The diagonal band of Broca is involved in the pressor pathway activated by noradrenaline microinjected into the periaqueductal gray area of rats

Pelosi, Gislaine Garcia; Tavares, Rodrigo Fiacadori; Corrêa, Fernando Morgan de Aguiar

doi:10.1016/j.lfs.2009.01.011

Cited by 3 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The DBB is considered to be part of a central catecholaminergic pathway sensitive to baroreflex activation that also modulates vasopressin release (Jhamandas & Renaud, 1986). Moreover, microinjection of CoCl 2 into DBB reduced significantly the cardiovascular responses evoked by microinjection of NA into the dorsal periaqueductal gray (PAG), showed that DBB is part of the cardiovascular pathway activated by PAG stimulus (Pelosi et al. , 2009).…”

Section: Discussionmentioning

confidence: 99%

The medial amygdaloid nucleus is involved in the cardiovascular pathway activated by noradrenaline into the lateral septal area of rats

Scopinho

Fortaleza

Corrêa

2012

Eur J of Neuroscience

View full text Add to dashboard Cite

We have previously reported that noradrenaline (NA) microinjected into the lateral septal area (LSA) caused pressor and bradicardic responses that were mediated by vasopressin release into the circulation through the paraventricular nucleus of hypothalamus (PVN). Although PVN is the final structure involved in the cardiovascular responses caused by NA in the LSA, there is no evidence of direct connections between these areas, suggesting that some structures could be links in this pathway. In the present study, we verified the effect of reversible synaptic inactivation of the medial amygdaloid nucleus (MeA), bed nucleus of stria terminalis (BNST) or diagonal band of Broca (DBB) with Cobalt Chloride (CoCl(2) ) on the cardiovascular response to NA microinjection into the LSA of unanesthetized rats. Male Wistar rats had guide cannulae implanted into the LSA and the MeA, BNST or DBB for drug administration, and a femoral catheter for blood pressure and heart rate recordings. Local microinjection of CoCl(2) (1 mm in 100 nL) into the MeA significantly reduced the pressor and bradycardic responses caused by NA microinjection (21 nmol in 200 nL) into the LSA. In contrast, microinjection of CoCl(2) into the BNST or DBB did not change the cardiovascular responses to NA into the LSA. The results indicate that synapses within the MeA, but not in BNST or DBB, are involved in the cardiovascular pathway activated by NA microinjection into the LSA.

show abstract

Section: Discussionmentioning

confidence: 99%

The medial amygdaloid nucleus is involved in the cardiovascular pathway activated by noradrenaline into the lateral septal area of rats

Scopinho

Fortaleza

Corrêa

2012

Eur J of Neuroscience

View full text Add to dashboard Cite

show abstract

“…Research regarding the mechanisms of the cholinergic activation of the hippocampus has focused on nicotinic acetylcholine receptors in the hippocampus in human brain diseases, such as Alzheimer's disease and schizophrenia (reviews by Yakel, ; Bell et al, ). The horizontal diagonal band of Broca has also been implicated in central cardiovascular regulation (Hatam and Nasimi, ; Nasimi and Hatam, ; Tavares et al, ; Crestani et al, ), including the pressor pathway (Pelosi et al, ).…”

Section: Introductionmentioning

confidence: 99%

Volumetric analysis of the diagonal band of Broca in patients with schizophrenia and affective disorders: A post‐mortem study

et al. 2015

View full text Add to dashboard Cite

The human diagonal band of Broca is connected to other parts of the limbic system, such as the hippocampus, that are involved in the pathology of schizophrenia. This study aimed to characterize the volume and anterior-to-posterior distance of the human diagonal band of Broca (vertical limb) from post-mortem brains obtained from three groups: healthy control subjects (N = 17), patients with schizophrenia (N = 26), and patients with affective disorders (N = 12). There were no significant differences in the volume or anterior-to-posterior distance in the patients with schizophrenia or affective disorders compared with the healthy control subjects. To date, this is the first post-mortem investigation measuring the volume and the anterior-to-posterior distance of the diagonal band of Broca (vertical limb) in patients with schizophrenia or affective disorders compared with healthy control subjects.

show abstract

Neuromodulation with chemicals: Opportunities and challenges

Pan,

Mao

et al. 2024

Fundamental Research

View full text Add to dashboard Cite

The diagonal band of Broca is involved in the pressor pathway activated by noradrenaline microinjected into the periaqueductal gray area of rats

Cited by 3 publications

References 29 publications

The medial amygdaloid nucleus is involved in the cardiovascular pathway activated by noradrenaline into the lateral septal area of rats

The medial amygdaloid nucleus is involved in the cardiovascular pathway activated by noradrenaline into the lateral septal area of rats

Volumetric analysis of the diagonal band of Broca in patients with schizophrenia and affective disorders: A post‐mortem study

Neuromodulation with chemicals: Opportunities and challenges

Contact Info

Product

Resources

About