The Dietary Effects of Some Ecdysteroids on the Development of Housefly

Singh, Pritam; Russell, Graeme B.; Fredericksen, Susan

doi:10.1111/j.1570-7458.1982.tb03174.x

Cited by 12 publications

(1 citation statement)

References 18 publications

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“…The moulting abnormalities caused by the extracts appeared to be identical to those seen with the L. intermedius compounds 20-hydroxyecdysone, 5,20-dihydroxyecdysone, and ponasterone A. Singh et al (1982) found that when added to an amino acid diet, 20-hydroxyecdysone, 5,20-dihydroxyecdysone, and dacrysterone gave 84,77, and 52% larval mortality respectively in M. domestica at 100 ppm after 10 days. Although the serum-based assay used in this study has only a 1 -day duration, the results indicate that sensitivity of L. cuprina larvae to the phytoecdysones is similar to that of M. domestica.…”

Section: Discussionmentioning

confidence: 54%

Activity of extracts and compounds from New Zealand gymnosperms against larvae ofLucilia cuprina(Diptera: Calliphoridae)

Gerard

Ruf

Lorimer

et al. 1997

New Zealand Journal of Agricultural Research

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A modified serum-based bioassay was used to screen plant extracts and assess compound activity against newly hatched larvae of the Australian sheep blowfly Lucilia cuprina. Larval instar mortality and physical appearance were recorded after exposure for 24 h to the treatments. Extracts from New Zealand gymnosperms shown to have activity against L. cuprina larvae were: Podocarpus totara; P. acuteafolius; Dacrycarpus dacrydioides; Halocarpus bidwillii; H. biformis; H. kirkii; Lagarostrobos colensoi; Lepidothamnus intermedius; L. laxifolius; Phyllocladus trichomanoides; P. glaucus, and Agathis australis. The phytoecdysones 20-hydroxyecdysone, 5,20-dihydroxyecdysone, and ponasterone A inhibited larval moulting. Dyshomoerythrine, dacrysterone, and nagilactone C were insecticidal, with the latter also retarding growth at sublethal rates.

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Section: Discussionmentioning

confidence: 54%

Activity of extracts and compounds from New Zealand gymnosperms against larvae ofLucilia cuprina(Diptera: Calliphoridae)

Gerard

Ruf

Lorimer

et al. 1997

New Zealand Journal of Agricultural Research

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Action of RH 5849, a non‐steroidal ecdysteroid mimic, on Plodia interpunctella (Hübner) in vivo and in vitro

Silhacek

Oberlander

Porcheron

1990

Arch Insect Biochem Physiol

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In memory of Christa L. Hoyt We have examined the effects of RH 5849, a lion-steroidal ecdysteroid mimic, on the growth and development of Plodia inferpuncteila. When R H 5849 was administered in the diet, larval growth was inhibited in a dose-dependent manner, while concentrations of 15 ppm and greater were highly toxic. However, the deleterious effects of RH 5849 could be prevented, except at very high concentrations of RH 5849, by the simultaneous administration of the juvenile hormone mimic methoprene. Larvae simultaneously treated with both hormone mimics continued to grow until they attained a size about three times normal. This growth was accompanied by at least one and sometimes two supernumerary molts, whereas, only an occasional supernumerary molt occurred in larvae treated with methoprene alone. In larvae undergoing supernumerary molts, wing imaginal discs produced a tanned pupal cuticle, but did not evaginate. When wing discs were cultured in vitro, RH 5849 stimulated evagination and chitin synthesis at concentrations of 10 and 1 pM, respectively. Likewise, RH 5849 stimulated GlcNAc uptake and inhibited cellular proliferation in IAL-PID2 cells at similar concentrations. These in vitro effects of RH 5849 also were produced by 20-hydroxyecdysone, but at lower concentrations. We conclude that RH 5849 exhibits molting hormone activity in vivo as well as in vitro. However, the toxicological effects in /? interpunctella result from action on feeding and growth, rather than molting. Thus, RH 5849 represents a new class of IGR, which will have impact on our understanding of endocrine regulation and open up new avenues for pest control.

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