The different expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and possible roles in gastric carcinomas

Zhou, Chengjun; Liu, Bin; Zhu, Kongxi; Zhang, Tingguo; Xu, Weihua; Wang, Hongbo; Yu, Weihua; Qu, Yundong; Wang, Hongjuan; Wu, Hong-Li; Sun, Song; Guo, Jianqiang

doi:10.1016/j.prp.2009.01.006

Cited by 33 publications

(22 citation statements)

References 17 publications

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“…Similar changes on cEAcAM1 cellular distribution were also observed by Zhou et al [63] in gastric carcinoma. The authors analyzed cEAcAM1 expression in paraffin wax sections of 222 patients with gastric adenocarcinomas classified into three histo-ceAcAm1 And cAncer orIgInAl ArtIcles And reVIews types following the Laurén classification: intestinal, diffuse, and mixed carcinomas.…”

Section: Expression and Association Of Inhibitor Of Differentiation (supporting

confidence: 86%

The expression and modulation of CEACAM1 and tumor cell transformation

Fiori¹,

Magnani

Cianfriglia

2012

Annali Dell'Istituto Superiore Di Sanità

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Abstract.Background. In this review, we focus our discussion on one class of carcinoembryonic antigen-related cell adhesion molecules, carcinoembryonic antigen-related cell adhesion molecules 1 (cEAcAM1). This has been observed in several malignant transformations to be subjected to complex mechanisms of modulation and dysregulation. aims. Restoration of cEAcAM1 expression in tumor cell lines often abolishes their oncogenicity in vivo, and therefore, this adhesion molecule has been regarded as a tumor suppressor. In contrast, de novo expression of cEAcAM1 is found with the progression of malignancy and metastatic spread in a large array of cancer tissues which include melanoma, Non Small cell Lung carcinoma (NScLc) as well as bladder, prostate, thyroid, breast, colon and gastric carcinomas. Discussion.We report and discuss the most significant findings confirming at immunohistochemical and clinical level the correlation between poor prognosis and expression of cEAcAM1 on the cell surface of tumors.Key words: cEAcAM1, cancer, dysregulation, NScLc, melanoma, poor prognosis. Riassunto (Espressione e modulazione cellulare di CEaCaM1 e trasformazione tumorale).In questo articolo abbiamo focalizzato il nostro interesse su di una classe di molecole di adesione e più in particolare sul cEAcAM1 che in diversi studi è stato osservato essere coinvolto nella trasformazione tumorale attraverso complessi meccanismi di modulazione e di alterata regolazione. Obiettivo. L'espressione di cEAcAM1 risulta spesso associata con l'abolizione della oncogenicità di linee cellulari trasformate e pertanto questa molecola di adesione è stata considerata alla stregua di un immunosoppressore tumorale. Discussione. In contrasto con questa osservazione, in molti casi l'espressione de novo di cEAcAM1 risulta essere associata con la progressione tumorale e la metastatizzazione di diverse forme di cancro che includono il melanoma, il carcinoma polmonare a non piccole cellule, il carcinoma della vescica, della prostata, mammario, tiroideo e del carcinoma gastrico e del colon. In questo articolo riportiamo i dati più significativi della letteratura corrente che dimostrano attraverso studi immunoistochimici e clinici una stretta correlazione fra prognosi infauste ed espressione del cEAcAM1 sulla superficie di cellule tumorali.Parole chiave: cEAcAM1, cancro, alterata regolazione, NScLc, melanoma, prognosi infausta.

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Section: Expression and Association Of Inhibitor Of Differentiation (supporting

confidence: 86%

The expression and modulation of CEACAM1 and tumor cell transformation

Fiori¹,

Magnani

Cianfriglia

2012

Annali Dell'Istituto Superiore Di Sanità

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“…34 We think that different expression patterns and impact on angiogenesis may play crucial roles in gastric carcinogenesis and progression. In this study, we found that CEACAM1 has different expression patterns in nonneoplastic and neoplastic lesions and has different impacts on angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Different Expression Patterns of CEACAM1 and its Impacts on Angiogenesis in Gastric Nonneoplastic and Neoplastic Lesions

Guo

Wang

et al. 2011

Ann Surg Oncol

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“…All the 21 NSCLC were categorized into a high expression group (i.e., ≥ 66% positive tumour cells) and a low expression group (i.e., < 66% positive tumour cells) according to the percentage of positive tumour cells [23,29,30] (Figure 1). The high or low classifications were independently assigned by two experienced pathologists and consensus was achieved after discussion.…”

Section: Methodsmentioning

confidence: 99%

Clinical and experimental studies regarding the expression and diagnostic value of carcinoembryonic antigen-related cell adhesion molecule 1 in non-small-cell lung cancer

Zhou

Liu

et al. 2013

BMC Cancer

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BackgroundCarcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a multifunctional Ig-like cell adhesion molecule that has a wide range of biological functions. According to previous reports, serum CEACAM1 is dysregulated in different malignant tumours and associated with tumour progression. However, the serum CEACAM1 expression in non-small-cell lung carcinomas (NSCLC) is unclear. The different expression ratio of CEACAM1-S and CEACAM1-L isoform has seldom been investigated in NSCLC. This research is intended to study the serum CEACAM1 and the ratio of CEACAM1-S/L isoforms in NSCLC.MethodsThe expression of the serum CEACAM1 was determined by enzyme-linked immunosorbent assay. The protein expression and the location of CEACAM1 in tumours were observed by immunohistochemical staining. The CEACAM1 mRNA levels in tumour and normal adjacent tissues were measured using quantitative real-time PCR, and the expression patterns and the rate of CEACAM1-S and CEACAM1-L were analysed by reverse transcription-PCR.ResultsSerum CEACAM1 levels were significantly higher in NSCLC patients compared with that from normal healthy controls (P <0.0001). 17 patients (81%) among 21 showed high expression of CEACAM1 by immunohistochemical staining. Although no significant differences were found between tumour and normal tissues on mRNA expression levels of CEACAM1 (P >0.05), the CEACAM1-S and the CEACAM1-S/L (S: L) ratios were significantly higher in tumour than normal tissues (P <0.05).ConclusionsOur data indicated that the serum levels of CEACAM1 could discriminate lung cancer patients from health donors and that CEACAM1 might be a useful marker in early diagnosis of NSCLC. Moreover, our results showed that the expression patterns of CEACAM1 isoforms could be changed during oncogenesis, even when total CEACAM1 in tumour tissues did not show significant changes. Our study suggested that the expression ratios of CEACAM1-S/CEACAM1-L might be a better diagnostic indicator in NSCLC than the quantitative changes of CEACAM1.

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The different expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and possible roles in gastric carcinomas

Cited by 33 publications

References 17 publications

The expression and modulation of CEACAM1 and tumor cell transformation

The expression and modulation of CEACAM1 and tumor cell transformation

Different Expression Patterns of CEACAM1 and its Impacts on Angiogenesis in Gastric Nonneoplastic and Neoplastic Lesions

Clinical and experimental studies regarding the expression and diagnostic value of carcinoembryonic antigen-related cell adhesion molecule 1 in non-small-cell lung cancer

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