The Diet of Higher Insulinemic Potential Is Not Associated with Worse Survival in Patients with Stage III Colon Cancer (Alliance)

Abstract

Background: Hyperinsulinemia is considered to be important in the development of colon cancer, but few studies have investigated the associations of hyperinsulinemia with colon cancer survival via dietary scores.Methods: Empirical dietary index for hyperinsulinemia (EDIH) was derived to assess the insulinemic potential of daily diets reflecting the long-term insulin exposure, with higher (more positive) scores indicating higher insulinemic diets. We prospectively estimated the HRs and 95% confidence intervals (CI) to investigate the association of EDIH with disease-free, recurrence-free, and overall survival among patients with stage III colon cancer (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009) enrolled in a randomized adjuvant chemotherapy trial (CALGB 89803).Results: Of 1,024 patients (median follow-up: 7.3 years), 311 died, 350 had recurrences, and 394 had events for disease-free survival. Compared with patients in the lowest quintile of EDIH, the corresponding HRs of patients in the highest quintile for diseasefree survival events, cancer recurrence, and overall mortality were 0.80 (95% CI, 0.56-1.15), 0.76 (95% CI, 0.51-1.11), and 0.77 (95% CI, 0.52-1.14).Conclusions: Higher EDIH was not associated with the risk of colon cancer recurrence or mortality in this population of patients with stage III colon cancer.Impact: EDIH, as a measure of dietary insulinemic potential, may be associated with colon cancer risk but not survival in patients with late-stage colon cancer.

Higher dietary insulinaemic potential is associated with increased risk of liver steatosis and fibrosis

“…its development is data-driven) to assess the insulinaemic potential of habitual diet and have been suggested to be associated with multiple health outcomes including several sitespecific cancers, [16][17][18] type 2 diabetes, 19 weight gain 20 and survival among patients with colorectal cancer. 21,22 To date, however, there has been no epidemiological studies investigating the association of EDIH or EDIR with the risk of hepatic steatosis and fibrosis. In addition, the EDIH and EDIR indices by Tabung et al 15 were derived based on populations from matched case-control studies within 3…”

The relationship between the insulinemic potential of diet and lifestyle and risk of breast cancer: a case-control study among iranian adult women

“…Although EDIR was associated with increased multiple myeloma risk in another study, EDIH did not show any significant relationship with the risk of multiple myeloma [ 13 ]. Although Cheng et al declared that a higher score of EDIH is potentially related to colon cancer risk, no significant association was observed between a potential insulinemic diet and the risk of colon cancer recurrence, survival, or mortality in patients with late-stage (III) colon cancer [ 22 ]. EDIH, EDIR, ELIH, and ELIR are indicators that have been implicated in the pathogenesis of various cancer and complications [ 23 , 24 ].…”

Post‐diagnosis dietary factors, supplement use and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis

“…Fifteen studies (38%) (47 publications) were from North America 33,36,[75][76][77]80,[82][83][84][85][86][87][89][90][91]93,94,[96][97][98][99][100][101][102][103][104][105][106][107][108][109][110][111][114][115][116][117][118][119][120][121]123,124,127,131,135,136 and eleven (26%) (13 publications) were from Europe, 35,37,74,79,…”

“…One (2%) study included stage II patients only, 33 three (8%) (16 publications) stage III only, 82,86,91,93,96,97,99,100,103,105,109,116,118,119,123,127 two (5%) (5 publications) locally advanced or metastatic stage only, 76,77,84,107,131 and seven (18%) (5 publications) 36,75,122,133,136 stage IV only. Study size ranged from 100 to 2910 participants (median 611 participants).…”