The differences of clinicopathological factors for breast cancer in respect to time of recurrence and effect on recurrence-free survival

Ustaalioğlu, Bala Basak Oven; Balvan, Ozlem; Bılıcı, Ahmet; Develi, A.; Aliustaoğlu, Mehmet; Vardar, Fugen Aker; Erkol, Burçak

doi:10.1007/s12094-015-1323-x

Cited by 11 publications

(6 citation statements)

References 22 publications

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“…Despite this increase in survival, women diagnosed with BC, and treated with surgery plus adjuvant therapy have a recurrence risk of 5%–13% [ 4 , 5 ]. Tumor size and axillary lymph node metastasis are the most relevant risk factors for tumor relapse [ 6 , 7 ]. The primary means for reducing recurrence is medical intervention (e.g., chemotherapy, radiation, and endocrine treatment) [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Beliefs and Behaviors about Breast Cancer Recurrence Risk Reduction among African American Breast Cancer Survivors

Ansa

Yoo

Whitehead³

et al. 2015

IJERPH

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A growing body of evidence suggests that breast cancer recurrence risk is linked to lifestyle behaviors. This study examined correlations between breast cancer recurrence, risk reduction beliefs, and related behaviors among African American breast cancer survivors (AA BCSs). Study participants included 191 AA BCSs, mean age = 56.3 years, who completed a lifestyle assessment tool. Most respondents believed that being overweight (52.7%), lack of physical activity (48.7%), and a high fat diet (63.2%) are associated with breast cancer recurrence. Over 65% considered themselves overweight; one third (33.5%) agreed that losing weight could prevent recurrence, 33.0% disagreed, while the remaining 33.5% did not know; and nearly half (47.9%) believed that recurrence could be prevented by increasing physical activity. Almost 90% survivors with BMI < 25 Kg/M2 reported no recurrence compared to 75.7% with BMI ≥ 25 Kg/M2 (p = 0.06); nearly all of the women (99.2%) answered “yes” to seeking professional help to lose weight, 79.7% of which were recurrence-free (p = 0.05). These results provide information about AA BCSs’ beliefs and behaviors protective against breast cancer recurrence. Additional research is warranted to determine the effectiveness of educational interventions for AA BCSs that promote consumption of a healthy diet and engaging in regular physical activity.

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Section: Introductionmentioning

confidence: 99%

Beliefs and Behaviors about Breast Cancer Recurrence Risk Reduction among African American Breast Cancer Survivors

Ansa

Yoo

Whitehead³

et al. 2015

IJERPH

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“…With respect to the relationship between the degree of tumor malignancy and TTR, Fujii et al [21] showed that a lower pathological T stage was significantly more common in the late-recurrence group (after 5 years from resection) than in the early-recurrence group (within 5 years from resection) in patients with renal cell carcinoma. Oven et al [22] also showed a similar tendency in breast cancer patients. Consistent with these previous studies, our study showed that tumors with low mitotic count were significantly more common in the L-group.…”

Section: Discussionmentioning

confidence: 66%

Appropriate Follow-Up Strategies for Gastrointestinal Stromal Tumor Patients Based on the Analysis of Recurrent Interval and Patterns

et al. 2017

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Background/Aims: Previous studies have proposed risk classifications for patients with gastrointestinal stromal tumor (GIST) after resection and have contributed to the prediction of its prognosis. However, optimal postoperative surveillance has not yet been established. Methods: We retrospectively analyzed data from 115 GIST patients who experienced recurrence after complete resection. The relationships between clinicopathological characteristics and the first recurrence sites, or time to recurrence (TTR), were investigated. We also compared the characteristics between 2 subgroups based on a TTR of ≤5 or >5 years. Results: The first recurrence occurred in the abdomen in 114 of 115 patients (99.1%); one case of esophageal GIST recurred in the lung. Gastric and small intestinal GISTs recurred most frequently in the liver or peritoneum, while the most common recurrences of colorectal GISTs were found to be local. Fourteen patients (12.2%) experienced recurrence after >5 years. Smaller tumors and those categorized as lower risk were significantly more frequent in the TTR >5 years group than in the TTR ≤5 years group. In the TTR >5 years group, local recurrence was the most frequent type of recurrence (42.9%). Conclusion: Based on abdominal examination, postoperative surveillance after complete resection for primary GISTs may be recommended for >5 years.

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“…Disease extent in patients with metastatic breast cancer is highly variable, ranging from solitary bone metastasis to widespread bone marrow involvement, and often including extra-skeletal sides such as lung, pleura, liver and lymph nodes [ 18 ]. Thus, survival of these patients might vary from few months to several years.…”

Section: Discussionmentioning

confidence: 99%

Contemporary radiooncological management of bone metastases from breast cancer: factors associated with prescription of different fractionation regimens (short or long course) in a rural part of North Norway with long travel distance

Nieder

Dalhaug

Haukland

et al. 2017

International Journal of Circumpolar Health

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The aim of this study was to reduce barriers that prevent implementation of evidence-based recommendations about single-fraction palliative radiotherapy (PRT) and to demonstrate that single-fraction PRT yields similar outcomes as long-course treatment (≥10 fractions) in patients with bone metastases from breast cancer. This retrospective study (2007–2014) included 118 Norwegian female patients. All patients received guideline-conform systemic therapy including bone-targeting agents. Median survival was 12.7 months. Long-course PRT was prescribed in 60% of patients, while 21% had PRT with a single fraction of 8 Gy to at least one target. Reirradiation rate was not significantly higher after 8 Gy (9%, compared to 5% after long-course PRT and 6% after 4 Gy x5). Patients with favorable baseline characteristics such as younger age and good performance status (PS) were significantly more likely to receive long-course PRT. Biological subtype and comorbidity did not correlate with fractionation. Prognosis was influenced by biological subtype, extra-skeletal disease extent, severe anemia and abnormal CRP. The limited need for reirradiation after single fraction PRT might encourage physicians to prescribe this convenient regimen, which would improve resource utilization. Even patients with PS3 had a median survival of 3 months, which indicates that they could experience worthwhile clinical benefit.

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The differences of clinicopathological factors for breast cancer in respect to time of recurrence and effect on recurrence-free survival

Abstract: Clinicopathological factors predicting the recurrence time in breast cancer were important to modify adjuvant therapy.

Cited by 11 publications

References 22 publications

Beliefs and Behaviors about Breast Cancer Recurrence Risk Reduction among African American Breast Cancer Survivors

Beliefs and Behaviors about Breast Cancer Recurrence Risk Reduction among African American Breast Cancer Survivors

Appropriate Follow-Up Strategies for Gastrointestinal Stromal Tumor Patients Based on the Analysis of Recurrent Interval and Patterns

Contemporary radiooncological management of bone metastases from breast cancer: factors associated with prescription of different fractionation regimens (short or long course) in a rural part of North Norway with long travel distance

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