The Difference of Cholesterol, Platelet and Cortisol Levels in Patients Diagnosed with Chronic Heart Failure with Reduced Ejection Fraction Groups According to Neutrophil Count

Mongirdienė, Aušra; Laukaitienė, Jolanta; Skipskis, Vilius; Kuršvietienė, Lolita; Liobikas, Julius

doi:10.3390/medicina57060557

Cited by 6 publications

(8 citation statements)

References 28 publications

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“…Several studies have confirmed the safety and effectiveness of remote monitoring of the 24-hour average heart rate and other parameters [ 26 , 27 ]. Some scholars have pointed out that the increase of the 24-hour average heart rate, heart rate variability, and the decrease of patient activity could reflect the clinical status of patients and predict heart failure decompensation events [ 28 ]. The results of other scholars showed that the admission rate of the remote monitoring group was significantly lower than that of the routine follow-up group and the annual admission rate of heart failure per patient in the remote monitoring group decreased from 0.526 to 0.272 [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of ICD/CRT-D Implantation on Adverse Events and Readmission Rate in Patients with Chronic Heart Failure (CHF)

Liu

Xing

2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the effect of implantable cardioverter defibrillator/cardiac resynchronization therapy defibrillator (ICD/CRT-D) implantation on adverse events and the readmission rate in patients with chronic heart failure (CHF). Methods. Sixty patients with CHF treated in our hospital from April 2019 to July 2021 were enrolled. The patients were randomly assigned into the control group and study group. The control group received routine intervention, and the study group received remote management with ICD/CRT-D implantation. Results. First of all, we compared the general data of the two groups. There was no significant difference in LVEF, NYHA grade, concomitant disease, and history of arrhythmia ( P > 0.05 ). Secondly, we compared the end-point events. In the study group, 5 cases of heart failure were readmitted, 0 cases died, and 4 cases were admitted to hospital with arrhythmia and ICD events, with a total incidence of 30.0%, while in the control group, 12 cases were rehospitalized with heart failure, 3 cases died, 25 cases were admitted with arrhythmia and ICD events, and the total incidence rate was 56.67% ( P < 0.05 ). In terms of the readmission rate of patients with heart failure in grade NYHAII and grade III, among the patients with grade NYHAII, the number of patients with heart failure less than once in the study group was higher compared to that in the control group and the number of patients with heart failure ≥ once in the study group was lower compared to that in the control group ( P < 0.05 ). Among the patients with grade NYHAIII, the number of patients with heart failure less than once in the study group was higher compared to that in the control group and the number of patients with heart failure ≥ once in the study group was lower compared to that in the control group. There exhibited no significant difference in the data ( P > 0.05 ). Considering the occurrence of VT and VF events, the study team reported that 14 patients recorded a total of 276 ventricular arrhythmias: 261 ventricular tachycardia and 15 ventricular fibrillations. Among them, 24 VT (9.2%) and 4 VF (26.7%) were determined to be misrecognition of the equipment. A total of 178 ventricular arrhythmias were recorded in 13 patients in the control group, including 152 ventricular tachycardia and 26 ventricular fibrillations. Among them, 10 VT (6.6%) and 8 VF (30.8%) were determined as misrecognition of the device. In regard to the treatment results of the two groups, after admission to the hospital for radio frequency, ablation, and adjustment of drug treatment to reprogram control, the patients did not reappear to have CRT-D misidentification and misdischarged. Finally, we compared the diagnosis time of VT/VE events. The time from VT/VE events to diagnosis in 14 patients in the study group was 2.55 ± 1.41 days, and that in 13 patients in the control group was 37.32 ± 15.31 days. The discovery of ICD events in the study group was significantly earlier compared to that in the routine follow-up group ( P < 0.05 ). This gives doctors enough time to assess the patient’s condition and determine a further diagnosis and treatment plan. Conclusion. Using ICD/CRT-D implantation to remotely monitor patients with CHF, through remote monitoring of the 24-hour average heart rate and the heart rate at rest and patient activity and other parameters and early intervention, the readmission rate caused by the deterioration of heart failure can be reduced. Compared with routine follow-up, remote monitoring significantly reduced the diagnosis time of VT/VE events.

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Section: Discussionmentioning

confidence: 99%

Effect of ICD/CRT-D Implantation on Adverse Events and Readmission Rate in Patients with Chronic Heart Failure (CHF)

Liu

Xing

2022

Computational and Mathematical Methods in Medicine

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“…It has also been shown that in HFrEF patients, separated into two groups according to neutrophil count (relatively low and high), the CRP and fibrinogen concentrations and monocyte count were higher in the group with a higher neutrophil count [97,99]. These observations are in line with low inflammatory environment in HFrEF patients.…”

Section: Influence Of Monocyte Secreted Cytokines and Inflammatory Readings On Hfref And Hfpef Developmentmentioning

confidence: 73%

“…The deceased persons were of older age, were characterized by worse NYHA functional class, and contained a higher NT-proBNP level [85]. Moreover, the NYHA functional class correlated with total monocyte count and percentage, and the CRP concentration correlated with NT-proBNP level in HFrEF as well [98,99]. Therefore, it could be assumed that the more affected heart muscle is, the higher pro-inflammatory environment is related to the predominance of Mon2 subset in patients with CHF (see Table 3).…”

Section: The Distribution Of Monocytes In Chfmentioning

confidence: 98%

Phenotypic and Functional Heterogeneity of Monocyte Subsets in Chronic Heart Failure Patients

Mongirdienė¹,

Liobikas²

2021

Preprint

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Chronic heart failure (CHF) results when heart cannot constantly supply the body tissues with oxygen and required nutrients, and it can be categorized as heart failure (HF) with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). There are different causes and mechanisms of the HF pathogenesis; however, the inflammation can be regarded as one of the factors promoting both HFrEF and HFpEF. Monocytes, a subgroup of leucocytes, are known as cellular mediators in response to cardiovascular injury and are closely related to inflammatory reactions. These cells are a vital component of the immune system and are the source of macrophages, which participate in cardiac tissue repair after injury. However, the monocytes are not homogenous as thought, and thus can present different functions under different cardiovascular disease conditions. In addition, there is still an open question whether the functions of monocytes and macrophages should be regarded as a cause or a consequence in CHF development. Therefore, our aim was to summarize the current studies on the function of various monocyte subsets in CHF with a focus on the role of a certain monocyte subset in HFpEF and HFrEF patients, and the relation to inflammatory markers.

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“…Older deceased patients were characterized by a worse NYHA functional class and contained a higher amino-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP) level [ 73 ]. Moreover, the NYHA functional class correlated with the total monocyte count and percentage, and the CRP concentration correlated with the NT-proBNP level in HFrEF [ 80 , 81 ]. Therefore, it can be presumed that the more affected the heart muscle is, the more strongly the pro-inflammatory environment is related to the predominance of the Mon2 subset in patients with CHF (see Table 2 ).…”

Section: Monocytes In Chfmentioning

confidence: 99%

“…It was also shown that among HFrEF patients separated into two groups according to neutrophil count (relatively low and high), the CRP and fibrinogen concentrations and monocyte count were higher in the group with a higher neutrophil count [ 6 , 81 ]. These observations are in line with the low inflammatory environment observed in HFrEF patients.…”

Section: Monocytes In Chfmentioning

confidence: 99%

Phenotypic and Functional Heterogeneity of Monocyte Subsets in Chronic Heart Failure Patients

Mongirdienė

Liobikas

2022

Biology

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Chronic heart failure (CHF) results when the heart cannot consistently supply the body’s tissues with oxygen and required nutrients. CHF can be categorized as heart failure (HF) with preserved ejection fraction (HFpEF) or HF with reduced ejection fraction (HFrEF). There are different causes and mechanisms underlying HF pathogenesis; however, inflammation can be regarded as one of the factors that promotes both HFrEF and HFpEF. Monocytes, a subgroup of leukocytes, are known to be cellular mediators in response to cardiovascular injury and are closely related to inflammatory reactions. These cells are a vital component of the immune system and are the source of macrophages, which participate in cardiac tissue repair after injury. However, these monocytes are not as homogenous as thought and can present different functions under different cardiovascular disease conditions. In addition, there is still an open question regarding whether the functions of monocytes and macrophages should be regarded as causes or consequences in CHF development. Therefore, the aim of this work was to summarize current studies on the functions of various monocyte subsets in CHF with a focus on the role of a certain monocyte subset in HFpEF and HFrEF patients, as well as the subsets’ relationship to inflammatory markers.

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The Difference of Cholesterol, Platelet and Cortisol Levels in Patients Diagnosed with Chronic Heart Failure with Reduced Ejection Fraction Groups According to Neutrophil Count

Cited by 6 publications

References 28 publications

Effect of ICD/CRT-D Implantation on Adverse Events and Readmission Rate in Patients with Chronic Heart Failure (CHF)

Effect of ICD/CRT-D Implantation on Adverse Events and Readmission Rate in Patients with Chronic Heart Failure (CHF)

Phenotypic and Functional Heterogeneity of Monocyte Subsets in Chronic Heart Failure Patients

Phenotypic and Functional Heterogeneity of Monocyte Subsets in Chronic Heart Failure Patients

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