The different faces of Creutzfeldt-Jacob Disease CJD in psychiatry

Abudy, Anat; Juven‐Wetzler, Alzbeta; Zohar, Joseph

doi:10.1016/j.genhosppsych.2014.02.002

Cited by 15 publications

(10 citation statements)

References 11 publications

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“…They later get worsened despite standard psychiatric treatments. [4][5][6] As seen in our case, the accompanying cognitive deficits become obscured by prominent behavior and personality changes due to which a primary psychiatric disorder may be suspected. 7 Usually, there is a rapid neuropsychiatric deterioration and death occurs within a year of symptom onset.…”

Section: Discussionsupporting

confidence: 52%

“…However, psychiatric manifestations, including depression, psychosis, and sleep disturbances, maybe the only manifestations of sCJD and thus are misdiagnosed. They later get worsened despite standard psychiatric treatments . As seen in our case, the accompanying cognitive deficits become obscured by prominent behavior and personality changes due to which a primary psychiatric disorder may be suspected …”

Section: Discussionmentioning

confidence: 55%

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The first reported case of Creutzfeldt‐Jakob disease from Nepal

Kharel

Adhikari

Pokhrel

et al. 2019

Clinical Case Reports

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 55%

The first reported case of Creutzfeldt‐Jakob disease from Nepal

Kharel

Adhikari

Pokhrel

et al. 2019

Clinical Case Reports

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“…Even though neuropsychiatric symptoms constitute an early and prominent manifestation of CJD, clinicians typically ignore these symptoms in its diagnostic approach (Abudy et al, 2014). The presence of late-onset unspecific visual symptoms in conjunction with affective or psychotic symptoms should include CJD in the differential diagnosis (Abudy et al, 2014). Repeated EEG and imaging examinations may be performed at different time points, as they might be normal initially (Abudy et al, 2014).…”

Section: To the Editormentioning

confidence: 99%

“…The presence of late-onset unspecific visual symptoms in conjunction with affective or psychotic symptoms should include CJD in the differential diagnosis (Abudy et al, 2014). Repeated EEG and imaging examinations may be performed at different time points, as they might be normal initially (Abudy et al, 2014). This report provides further evidence on the importance of psychiatric symptoms in the assessment of CJD.…”

mentioning

confidence: 99%

Neuropsychiatric symptoms in the Heidenhain variant of Creutzfeldt–Jakob’s disease mistaken for major depression and functional neurological disorder

Restrepo-Martínez

Chacón-González

Oñate‐Cadena

et al. 2019

Aust N Z J Psychiatry

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“…Expediating a sCJD diagnosis is of great significance. Almost half of patients were misdiagnosed first as “psychiatric patients” (57). Consequently, it is very important for psychiatrists to consider CJD among the possible differential diagnoses in elderly patients.…”

Section: Discussionmentioning

confidence: 99%

Does the Use of Antidepressants Accelerate the Disease Progress in Creutzfeldt–Jakob Disease Patients With Depression? A Case Report and A Systematic Review

et al. 2019

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Background: Creutzfeldt–Jakob disease (CJD) is a fatal neurodegenerative disorder characterized by rapidly progressive dementia. Growing evidence suggests that antidepressant usage was associated with dementia. Given the commonality of depression in CJD, it is necessary to investigate the effect of antidepressants on CJD. Methods: First, we report a case of sporadic CJD (sCJD) with depression where the condition worsened rapidly after using a serotonin and noradrenaline reuptake inhibitor (SNRI) antidepressant. Second, a systematic literature survey was conducted to investigate the effect of antidepressants on the survival time of sCJD patients with depression. Thirteen cases plus our case were included for qualitative analysis. Twelve subjects were included in the Kaplan–Meier survival and Cox regression analysis. Finally, we provide a postulation of pathophysiological mechanism in CJD. Results: The median survival time of all patients was 6.0 months, of which patients with SNRIs were significantly shorter than those with first-generation antidepressants (2.0 vs. 6.0 months; log rank, P = .008) and relatively shorter than those with nonselective serotonin reuptake inhibitors (SSRIs; 4.0 vs. 6.0 months; log rank, P = .090). In comparison with first-generation antidepressants, the use of SNRIs [hazard ratio (HR), 23.028; 95% confidence interval (CI), 1.401 to 378.461; P = .028] remained independently associated with shorter survival time. Conclusions: The use of antidepressants, especially SNRIs, was associated with a shorter survival time of sCJD patients. The possible changes in neurotransmitters should be emphasized. Scientifically, this study may provide insights into the mechanism of CJD. Clinically, it may contribute to the early diagnosis of CJD.

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The different faces of Creutzfeldt-Jacob Disease CJD in psychiatry

Cited by 15 publications

References 11 publications

The first reported case of Creutzfeldt‐Jakob disease from Nepal

The first reported case of Creutzfeldt‐Jakob disease from Nepal

Neuropsychiatric symptoms in the Heidenhain variant of Creutzfeldt–Jakob’s disease mistaken for major depression and functional neurological disorder

Does the Use of Antidepressants Accelerate the Disease Progress in Creutzfeldt–Jakob Disease Patients With Depression? A Case Report and A Systematic Review

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