The Difference in Location between Traumatic Cerebral Microbleeds and Microangiopathic Microbleeds Associated with Stroke

Imaizumi, Toshio; Miyata, Kei; Inamura, Shigeru; Kohama, Ikuhide; Nyon, Kim Sang; Nomura, Tatsufumi

doi:10.1111/j.1552-6569.2011.00593.x

Cited by 22 publications

(13 citation statements)

References 28 publications

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“…In our case, the clinical course suggested that a mild head injury may have caused the CMB. Traumatic CMBs tend to occur in subcortical white matter, while hypertension-related CMBs tend to occur in the basal ganglia or thalamus [2,12]. This characteristic distribution pattern is in agreement with our case.…”

Section: Discussionsupporting

confidence: 92%

Rapidly Progressive Cognitive Disturbances Due to Nonconvulsive Status Epilepticus Associated with a Cerebral Microbleed: Clinical Application of FDG-PET

Nakagami

Sugihara

Uemura

et al. 2014

E&S

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Cerebral microbleeds (CMBs) usually produce no symptoms. We encountered a patient who developed cognitive decline and psychotic symptoms associated with nonconvulsive status epilepticus (NCSE), with presumptive epileptogenic focus possibly caused by a CMB. A 70-year-old man developed progressive cognitive disturbances including disorientation and hallucinations two months after a mild head injury. He was admitted to our hospital three months after the trauma, because of progression of symptoms. Vol.7 No.1 (2014) Epilepsy & Seizure Journal of Japan Epilepsy Society

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Section: Discussionsupporting

confidence: 92%

Rapidly Progressive Cognitive Disturbances Due to Nonconvulsive Status Epilepticus Associated with a Cerebral Microbleed: Clinical Application of FDG-PET

Nakagami

Sugihara

Uemura

et al. 2014

E&S

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“…54,[68][69][70][71][72][73][74][75][76][77][78][79][80][81] CMBs are usually associated with small vessel disease such as CAA but they can also appear in a variety of other conditions including but not limited to: hemorrhagic stroke, hypertensive vasculopathy, lacunar infracts, TBI, and part of the natural aging process. They are often thought to imply an increased risk for intracranial hemorrhage and evidence is growing that the CMB lesion load is associated with cognitive decline, especially as this relates to dementia.…”

Section: Susceptibility-weighted Imaging and Quantitative Susceptibilmentioning

confidence: 99%

Evaluating the Role of Reduced Oxygen Saturation and Vascular Damage in Traumatic Brain Injury Using Magnetic Resonance Perfusion-Weighted Imaging and Susceptibility-Weighted Imaging and Mapping

Kou

Haacke³

2015

Topics in Magnetic Resonance Imaging

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The cerebral vasculature, along with neurons and axons, is vulnerable to biomechanical insult during traumatic brain injury (TBI). Trauma-induced vascular injury is still an underinvestigated area in TBI research. Cerebral blood flow and metabolism could be important future treatment targets in neural critical care. Magnetic resonance imaging offers a number of key methods to probe vascular injury and its relationship with traumatic hemorrhage, perfusion deficits, venous blood oxygen saturation changes, and resultant tissue damage. They make it possible to image the hemodynamics of the brain, monitor regional damage, and potentially show changes induced in the brain's function not only acutely but also longitudinally following treatment. These methods have recently been used to show that even mild TBI (mTBI) subjects can have vascular abnormalities, and thus they provide a major step forward in better diagnosing mTBI patients.

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“…Hemorrhages in a lobar, cortico-subcortical distribution are associated with Apolipoprotein E (APOE) ε2 (35) and APOE ε4 carrier status (16, 34), β-amyloid burden on 11 C-PiB positron emission tomography (PET) (36), and evidence of CAA at post-mortem (32). In the setting of trauma, microbleeds have been reported more frequently in mid-subcortical cerebrum, above the corpus callosum, whereas non-traumatic microbleeds were found in lateral subcortical areas, basal ganglia, and thalamus (37). Microbleeds in the cerebellum have been associated with both presence of CAA and with arteriosclerotic disease (38).…”

Section: Introductionmentioning

confidence: 99%

Cerebral Microbleeds: A Review of Clinical, Genetic, and Neuroimaging Associations

et al. 2014

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Cerebral microbleeds (microbleeds) are small, punctuate hypointense lesions seen in T2* Gradient-Recall Echo (GRE) and Susceptibility-Weighted (SWI) Magnetic Resonance Imaging (MRI) sequences, corresponding to areas of hemosiderin breakdown products from prior microscopic hemorrhages. They occur in the setting of impaired small vessel integrity, commonly due to either hypertensive vasculopathy or cerebral amyloid angiopathy. Microbleeds are more prevalent in individuals with Alzheimer’s disease (AD) dementia and in those with both ischemic and hemorrhagic stroke. However they are also found in asymptomatic individuals, with increasing prevalence with age, particularly in carriers of the Apolipoprotein (APOE) ε4 allele. Other neuroimaging findings that have been linked with microbleeds include lacunar infarcts and white matter hyperintensities on MRI, and increased cerebral β-amyloid burden using 11C-PiB Positron Emission Tomography. The presence of microbleeds has been suggested to confer increased risk of incident intracerebral hemorrhage – particularly in the setting of anticoagulation – and of complications of immunotherapy for AD. Prospective data regarding the natural history and sequelae of microbleeds are currently limited, however there is a growing evidence base that will serve to inform clinical decision-making in the future.

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The Difference in Location between Traumatic Cerebral Microbleeds and Microangiopathic Microbleeds Associated with Stroke

Abstract: There are substantial differences in locations of MB development in trauma patients in comparison to stroke patients.

Cited by 22 publications

References 28 publications

Rapidly Progressive Cognitive Disturbances Due to Nonconvulsive Status Epilepticus Associated with a Cerebral Microbleed: Clinical Application of FDG-PET

Rapidly Progressive Cognitive Disturbances Due to Nonconvulsive Status Epilepticus Associated with a Cerebral Microbleed: Clinical Application of FDG-PET

Evaluating the Role of Reduced Oxygen Saturation and Vascular Damage in Traumatic Brain Injury Using Magnetic Resonance Perfusion-Weighted Imaging and Susceptibility-Weighted Imaging and Mapping

Cerebral Microbleeds: A Review of Clinical, Genetic, and Neuroimaging Associations

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