The Difference of Brainstem Auditory Evoked Potential Latency in Diabetic Patient with Good and Poor Glycemic Control

Samatra, Dpg Purwa; Meliana, Grace; Putra, I Gusti Ngurah Purna; Widyadharma, I Putu Eka

doi:10.3889/oamjms.2020.3403

Cited by 1 publication

(1 citation statement)

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“…Brain activity evoked by auditory stimulation has been studied for many decades and remains not only commonly used in cognitive neuroscience (Wagner et al 2017 ; Parviainen et al 2019 ) but also clinically relevant (Paulraj et al 2015 ; Samatra et al 2020 ). In humans, the sequence of neural activation evoked by auditory stimulation can be measured using electroencephalography (EEG) or magnetoencephalography (MEG), and the surface-recorded responses are typically divided into three categories based on their latency.…”

Section: Introductionmentioning

confidence: 99%

Neural Mechanisms Underlying Human Auditory Evoked Responses Revealed By Human Neocortical Neurosolver

2021

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Auditory evoked fields (AEFs) are commonly studied, yet their underlying neural mechanisms remain poorly understood. Here, we used the biophysical modelling software Human Neocortical Neurosolver (HNN) whose foundation is a canonical neocortical circuit model to interpret the cell and network mechanisms contributing to macroscale AEFs elicited by a simple tone, measured with magnetoencephalography. We found that AEFs can be reproduced by activating the neocortical circuit through a layer specific sequence of feedforward and feedback excitatory synaptic drives, similar to prior simulation of somatosensory evoked responses, supporting the notion that basic structures and activation patterns are preserved across sensory regions. We also applied the modeling framework to develop and test predictions on neural mechanisms underlying AEF differences in the left and right hemispheres, as well as in hemispheres contralateral and ipsilateral to the presentation of the auditory stimulus. We found that increasing the strength of the excitatory synaptic cortical feedback inputs to supragranular layers simulates the commonly observed right hemisphere dominance, while decreasing the input latencies and simultaneously increasing the number of cells contributing to the signal accounted for the contralateral dominance. These results provide a direct link between human data and prior animal studies and lay the foundation for future translational research examining the mechanisms underlying alteration in this fundamental biomarker of auditory processing in healthy cognition and neuropathology.

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