The Different Impact of VEGF-A and VEGF-D on Peritumoral Brain Edema

Abstract

The study consisted of VEGF-A and VEGF-D levels analysis in the blood samples in patients with brain tumors. VEGF is a family of angiogenic factors. This study evaluated the association between VEGF-A and VEGF-D levels and the extent of peritumoral brain edema. The study group was divided into patients with moderate and severe edema based on the Stenih off scale and its modification for posterior foss a tumors. It was found that plasma VEGF-A level in patients with severe brain edema was significantly higher (Me = 25.42 pg/ml) than in patients with moderate brain edema (Me = 29.18 pg / ml) -U Mann-Whitney test, p = 0.0258. It was also found that VEGF-D plasma level in patients with severe brain edema was significantly lower (Me = 95.25 pg / ml) than in patients with moderate brain edema (Me = 183.57 pg / ml) -Mann-Whitney test, p = 0.0034. It was also found that the plasma concentration of VEGF-D in patients with better functional status was significantly higher (Me = 185.47pg / ml) than the concentration in patients with worse functional status (Me = 111.34pg / ml) -U Mann-Whitney test, p = 0.0428. The above results proved that VEGF-A and VEGF-D present omni directional association with peritumoral brain edema in patients with intracranial tumors. VEGF-A promotes the formation of peritumoral edema, while the relationship between VEGF-D and brain edema seems to be the opposite of VEGF-A.