The differential ability of the phytoestrogen genistein and of estradiol to induce uterine weight and proliferation in the rat is associated with a substance specific modulation of uterine gene expression

Diel, Patrick; Geis, Renate-B.; Caldarelli, Antonio; Schmidt, Simone; Leschowsky, Ute Laudenbach; Voss, Anika; Vollmer, Günter

doi:10.1016/j.mce.2004.04.006

Cited by 78 publications

(86 citation statements)

References 45 publications

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“…These include determination of uterine epithelial cell height, uterine gland formation, cell proliferation, rat uterine gene expression e.g. complement C3, progesterone receptor, clusterin, and the production of the estrogen-inducible protein, lactoferrin in the uterine epithelial cells (Ashby, 2001;Diel et al, 2001;Newbold et al, 2001;Jefferson et al, 2002;Diel et al, 2004).…”

Section: Testing Estrogenicity Testing Estrogenicity Testing Estrogenmentioning

confidence: 99%

Tools to evaluate estrogenic potency of dietary phytoestrogens:A consensus paper from the EU Thematic Network “Phytohealth” (QLKI-2002-2453)

Saarinen

Bingham²,

Lorenzetti

et al. 2006

Genes Nutr

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Section: Testing Estrogenicity Testing Estrogenicity Testing Estrogenmentioning

confidence: 99%

Tools to evaluate estrogenic potency of dietary phytoestrogens:A consensus paper from the EU Thematic Network “Phytohealth” (QLKI-2002-2453)

Saarinen

Bingham²,

Lorenzetti

et al. 2006

Genes Nutr

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“…The accumulation of intra-abdominal fat has emerged as a risk factor for metabolic syndrome which increases the risk of diabetes, dyslipidemia, hypertension and cardiovascular disease (Björntorp 1996;Tchernof and Després 2013). However, genistein administration increases uterine mass, although not as much as estrogen therapy (Diel et al 2004). Treatment with resveratrol has only a weak estrogenic effect and induces proliferation of uterine cells, but it suppresses the metabolic alteration in OVX rats (Majumdar et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Cyanidin and malvidin in aqueous extracts of black carrots fermented with Aspergillus oryzae prevent the impairment of energy, lipid and glucose metabolism in estrogen-deficient rats by AMPK activation

Park

Kang²,

Jeong³

et al. 2015

Genes Nutr

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Black carrots (Daucus carota L.) are rich in anthocyanins which contribute many health benefits, but are limited by bioavailability and instability when exposed to oxygen, heat and light. Fermenting black carrots may improve the stability, absorption and bioactivity of its anthocyanins. Here, we examined whether and by what mechanisms the long-term consumption of unfermented black carrot extract (BC) and its extracts fermented with Lactobacillus plantarum (BCLP) or Aspergillus oryzae (BCAO) might prevent menopausal symptoms including impaired energy, glucose and lipid metabolism in estrogen-deficient animals with diet-induced obesity. Ovariectomized (OVX) rats were fed four different high-fat diets containing 2 % dextrin (OVX-control), 2 % BC, 2 % BCLP, or 2 % BCAO for 12 weeks. Sham rats were fed high-fat diets containing 2 % dextrin. The contents of total anthocyanins increased in BCAO compared to BC and BCLP, whereas the contents of cyanidin-3-rutinosides, malvidin-3,5-diglycosides and delphine-3-glucoside were lower and cyanidin and malvidin were much higher in BCLP and BCAO than BC. Fat mass and weight gain were lower in descending order of OVX-control [ BC and BCLP [ BCAO due to increased energy expenditure and fat oxidation. However, BC, BCLP and especially BCAO all normalized HOMA-IR, an indicator of insulin resistance and glucose intolerance, in OVX rats. OVX increased serum total and LDL cholesterol and triglycerides, but BC, BCLP and BCAO significantly prevented the increases. BCAO markedly decreased hepatic triglyceride levels by increasing gene expressions of CPT-1 and PPAR-a, which are involved in fatty acid oxidation, and decreasing mRNA expressions of FAS and SREBP-1c, which are associated with fatty acid synthesis. This was related to increased pAMPK ? pACC signaling and improved hepatic insulin signaling (pAkt ? pFOXO-1). Cyanidin and malvidin markedly decreased fat accumulation in 3T3-L1 adipocytes by increasing CPT-1 and decreasing FAS and SREBP-1c expression in comparison with cyanidin-3-rutinoside and malvidin-3,5-diglycosides. In conclusion, with increasing cyanidin and malvidin, BCAO prevented the exacerbation of lipid and glucose metabolism by activating hepatic insulin signaling and AMPK activation by in OVX rats.

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“…52: [537][538][539][540][541][542] 2006) t has been recognized that the roots of Pueraria mirifica (PM), a Thai herbal plant, contain many kinds of phytoestrogens, such as genistein, daidzein, and coumestrol, which are also found in soy plants and soy products, and miroestrol, deoxymiroestrol, peurarin, and mirificin [1][2][3][4]. The phytoestrogens from soys [5,6] and PM roots [7][8][9] have been reported to have estrogenic actions in both in vivo and in vitro studies. The estrogenic effect of PM was examined in vitro using MCF-7 cell proliferation and HepG2 cell transient transfection assay [7,8].…”

mentioning

confidence: 99%

“…The phytoestrogens from soys [5,6] and PM roots [7][8][9] have been reported to have estrogenic actions in both in vivo and in vitro studies. The estrogenic effect of PM was examined in vitro using MCF-7 cell proliferation and HepG2 cell transient transfection assay [7,8].…”

mentioning

confidence: 99%

Effect of Pueraria mirifica on the Sexual Skin Coloration of Aged Menopausal Cynomolgus Monkeys

Trisomboon

Malaivijitnond

Cherdshewasart

et al. 2006

Journal of Reproduction and Development

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Abstract. To investigate the estrogenic effect of Pueraria mirifica (PM), a Thai herbal plant that contains many phytoestrogens, sexual skin coloration was studied in cynomolgus monkeys. Aged menopausal monkeys were divided into three groups. Each group (n=3) was fed 10, 100, or 1,000 mg of PM daily. The treatment schedule was divided into three periods, a 30-day pre-treatment period, 90-day treatment period, and 60-day post-treatment period. The results show that the sexual skin exhibited reddish coloration within 24 h after PM-treatment and remained this way for the first half of the PMfeeding period. The changes in sexual skin coloration were not dose-dependent. The present results indicate that PM had estrogenic action by increasing reddish sexual skin coloration in aged menopausal monkeys. Key words: Macaca fascicularis, Phytoestrogens, Pueraria mirifica, Sexual skin (J. Reprod. Dev. 52: [537][538][539][540][541][542] 2006) t has been recognized that the roots of Pueraria mirifica (PM), a Thai herbal plant, contain many kinds of phytoestrogens, such as genistein, daidzein, and coumestrol, which are also found in soy plants and soy products, and miroestrol, deoxymiroestrol, peurarin, and mirificin [1][2][3][4]. The phytoestrogens from soys [5,6] and PM roots [7][8][9] have been reported to have estrogenic actions in both in vivo and in vitro studies. The estrogenic effect of PM was examined in vitro using MCF-7 cell proliferation and HepG2 cell transient transfection assay [7,8]. PM had a dual effect on the growth of MCF-7 human mammary adenocarcinoma cells after 4 days of incubation, i.e. stimulating growth at a low dose and suppressing it with a high dose [8]. PM also showed estrogenic activity on a human hepatoma cell line, HepG2 cells, containing estrogen receptor and luciferase reporter gene [7]. Administration of PM produced cornified cells, g r o w t h o f t h e e n d o m e t r i u m g l a n d , a n d proliferation of spiral arteries in ovariectomized rats [9]. Furthermore, we reported in a recent investigation that daily feeding of PM had an estrogenic effect by suppressing gonadotropin and estrogen secretions in aged female cynomolgus monkeys [10].The influence of estrogen on the sexual skin area around the perineum to the base of the tail has been

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The differential ability of the phytoestrogen genistein and of estradiol to induce uterine weight and proliferation in the rat is associated with a substance specific modulation of uterine gene expression

Cited by 78 publications

References 45 publications

Tools to evaluate estrogenic potency of dietary phytoestrogens:A consensus paper from the EU Thematic Network “Phytohealth” (QLKI-2002-2453)

Tools to evaluate estrogenic potency of dietary phytoestrogens:A consensus paper from the EU Thematic Network “Phytohealth” (QLKI-2002-2453)

Cyanidin and malvidin in aqueous extracts of black carrots fermented with Aspergillus oryzae prevent the impairment of energy, lipid and glucose metabolism in estrogen-deficient rats by AMPK activation

Effect of Pueraria mirifica on the Sexual Skin Coloration of Aged Menopausal Cynomolgus Monkeys

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