The Differentially Expressed Genes of Human Sporadic Cerebral Cavernous Malformations

Lin, Xiangjiang; Meng, Guolu; Xing, Lingxiao; Yu, Ting; Bai, Chuanfeng; Fei, Xiaobin; Deng, Shengze; Zhao, Jizong; Ren, Shulin; Zhang, Junting; Wu, Zhen; Wang, Shuo; Zhang, Jianguo; Zhang, Liwei

doi:10.1016/j.wneu.2018.02.002

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…Previous studies on the differential transcriptome of resected CCM lesions were performed on the whole lesional tissue, which includes many cell types (10,11). However, experimental evidence supports that CCM physiopathology arises primarily in endothelium (5,12).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes

Koskimäki

Girard

et al. 2019

JCI Insight

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Section: Introductionmentioning

confidence: 99%

Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes

Koskimäki

Girard

et al. 2019

JCI Insight

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“…For NUMR, some genes related to hair follicle development and growth were found in the window that explained the highest proportion of variance, located on ECA7; these are listed as candidates: RHOG [52], UCP2 [53], UCP3 [54] and IL18BP [55]. Although this trait has not been associated with behavior, some of the genes found also exhibit neuropsychiatric actions: RHOG [56], UCP2 [57], and UCP3 [58].…”

Section: Discussionmentioning

confidence: 99%

Genomic Regions Associated with the Position and Number of Hair Whorls in Horses

Lima

Cruz

Pereira

et al. 2021

Animals

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The position and number of hair whorls have been associated with the behavior, temperament, and laterality of horses. The easy observation of whorls assists in the prediction of reactivity, and thus permits the development of better measures of handling, training, mounting, and riding horses. However, little is known about the genetics involved in the formation of hair whorls. Therefore, the aim of this study was to perform a genome-wide association analysis to identify chromosome regions and candidate genes associated with hair whorl traits. Data from 342 Quarter Horses genotyped for approximately 53,000 SNPs were used in an association study using a single-step procedure. The following traits were analyzed: vertical position of hair whorl on the head, number of whorls on the head, and number of whorls on the left and right sides of the neck. The traits had between one and three genomic windows associated. Each of them explained at least 4% of the additive variance. The windows accounted for 20–80% of additive variance for each trait analyzed. Many of the prospected genes are related to hair follicle growth. Some of these genes exert a pleiotropic effect on neurological and behavioral traits. This is the first indication of biological and physiological activity that might explain the association of hair whorls and temperament.

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“…Diesen können allerdings auch vererbte Mutationen zugrunde liegen. Bekannte Assoziationen betreffen die Gene KIRT1, MGC4607, PDCD10 [8]. Häufig stellen Kavernome Zufallsbefunde dar.…”

Section: Introductionunclassified

Elektrokonvulsionstherapie bei einer Patientin mit Kavernom in der Medulla oblongata

Kozian

Grözinger²,

Graf³

2020

Fortschr Neurol Psychiatr

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ZusammenfassungDie Durchführung einer EKT-Behandlung sollte auch beim Vorliegen eines Kavernoms der Medulla oblongata mit früherer Blutung nicht grundsätzlich ausgeschlossen werden, erfordert aber entsprechende Voraussetzungen wie neurochirurgische Konsultation, ein striktes Blutdruckmonitoring und eine besondere Information des Patienten. Summary: Cavernous malformation in the medulla oblongata with previous bleeding is not in principle a reason for excluding electroconvulsive therapy. However, before such intervention is carried out, certain preconditions should be met such as neurosurgical consultation, close blood pressure monitoring and a special medical information of the patient.

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The Differentially Expressed Genes of Human Sporadic Cerebral Cavernous Malformations

Cited by 4 publications

References 43 publications

Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes

Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes

Genomic Regions Associated with the Position and Number of Hair Whorls in Horses

Elektrokonvulsionstherapie bei einer Patientin mit Kavernom in der Medulla oblongata

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