The Different Strategies for the Radiolabeling of [211At]-Astatinated Radiopharmaceuticals
Jie Gao,
Mei Li,
Jingjing Yin
et al.
Abstract:Astatine-211 (211At) has emerged as a promising radionuclide for targeted alpha therapy of cancer by virtue of its favorable nuclear properties. However, the limited in vivo stability of 211At-labeled radiopharmaceuticals remains a major challenge. This review provides a comprehensive overview of the current strategies for 211At radiolabeling, including nucleophilic and electrophilic substitution reactions, as well as the recent advances in the development of novel bifunctional coupling agents and labeling app… Show more
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