The diagnostic value of systemic immune-inflammation index in diabetic macular oedema

Elbeyli, Ahmet; Kurtul, Bengi Ece; Özcan, Sait Coşkun; Özcan, Deniz Özarslan

doi:10.1080/08164622.2021.1994337

Cited by 31 publications

(38 citation statements)

References 21 publications

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“…Unfortunately, novel systemic inflammatory markers were not studied in that work. Elbeyli et al [31] demonstrated that elevated SII is strongly associated with the occurrence of DME using data from patients with non-proliferative diabetic retinopathy, which agrees with our conclusion that DME is associated with systemic inflammation. O ¨zata Gu ¨ndog ˘du et al [32] found that SII levels were significantly higher in DME with SRF, which is consistent with our results, as is shown in Fig.…”

Section: Discussionsupporting

confidence: 92%

“…1, and no other OCT biomarkers were studied in their work. However, in Elbeyli et al's study [31], there was no significant difference in systemic inflammatory markers between patients with DME with or without SRF. According to previous research, it is suggested that SRF presence is associated with elevated pro-inflammatory cytokines in aqueous humor [42] and intravitreal corticosteroid injection is an effective treatment for subretinal fluid resolution [43].…”

Section: Discussionmentioning

confidence: 79%

“…Nowadays, some easily obtained novel blood inflammatory markers, including systemic immune-inflammatory index (SII), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR), have been correlated with multiple inflammation-related diseases such as stroke [28], cardiovascular diseases [29], and cancer [30]. Recently, Elbeyli et al reported that an elevated SII value is strongly associated with the presence of DME [31]. O ¨zata Gu ¨ndog ˘du et al found that NLR and SII levels were significantly higher in DME with SRF [32].…”

Section: Introductionmentioning

confidence: 99%

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OCT-Based Biomarkers are Associated with Systemic Inflammation in Patients with Treatment-Naïve Diabetic Macular Edema

et al. 2022

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This cross-sectional study aimed to comprehensively investigate the association between optical coherence tomography (OCT) biomarkers and systemic inflammation in patients with diabetic macular edema (DME), which is short of research and well worth attention.This study found that hyperreflective foci (HRF) are positively associated with systemic immune-inflammatory index (SII) in multivariable regression models, while other OCT biomarkers are not significantly related to systemic inflammation in the current study.Systemic inflammatory markers might be helpful for DME classification and treatment decision.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

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OCT-Based Biomarkers are Associated with Systemic Inflammation in Patients with Treatment-Naïve Diabetic Macular Edema

et al. 2022

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“…Fourth, blood samples were collected preoperatively, and the change in SII during the pathogenesis of OLF was not confirmed given the retrospective design of this study. Fifth, some of the included patients were diagnosed with hypertension or diabetes, which might affect the SII results [ 48 , 49 ]. Multicenter prospective studies with strict methodologies and large populations should be conducted to further determine the relationship between SII and OLF and explore its underlying mechanism.…”

Section: Discussionmentioning

confidence: 99%

High Systemic Immune-Inflammation Index and Body Mass Index Are Independent Risk Factors of the Thoracic Ossification of the Ligamentum Flavum

Zhao

Xiang

Lin

et al. 2022

Mediators of Inflammation

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Background. Inflammation has been considered to play an important role in the pathogenesis of the thoracic ossification of the ligamentum flavum (OLF). However, the inflammation-related risk factors of thoracic OLF have not been fully investigated to date. Methods. A total of 95 patients (48 in the OLF group and 47 in the control group) were included in this retrospective study to explore the independent risk factors of thoracic OLF. The following demographic and clinical variables were compared between the two groups: gender, age, body mass index (BMI), coexistence of hypertension or diabetes, and inflammation-related variables. Multivariate logistic regression analysis was utilized to determine the independent risk factors. Results. High systemic immune-inflammation index (SII) (≥621) (odds ratio OR = 12.16 , 95% confidence interval CI = 2.95 – 50.17 , p < 0.01 ) and BMI (≥25 kg/m2) ( OR = 9.17 , 95 % CI = 3.22 – 26.08 , p < 0.01 ) were independent risk factors of thoracic OLF. SII ( R = 0.38 , p < 0.01 ) and BMI ( R = 0.46 , p < 0.01 ) were positively associated with OLF score. Conclusion. High SII and BMI were the independent risk factors of thoracic OLF. Multicenter prospective studies with a large population should be conducted in the future to verify our findings.

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“…Elbeyli et al [ 31 ] indicated that SII is a superior marker to determine diabetic macular edema in diabetic retinopathy compared to NLR and PLR. Kurtul et al [ 32 ] examined the usefulness of NLR, PLR, and SII in determining disease severity and activity in noninfectious uveitis.…”

Section: Discussionmentioning

confidence: 99%

Systemic immune-inflammation index could be associated with pseudophakic cystoid macular edema after an uneventful phacoemulsification surgery in patients without risk factors

2022

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Background To evaluate the association between serum biomarkers and pseudophakic cystoid macular edema (PCME) in eyes without risk factors after uneventful phacoemulsification cataract surgery. Methods This is a case–control study. Patients without risk factors and who developed clinically significant PCME after uncomplicated phacoemulsification surgery were enrolled in the study. The age- and sex-matched control group that had normal fundus examination findings and 10/10 visual acuity in the first week, first month and following postoperative control visits was randomly recruited from the same study cohort. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) were obtained from the preoperative complete blood count (CBC) test and compared between the two groups. Linear regression analysis was used to assess the relationship between central macular thickness (CMT) and biomarkers. A binary logistic regression model was generated to evaluate the significance of the biomarkers in predicting PCME. The receiver operating characteristic (ROC) curves of the significant parameters in the logistic regression model were presented to detect the area under the curve (AUC), the cut-off point, the sensitivity and the specificity. Results The study cohort included 5352 patients. Of these patients, 52 (0.97%) met the inclusion criteria, and 60 age- and sex-matched patients were recruited as the control group. PLR, NLR, and SII were significantly different between the two groups (p = 0.006, p = 0.002, p < 0.001, respectively). According to the linear regression analysis, SII was found to have a significant relationship with CMT (p < 0.001). Only SII was assessed as significant in the logistic regression model (p = 0.046). In the ROC curve, the AUC of SII was 0.709. The sensitivity and specificity of SII for PCME prediction were 65.38% and 75%, respectively, and the cut-off point was 433.70. Conclusion SII is associated with the occurrence of PCME in eyes without risk factors after uneventful phacoemulsification surgery. SII could be a useful tool to predict PCME in eyes without risk factors.

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The diagnostic value of systemic immune-inflammation index in diabetic macular oedema

Cited by 31 publications

References 21 publications

OCT-Based Biomarkers are Associated with Systemic Inflammation in Patients with Treatment-Naïve Diabetic Macular Edema

OCT-Based Biomarkers are Associated with Systemic Inflammation in Patients with Treatment-Naïve Diabetic Macular Edema

High Systemic Immune-Inflammation Index and Body Mass Index Are Independent Risk Factors of the Thoracic Ossification of the Ligamentum Flavum

Systemic immune-inflammation index could be associated with pseudophakic cystoid macular edema after an uneventful phacoemulsification surgery in patients without risk factors

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