The differential effects of OX1R and OX2R selective antagonists on morphine conditioned place preference in naïve versus morphine-dependent mice

Tabaeizadeh, Mohammad; Motiei-Langroudi, Rouzbeh; Mirbaha, Hilda; Esmaeili, Behnaz; Tahsili-Fahadan, Pouya; Javadi‐Paydar, Mehrak; Ghaffarpour, Majid; Dehpour, Ahmad Reza

doi:10.1016/j.bbr.2012.09.010

Cited by 38 publications

(13 citation statements)

References 43 publications

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“…In tests of conditioned place preference (CPP) following pairing with drug administration, VTA injection of OX-A during conditioning induces morphine CPP in a dose-dependent manner [121], and peripheral administration of the OX1R antagonist SB-334867 or OX2R antagonist TCS-OX2-29 suppresses its acquisition and expression [122, 123]. While morphine CPP may be perpetuated by OX binding at OX1R or OX2R, ethanol CPP appears to be mediated more by OX2R.…”

Section: Role In Rewardmentioning

confidence: 99%

Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior

Barson

Morganstern

Leibowitz

2013

International Journal of Endocrinology

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Transcribed within the lateral hypothalamus, the neuropeptides orexin/hypocretin (OX) and melanin-concentrating hormone (MCH) both promote palatable food intake and are stimulated by palatable food. While these two neuropeptides share this similar positive relationship with food, recent evidence suggests that this occurs through different albeit complementary effects on behavior, with OX promoting food seeking and motivation for palatable food and MCH functioning during ongoing food intake, reinforcing the consumption of calorically dense foods. Further differences are evident in their effects on physiological processes, which are largely opposite in nature. For example, activation of OX receptors, which is neuronally excitatory, promotes waking, increases energy expenditure, and enhances limbic dopamine levels and reward. In contrast, activation of MCH receptors, which is neuronally inhibitory, promotes paradoxical sleep, enhances energy conservation, reduces limbic dopamine, and increases depressive behavior. This review describes these different effects of the neuropeptides, developing the hypothesis that they stimulate the consumption of palatable food through excessive seeking in the case of OX and through excessive energy conservation in the case of MCH. It proposes that OX initiates food intake and subsequently stimulates MCH which then acts to prolong the consumption of palatable, energy-dense food.

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Section: Role In Rewardmentioning

confidence: 99%

Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior

Barson

Morganstern

Leibowitz

2013

International Journal of Endocrinology

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“…However, far fewer studies have examined HCRT-2 signaling in drug-seeking/taking behavior in general, and in opioidseeking/taking in particular. Recent research has demonstrated that selective HCRT-R2 antagonism (TCS-OX2-29) blocks the expression of morphine conditioned place preference (Tabaeizadeh et al, 2013). To date, the degree to which HCRT-R2 signaling contributes to self-administration of heroin specifically, and under extended access conditions in particular, has yet to be determined.…”

Section: Introductionmentioning

confidence: 99%

Hypocretin Receptor 2 Antagonism Dose-Dependently Reduces Escalated Heroin Self-Administration in Rats

Schmeichel

Barbier

Misra

et al. 2014

Neuropsychopharmacol

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The hypocretin/orexin (HCRT) system has been associated with both positive and negative drug reinforcement, implicating HCRT receptor 1 (HCRT-R1) signaling in drug-related behaviors for all major drug classes, including opioids. However, to date there are limited studies investigating the role of HCRT receptor 2 (HCRT-R2) signaling in compulsive-like drug seeking. Escalation of drug intake with extended access has been suggested to model the transition from controlled drug use to compulsive-like drug seeking/taking. The current study examined the effects of a HCRT-R2 antagonist, NBI-80713, on heroin self-administration in rats allowed short-(1 h; ShA) or long-(12 h; LgA) access to intravenous heroin self-administration. Results indicate that systemically administered NBI-80713 dose-dependently decreased heroin self-administration in LgA, but not in ShA, animals. Quantitative PCR analyses showed an increase in Hcrtr2 mRNA levels in the central amygdala, a stress-related brain region, of LgA rats. These observations suggest a functional role for HCRT-R2 signaling in compulsive-like heroin self-administration associated with extended access and indicate HCRT-R2 antagonism as a potential pharmacological target for the treatment of heroin dependence.

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“…By contrast, systemic administration of the OX2R antagonist TCS-OX2-29 was unable to attenuate reinstatement of extinguished responding for cocaine (Smith et al, 2009) and had no impact on cue-induced reinstatement of ethanol seeking (Brown et al, 2013). Adding complexity to the OX2r function, the same OXr2 antagonist significantly suppressed acquisition and expression of conditioned place preference to morphine in naïve and dependent mice (Tabaeizadeh et al, 2013), indicating that more studies are needed to clarify the specific OXr2 involvement in compulsive drug intake.…”

Section: The Orexin Systemmentioning

confidence: 88%

Do Orexins contribute to impulsivity-driven binge consumption of rewarding stimulus and transition to drug/food dependence?

Alcaraz-Iborra

Cubero

2015

Pharmacology Biochemistry and Behavior

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The differential effects of OX1R and OX2R selective antagonists on morphine conditioned place preference in naïve versus morphine-dependent mice

Cited by 38 publications

References 43 publications

Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior

Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior

Hypocretin Receptor 2 Antagonism Dose-Dependently Reduces Escalated Heroin Self-Administration in Rats

Do Orexins contribute to impulsivity-driven binge consumption of rewarding stimulus and transition to drug/food dependence?

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