The differential expression of oestrogen receptors, progesterone receptors, Bcl‐2 and Ki67 in endometrial polyps

Taylor, L.J.; Jackson, Tracy L; Reid, Janet G.; Duffy, Sean

doi:10.1111/j.1471-0528.2003.02098.x

Cited by 100 publications

(55 citation statements)

References 16 publications

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“…This suggests that expression of Ki-67 was more sensitive in reflecting the rate of cell proliferation in PCa tissues, which is similar to previous reports. 14,15 The Ki-67 antigen is useful for identifying proliferative cells. Although flow cytometry methods showed that Ki-67 is expressed in all cell cycle phases except G0 phase, its detection by immunohistochemical methods is limited to its appearance in the late G1 phase with maximum expression in prophasis and metaphases.…”

Section: Discussionmentioning

confidence: 99%

Ki-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia

Zhong¹,

Peng²,

He³

et al. 2008

CIM

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Clin Invest Med 2008; 31 (1): E8-E15. AbstractObjective: Ki-67 is a proliferation-associated nuclear antigen and is expressed in all cycling cells except for resting cells in the G0-phase. PCNA is an acidic nuclear protein and has been recognized as a histologic marker for the G1/ S phase in the cell cycle. Ki-67and PCNA labeling indices are considered to reflect cell proliferation, particularly, growth fraction. The purpose of this study is to investigate the expression levels of Ki-67 and PCNA in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) and their potential on the early diagnosis of PCa. Methods: Human prostate cancer cell lines LNCaP and PC-3, human normal prostate epithelial cell line HuPEC, tissues from patients with PCa (121 cases) and BPH (45) and 36 normal cases were examined for the expression of Ki-67 and PCNA by Reverse Transcription-Polymerase Chain Reaction (RT-PCR). Then, the association of Ki-67 and PCNA expression with clinical grading of PCa was analyzed by immunohistochemistry staining. Results: The ratios of PCNA and Ki-67 expression levels in LNCaP and PC-3 were higher (P<0.05, P<0.001) than that in HuPEC. The two markers were differentially expressed in three tissues and showed increased expression in PCa (P<0.05) and BPH (P<0.05), relative to human normal prostate tissues. Compared with BPH, the ratio of Ki-67 and PCNA expressed in tumour tissue was increased (P<0.05). The increase of Ki-67 was greater than that of PCNA. Expression of the two markers increased after different grading of PCa cases Prostate cancer (PCa) is the second most frequent cause of male cancer-related death in the United States of America (USA) and Western Europe. Its incidence is continuously rising, with over 200 000 new cancers and 35 000~40 000 deaths per year, 1 Carcinogenesis and the mechanisms influencing the progression and prognosis of PCa is a multistep process, involving both genetic insults to epithelial cells and changes in epithelial-stromal interactions. 2 Despite extensive research PCa is not understood.There are two proliferative markers-Ki-67 and proliferating cell nuclear antigen (PCNA). Ki-67 antigen is expressed in proliferative cells throughout the G1, S, G2, and M phases, and provides a reliable index of cellular proliferation 3,4 PCNA is an acidic nuclear protein, expressed mainly in phase S of the cellular cycle. It becomes active, in various tissues par-

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Section: Discussionmentioning

confidence: 99%

Ki-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia

Zhong¹,

Peng²,

He³

et al. 2008

CIM

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“…Los pólipos endometriales se originarían en la capa basal del endometrio y sus receptores serían similares a los de esta capa y sensibles por lo tanto, a la acción de los estrógenos y de la progesterona (Kurman et al). Se ha postulado que los pólipos podrían ser el resultado de una alteración cuantitativa a nivel de los receptores de estrógeno (RE) y de progesterona (RP) (Maia et al,1998;Mittal et al,1996;Taylor et al, 2003).…”

Section: Introductionunclassified

“…Se observó la presencia en el útero de receptores de estrógenos en sus dos isoformas alfa y beta (Artega et al,1998;Taylor et al;Critchley et al, 2001), llegándose a la conclusión que el principal receptor es el isoforma alfa. …”

Section: Introductionunclassified

Estudio inmunocitoquímico de Receptores de Estrógeno Fracción Alfa y de Progesterona en Pólipos Endometriales

et al. 2005

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“…Os pólipos endometriais são, portanto, caracterizados por aberrações de regiões especificas do cromossomo, as quais provavelmente envolvem genes relacionados ao processo proliferativo (Speleman F et al, 1991;Dal Cin P et al, 1992;Vanni R et al, 1995;Taylor LJ et al, 2003). A progressão de hiperplasia simples para complexa e, depois, para atípica, demora muitos anos e, possivelmente, depende de acúmulo de aberrações genéticas específicas.…”

Section: Valor Preditivo Positivounclassified

“…Essas alterações genéticas favorecem o crescimento do câncer por impedirem apoptose e, subsequentemente, por afetarem a regulação do "turnover" celular. A hipertensão também é um fator de risco estabelecido para pólipo endometrial com aspecto histológico pré-maligno e maligno (Vanni R et al,1995;Mertens et al, 2002;Taylor LJ et al, 2003).…”

Section: Valor Preditivo Positivounclassified

Correlação ultrassonográfica e histeroscópica no diagnóstico de pólipos endometriais em mulheres na pós-menopausa

Borges¹

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Correlação ultrassonográfica e histeroscópica no diagnóstico de pólipos endometriais em mulheres na pós-menopausaDissertação apresentada ao Programa de Pós-Graduação em Ginecologia, Obstetrícia e Mastologia -Área de Concentração em Ginecologia -Faculdade de Medicina de Botucatu -UNESP, para obtenção de Titulo de Mestre em Ginecologia. Orientador: Professor Adjunto/ Livre Docente Rogério Dias Botucatu -SP 2010

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The differential expression of oestrogen receptors, progesterone receptors, Bcl‐2 and Ki67 in endometrial polyps

Abstract: Objective To obtain a greater understanding of the pathogenesis of endometrial polyps and to gain insight into which factors play a pivotal role in their growth. Design Retrospective analysis of archived paraffin-embedded specimens.

Cited by 100 publications

References 16 publications

Ki-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia

Ki-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia

Estudio inmunocitoquímico de Receptores de Estrógeno Fracción Alfa y de Progesterona en Pólipos Endometriales

Correlação ultrassonográfica e histeroscópica no diagnóstico de pólipos endometriais em mulheres na pós-menopausa

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