The Differential Effect of the Presence of Adult Male and Female MICE on the Growth and Development of the Young

Fullerton, Clare; Cowley, J.J.

doi:10.1080/00221325.1971.10532630

Cited by 49 publications

(22 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…I have no solid explanation for this discrepancy, though strain differences, seasonal variations, variations in treatment duration or procedure, or other similar factors may contribute to the variation in reported results. Also, I note that Fullerton and Cowley (1971) found an acceleration of puberty when preweaning females were treated with urine from adult females, whereas in the present experiments 1 recorded delays in puberty when urine from females was applied to preweaning mice. This difference may be due to the fact that Fullerton and Cowley were using singly caged females for their urine collection and I have used grouped females in the present experiments.…”

Section: Discussioncontrasting

confidence: 70%

Preweaning stimulation with urinary chemosignals and age of puberty in female mice

Drickamer

1988

Developmental Psychobiology

View full text Add to dashboard Cite

Six experiments were conducted to assess the effects of preweaning stimulation with urinary chemosignals from four different sources on the age of sexual maturation in young female mice. The urinary chemosignals tested were those in male urine, urine from females in estrus, urine from pregnant or lactating females, and urine from females housed in groups. The split-litter technique was used for assigning mice to particular treatments. When treatments were applied during the period from 2 to 11 days postpartum, none of the chemosignals exerted any detectable influence on the age of first vaginal estrus. All 4 chemosignal treatments were effective in altering the age of puberty when treatment was applied daily from Days 12 to 21 postpartum. For urine from males and urine from estrous females, 3 days of treatment during the last 10 days prior to weaning at 21 days of age were sufficient to produce an acceleration of puberty. For urine from pregnant or lactating females, 5 days of treatment just prior to weaning were necessary to produce an acceleration of sexual development. For urine from grouped females, delays in puberty were produced only when the treatment lasted for 7 of the last 10 days prior to weaning. These findings suggest that the preweaning stimulus environment of young female mice may be important for their later sexual development. Further, use of the split-litter technique permitted the determination that variation in the age of puberty was smaller within than between litters; inheritance and/or maternal influences are clearly important factors affecting the age of sexual maturation.

show abstract

Section: Discussioncontrasting

confidence: 70%

Preweaning stimulation with urinary chemosignals and age of puberty in female mice

Drickamer

1988

Developmental Psychobiology

View full text Add to dashboard Cite

show abstract

“…Exposing infant female mice to the presence of adult female conspecifics slows the rate of sexual maturation (Vandenbergh, 1967(Vandenbergh, , 1969Fullerton and Cowley, 1971) and the substance(s) responsible for the delay are contained in the urine (Cowley and Wise, 1970 ;Drickamer, 1977 ; Colby and Vandenbergh, 1974). The picture is, however, complicated and a change in the composition of the urine, consequent upon a change in the reproductive state of the female, may have either a retarding or an accelerating effect on sexual development.…”

Section: Introductionmentioning

confidence: 99%

“…While sexual maturation and changes in the regularity of oestrous cycle have formed a focus of interest the effects of exposure on the behaviour of mice has received little attention. An increase in open field activity following exposure, in infancy, to adult male conspecifics contrasted with the effects of exposing infant mice to adult females (Fullerton and Cowley, 1971). ).…”

Section: Introductionmentioning

confidence: 99%

Post-parturition and late lactation urine : long-term effects of exposure on mouse activity and sniffing behaviour

Cowley¹,

Pewtress²

1986

Reprod. Nutr. Dévelop.

Self Cite

View full text Add to dashboard Cite

Summary. From the time of separation from their mothers infant mice were exposed for 10 consecutive days to urine from post-parturitional and late-lactational donor mice. They were then tested when adult on activity and sniffing behaviour.The sample of mice exposed to urine from late-lactational donors was associated with reduced activity when compared with mice exposed to post-parturitional urine and a water control sample. The long term effects of the urine on behaviour were also apparent in positional preferences in an open arena as judged by frequency of entry, and to a lesser extent, the time spent in the left and right hand segments. Mice exposed to late-lactational urine sniffed less than the other treatment samples though preferences for sniffing the urine that they had been exposed to in infancy were less marked. The urine did not accelerate puberty, but mice in the control sample had more vaginal dioestrous smears and fewer smears with a predominance of epithelial cells.Introduction.

show abstract

“…It has been shown, however, that exposure o f neonatal mice to the presence of adult mice can accelerate sexual development and that the pheromone is airborne (13,14). The exposure of infant female mice to adult male and female mice was also observed to exercise a different effect on their rate o f growth and Open Field behaviour (5). Further, the reproductive state of the donor may also differentially affect the rate of growth o f the young and the active substance(s) are contained in the urine (2).…”

Section: Discussionmentioning

confidence: 95%

The Effect of Litter Size on the Growth, Survival and Behaviour of Neonatal Bulbectomised Mice

Cooper¹,

Cowley²

1976

Neonatology

View full text Add to dashboard Cite

Bilateral lesions of the olfactory bulbs in 1-day-old mice led to a slow rate of growth both before and after weaning and the growth changes were positively associated with the size of the lesion. Mothers continued to care for the bulbectomised mice which showed no evidence of retarded motor development though their eyes opened later and they were less active when exposed to an artificial perfume. Bulbectomised mice failed to survive in litters of two where both infants were bulbectomised and in litters with a large number of unoperated littermates. Keeping litters small and having both bulbectomised and control mice present enhanced the chances of survival and the presence of infant control mice is a necessary condition for the maintenance of lactation and the survival of the bulbectomised babies. Failure to respond to the odours (pheromones) of the mothers may be responsible for the infrequent suckling and the slow growth and development.

show abstract

The Differential Effect of the Presence of Adult Male and Female MICE on the Growth and Development of the Young

Cited by 49 publications

References 17 publications

Preweaning stimulation with urinary chemosignals and age of puberty in female mice

Preweaning stimulation with urinary chemosignals and age of puberty in female mice

Post-parturition and late lactation urine : long-term effects of exposure on mouse activity and sniffing behaviour

The Effect of Litter Size on the Growth, Survival and Behaviour of Neonatal Bulbectomised Mice

Contact Info

Product

Resources

About