The dichotomy in the DNA-binding behaviour of ruthenium(II) complexes bearing benzoxazole and benzothiazole groups

Synthesis and characterization of chiral ruthenium(II) complexes Λ/Δ-[Ru(bpy)2(H2iip)](ClO4)2 as stabilizers of c-myc G-quadruplex DNA

“…These data suggested that the Λ-isomer binds with c-myc G4 DNA with subtle but detectable higher affinity than that of the Δ-isomer [36].…”

Selected Pharmacological Applications of 1<sup>st</sup> Row Transition Metal Complexes: A review

“…Several azomethines were reported to possess important biological activities [70][71]. In many cases, beside the N-donor atoms, there are several other donor atoms such as O and S in the backbones of the ligands such that they can be coordinated to transition metal ions in the various modes to form the stable metal complexes [72][73][74][75][76][77][78][79][80][81][82][83][84][85]. These ligands are not only used in the development of coordination chemistry but also find applications in catalysis, optical and bioinorganic chemistry [86].…”

Synthesis, DNA Binding, and Oxidative Cleavage Studies of Fe(II) and Co(III) Complexes Containing Bioactive Ligands

“…Infrared (IR) spectra were recorded with Shimadzu (Bangalore, India) model FTIR spectrophotometer by using KBr pellets. [1] H-NMR spectra were recorded on a Bruker (Bangalore, India) NMR spectrophotometer (400 MHz) at 25 • C in DMSO with tetra methyl silane (TMS) as the internal reference. UV-visible absorption spectra were recorded using Shimadzu model UV-1650PC spectrophotometer at room temperature.…”

“…[1] Many coordination compounds of transition metal ions accomplish nucleolytic cleavage. [2] Studies of mixed ligand transition metal complexes, which bind at specific sites along a DNA strand as reactive models for protein-nucleic acid interaction, provide routes toward rational drug design as well as means to develop sensitive chemical probes for DNA.…”

“…They also have investigated the effect of ligand containing N-N donor atom and hydrogen bonding ability on the DNA binding by cobalt(III) complexes. [7][8][9] These complexes were shown to effectively cleave DNA and involve [1] O 2 or OH as the reactive species. The overall DNA binding and cleavage results obtained for these cobalt(III) complexes were in parallel with those obtained for their parent ruthenium(II) complexes.…”