelinating SC. GLIA 27:39–52, 1999. © 1999 Wiley‐Liss, Inc.

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“…The cell layers are separated from each other by an extracellular space which is packed with collagen fibrils aligned longitudinally or obliquely. The perineurium protects the funiculus from mechanical stimuli and acts as a diffusion barrier to substances with specific permeability, such as protein [9,12,14]. The inside of the funiculus is kept in optimum condition by the perineurium which protects the nerve from toxic or infective factors [6].…”

Section: Introductionmentioning

confidence: 99%

Regeneration of perineurium after nerve injury and autografting

Hirasawa

Saiki

Nakao

et al. 1994

International Orthopaedics

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Regeneration of the perineurium after crush injury to the rat sciatic nerve and after autografting was studied in an experimental model. After injury, fibroblast-like cells formed compartments inside the funiculus which gradually acquired the characteristics of the perineurial cell. After grafting, the pattern of perineural regeneration depended on the degree of Schwann cell damage. In the graft and distal nerve trunk the epineurium degenerated and disappeared and new perineural tissue was formed by endoneurial fibroblasts from the inside of the funiculus. At the suture line, fibroblasts encircled the regenerating axons and the Schwann cells to form new compartments resulting in a large number of minifasciles of regenerating nerve. The function of the perineurium as a diffusion barrier was restored satisfactorily in the crushed nerve, although there was no satisfactory repair at 30 weeks after nerve grafting.

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The Diffusion of Ferritin Within the Peripheral Nerve Sheath

Cited by 97 publications

References 0 publications

Effects of hyperkalaemia on the excitability of peripheral nerve

Effects of hyperkalaemia on the excitability of peripheral nerve

Caveolin‐1 expression in Schwann cells

Regeneration of perineurium after nerve injury and autografting

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