The differentiation status of primary gonadal germ cell tumors correlates inversely with telomerase activity and the expression level of the gene encoding the catalytic subunit of telomerase

Schrader, Mark; Burger, Angelika M.; Müller, Markus; Krause, Hans; Straub, Bernd F.; Schostak, Martin; Schulze, Wolfgang; Lauke, Heidrun; Miller, Kurt

doi:10.1186/1471-2407-2-32

Cited by 13 publications

(8 citation statements)

References 42 publications

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“…SPRY4 responds to KIT inhibition by imatinib [396]. TERT and its transcription factor ATF7IP influence telomere maintenance (normally only active in germ cells) [397,398]. The TERT-CLPTM1L locus is a cancer-hotspot ( [149] for review) and CLPTM1L is involved in cisplatin sensitization [399].…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

An oncofetal and developmental perspective on testicular germ cell cancer

Rijlaarsdam

Looijenga

2014

Seminars in Cancer Biology

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Section: Environmental Risk Factorsmentioning

confidence: 99%

An oncofetal and developmental perspective on testicular germ cell cancer

Rijlaarsdam

Looijenga

2014

Seminars in Cancer Biology

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“…, 2002b). Moreover, it has been observed that undifferentiated TGCTs (seminomas) exhibit the pattern of high TERT expression, high telomerase activity and long telomeres seen in normal testicular germ cells, while well‐differentiated TGCTs such as teratomas show minimal TERT expression and no telomerase activity (Schrader et al. , 2002a,b).…”

Section: Tgct Predisposition Loci Identified Via Genome‐wide Associatmentioning

confidence: 99%

Genome‐wide association studies provide new insights into the genetic basis of testicular germ‐cell tumour

Turnbull

Rahman

2011

Int J of Andrology

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Testicular germ-cell tumour (TGCT) is the most common cancer in young men, and genetic epidemiological studies suggest that the disease has a strong genetic basis. Until 2009, very little of this genetic component had been explained. Genome-wide association studies have since identified eight SNPs at six loci which together account for approximately 15% of the genetic risk of TGCT and offer novel biological insights into testicular germ-cell oncogenesis. In this review, we summarize the genetic epidemiology of TGCT, detail the contribution genome-wide association studies have made to our understanding of the genetic basis of TGCT and reflect on how future technological advances may assist in revealing the remaining genetic factors underlying TGCT susceptibility.

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“…Though TERT is expressed during embryonal development, it is usually absent in somatic cells (Greenberg et al ., ), and upregulation of TERT expression is one of the hallmarks of cancer (Jafri et al ., ). In TGCT, the expression of TERT and activity of telomerase activity are high in seminomas, while teratomas show intermediate expression of TERT (Schrader et al ., ). Jia et al .…”

Section: Telomerase Activitymentioning

confidence: 97%

Functions of genes related to testicular germ cell tumour development

2019

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Objective: Testicular germ cell tumour (TGCT) is a malignancy with a high heritable component. The inherited risk is polygenic, and around 50 susceptibility genes are identified. The functional role of the gene products for TGCT development is not well understood. The focus of this review is functional studies of genetic risk factors for TGCT derived from GCNIS and the signalling pathways involved in the pathogenesis. Recent developments: Genome-wide association studies have identified new risk loci for TGCT and confirmed previously identified susceptibility genes. Many of these risk genes are related to male germ cell development, sex determination and genomic integrity. Gain-and loss-of-function studies in animal models and TGCT cell lines, as well as gene and protein expression studies in TGCT patient samples, have contributed to the understanding of TGCT development. KITLG-KIT signalling is of crucial importance, but several other signal transduction pathways may also play a role. Many of the risk loci are in non-coding regions, and studies have revealed that non-coding RNAs may act as oncogenes or tumour suppressors in TGCT development. Conclusions: The risk of TGCT is polygenic, and the underlying molecular mechanisms are complex. Several signalling pathways are related to TGCT development, and both proteins and non-coding RNAs may act as oncogenes or tumour suppressors. Epigenetic studies are of importance to get further knowledge about how the signalling pathways are regulated. Hypermethylation of the 5' CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis. Br J Cancer 92, 760-769. Manuylov NL, Fujiwara Y, Adameyko II, Poulat F & Tevosian SG. (2007) The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models. Dev Biol 307, 356-367.

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The differentiation status of primary gonadal germ cell tumors correlates inversely with telomerase activity and the expression level of the gene encoding the catalytic subunit of telomerase

Cited by 13 publications

References 42 publications

An oncofetal and developmental perspective on testicular germ cell cancer

An oncofetal and developmental perspective on testicular germ cell cancer

Genome‐wide association studies provide new insights into the genetic basis of testicular germ‐cell tumour

Functions of genes related to testicular germ cell tumour development

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