The diagnostic value of small bowel wall vascularity after sulfur hexafluoride-filled microbubble injection in patients with Crohn's disease. Correlation with the therapeutic effectiveness of specific anti-inflammatory treatment

Quaia, Emilio; Migaleddu, Vincenzo; Baratella, Elisa; Pizzolato, Riccardo; Rossi, Alexia; Grotto, M; Cova, Maria Assunta

doi:10.1016/j.ejrad.2008.10.029

Cited by 74 publications

(30 citation statements)

References 20 publications

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“…Quaia et al used Qontrast software to assess the value of small bowel wall vascularization after SonoVue injection to evaluate the efficacy of anti-inflammatory therapy in patients with ileal CD. The slope of the first ascending tract of the curve and the area under the enhancement curve were significantly lower after 6 months of treatment (p \ 0.05) and correlated significantly with CDAI score (p \ 0.05) [71]. Another study also showed that the area under the time-intensity curve obtained after microbubbles injection was the only parameter to discriminate between responders and nonresponders among CD patients during pharmacological treatment (p \ 0.05) [72].…”

Section: Ceusmentioning

confidence: 96%

SICUS and CEUS imaging in Crohn’s disease: an update

et al. 2017

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Endoscopy remains the main technique in the diagnosis and treatment of Crohn's disease (CD); nevertheless, the recent development of innovative and non-invasive imaging techniques has led to a new tool in the exploration of small bowel in CD patients. This paper reviews the available data on ultrasound imaging used for the evaluation of CD, highlighting the role of small intestine contrast-enhanced ultrasonography with the use of oral and intravenous contrast agents.Keywords Crohn's disease Á Contrast-enhanced ultrasound Á Small intestine contrast ultrasonography Sommario Nell'iter diagnostico e terapeutico della malattia di Crohn l'endoscopia rappresenta la principale metodica strumentale. Tuttavia, la recente introduzione di tecniche di imaging innovative e non invasive ha implementato lo studio dell'intestino nelle malattie infiammatorie croniche intestinali. La seguente revisione raccoglie i dati disponibili in letteratura relativi all'utilizzo dell'ecografia con mezzo di contrasto, sia orale (SICUS) sia endovenoso (CEUS), nella valutazione dei pazienti affetti da malattia di Crohn.

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Section: Ceusmentioning

confidence: 96%

SICUS and CEUS imaging in Crohn’s disease: an update

et al. 2017

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“…Anti-TNF therapy caused a significant reduction in bowel wall thickness (p = 0.005) and vascularization as determined by Doppler flow (p = 0.02) with the disappearance of the ultrasound parameters in 50% of the patients. Another small study with 15 patients used the SICUS to assess ultrasonography changes caused by anti-inflammatory treatment in relation to clinical response [26]. Significant correlation with CDAI (p < 0.05) was determined.…”

Section: Ultrasonography During Follow-up Of CDmentioning

confidence: 99%

Bowel Ultrasonography in Inflammatory Bowel Disease

Kucharzik¹

2015

Dig Dis

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Background: The diagnosis of inflammatory bowel disease (IBD) is based on a combination of endoscopic, clinical and biochemical investigations as well as cross-sectional imaging. The applications of cross-sectional imaging in IBD are manifold. Ultrasonography has emerged as an important imaging modality in the diagnosis of Crohn's disease (CD) as well as for monitoring disease progression and in the therapeutic response to CD and ulcerative colitis (UC). Key Messages: Ultrasonography is non-invasive, radiation free, cheap, easy to use and well tolerated and accepted by patients. Bowel ultrasonography can be used for the primary diagnosis of CD as it has a similar sensitivity and specificity like that of MRI and CT, particularly in the case of CD. Ultrasonography can also be used to monitor treatment response to therapy and to detect disease recurrence of CD as well as UC. In CD, ultrasonography can also be used to detect complications such as strictures as well as extramural complications, including abscesses and fistulas. Contrast-enhanced ultrasonography is a useful tool that might be helpful to detect certain indications in CD, in particular the differentiation between abscesses and inflammation. Conclusion: A variety of advantages of bowel ultrasonography over other imaging modalities suggest the more frequent use of this method to manage IBD patients in daily practice. Bowel ultrasonography should be a standard tool in IBD centers.

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“…Q-ontrast generates chromatic maps (Figure 1b) of the ROI perfusion patterns, and automatically compensates for motion artifacts during data acquisition. 43 The Q-ontrast analysis of ROI generated curves representing echo-signal intensity vs time (time intensity curves). For all patients time intensity curve parameters, including the slope of the first ascending tract of the curve, the curve shape, time to peak enhancement, the area under the curve, regional blood flow and mean transit time were recorded (Figures 1c-e).…”

Section: Ceus Methodologymentioning

confidence: 99%

“…For all patients time intensity curve parameters, including the slope of the first ascending tract of the curve, the curve shape, time to peak enhancement, the area under the curve, regional blood flow and mean transit time were recorded (Figures 1c-e). 43 In all patients, US and CEUS were performed by a physician with 15 years of experience in US, who is a member and teacher of the Italian School of Basic and Emergency Ultrasound (SIUMB) at the University of Pisa.…”

Section: Ceus Methodologymentioning

confidence: 99%

Prospective qualitative and quantitative non-invasive evaluation of intestinal acute GVHD by contrast-enhanced ultrasound sonography

Benedetti

Bruno

McDonald

et al. 2013

Bone Marrow Transplant

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Intestinal acute GVHD (I-aGVHD) is a life-threatening complication after allografting. Non-invasive bed-side procedures to evaluate extension and treatment response are still lacking. We hypothesized that, during I-aGVHD, contrast-enhanced ultrasound sonography (CEUS) could detect microcirculation changes (MVC) of the bowel wall (BW) and help to monitor treatment response. We prospectively employed CEUS in 83 consecutive patients. Of these, 14 patients with biopsy-proven intestinal GVHD (I-GVHD) were defined as the study group, whereas 16 patients with biopsy-proven stomach GVHD (U-GVHD) without intestinal symptoms, 6 normal volunteers and 4 patients with neutropenic enterocolitis were defined as the control group. All patients were evaluated with both standard ultrasonography (US) and CEUS at the onset of intestinal symptoms, during clinical follow-up and at flare of symptoms. Standard US revealed BW thickening of multiple intestinal segments, useful to determine the extension of GVHD. CEUS showed MVC, which correlated with GVHD activity, treatment response, and predicted flare of intestinal symptoms. US and CEUS findings were superimposable at diagnosis and in remission. CEUS was, however, more sensitive and specific to identify subclinical activity in patients with clinical relevant improvement. These findings were not observed in the control groups. CEUS is a non-invasive, easily reproducible bed-side tool useful to monitor I-aGVHD.

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The diagnostic value of small bowel wall vascularity after sulfur hexafluoride-filled microbubble injection in patients with Crohn's disease. Correlation with the therapeutic effectiveness of specific anti-inflammatory treatment

Cited by 74 publications

References 20 publications

SICUS and CEUS imaging in Crohn’s disease: an update

SICUS and CEUS imaging in Crohn’s disease: an update

Bowel Ultrasonography in Inflammatory Bowel Disease

Prospective qualitative and quantitative non-invasive evaluation of intestinal acute GVHD by contrast-enhanced ultrasound sonography

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