The Diagnostic Value of Serum Ferritin for Telogen Effluvium: A Cross-Sectional Comparative Study

Cheng, Tiantian; Fang, Huijuan; Wang, Yongchao; Wang, Ying; Yang, Zhiyong; Wu, Ruiying; Yang, Dingquan

doi:10.2147/ccid.s291170

Cited by 8 publications

(15 citation statements)

References 13 publications

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“…Hence these cutoff levels should be based on loco‐regional studies instead of extrapolating findings of studies from countries with different diets. Another theory suggests that an upregulation of hepcidin leads to lower iron being available for the hair follicle in order to compensate for the essential iron requirements 28,29 . Paradoxically, some studies have found that low serum ferritin levels are seen in female androgenetic alopecia, but not in telogen effluvium 30 .…”

Section: Methodsmentioning

confidence: 99%

“…Another theory suggests that an upregulation of hepcidin leads to lower iron being available for the hair follicle in order to compensate for the essential iron requirements. 28,29 Paradoxically, some studies have found that low serum ferritin levels are seen in female androgenetic alopecia, but not in telogen effluvium. 30 Hence, more data are needed to ascribe a definitive association of ID with alopecia.…”

Section: Ironmentioning

confidence: 99%

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Role of nutritional supplements in selected dermatological disorders: A review

Sardana

Sachdeva

2021

J of Cosmetic Dermatology

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Background While a plethora of literature continues to be published on the role of nutritional agents both in lay press and indexed journals, the data is not on a firm footing and leaves the dermatologist in a quandry and the patient confused. The various agents include vitamins, minerals, amino acids, antioxidants, diets & gluten. A proper knowledge of the role of nutritional supplements in dermatological diseases can be a useful tool in advising the patients and in certain cases ameliorating the disorder. Patients/Methods Literature review of last 15 years was made using the terms “diet in dermatology,” “nutrition and skin,” “nutritional supplements in dermatology,” “nutritional agents and acne,” “nutritional agents and alopecia,” and “nutritional agents and psoriasis.” Results While there are multiple publications on the use of nutritional supplements for amelioration of skin diseases, most of them are based on either associations or in vitro studies, but very few transcend the rigors of a clinical trial or the holey grail of a double‐blinded randomized controlled trial. There seem to be some evidence in acne, psoriasis, telogen effluvium, urticaria & vitiligo. Coeliac disease and dermatitis herpetiformis have a strong link with diet. Rosacea has a strong link with certain foods, but the other disorders like melasma, aphthous stomatitis do not have any scientifically validated association with diet. Conclusions Our updated review examines the role of nutritional supplements and antioxidants in various dermatological disorders. We have found that there are varying levels of evidence with notable associations of low glycemic diet & acne, fish oil & weight loss with psoriasis, fish oils & probiotics with atopic dermatitis & vitamins & botanical extracts with vitiligo. The evidence for diet and nutrition in bullous disorders and photoageing is scarce. The role of low histamine diet in urticaria is useful in select cases of episodic urticaria. Rosacea is triggered by hot and spicy food . Apart from gluten and Dermatitis Herpetiformis, no diet can be considered disease modifying in our reveiw. The lack of comparison of nutritional or dietary modiffication with conventional validated agents, makes the data difficult to translate in real world patient management.

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Section: Methodsmentioning

confidence: 99%

Section: Ironmentioning

confidence: 99%

Role of nutritional supplements in selected dermatological disorders: A review

Sardana

Sachdeva

2021

J of Cosmetic Dermatology

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“…1,3,44 Androgenetic alopecia AGA, often called male pattern baldness, is an autosomal dominant disorder that gradually transforms terminal hairs into intermediate and vellus hairs. [45][46][47] It is the most common progressive baldness in both men and women; however, clinical symptoms differ between genders. In men, AGA causes gradual thinning and vertex loss; in women, hair loss affects the frontal scalp and vertex, while the frontal hairline is spared, resulting in a more visible scalp.…”

Section: Non-scarring Alopeciamentioning

confidence: 99%

An Update on Alopecia and its Association With Thyroid Autoimmune Diseases

Aboalola,

Aouabdi,

Ramadan

et al. 2023

touchREVIEWS in Endocrinology

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Alopecia is comorbid with several illnesses, including various autoimmune conditions such as thyroid disease. Leukocyte-mediated inflammation of hair follicles in alopecia was first described over a century ago. However, the high prevalence of the role of thyroid autoimmune disease in the pathogenesis of alopecia has only recently come to light, together with a strong association between the two. Therefore, this review focuses on articles published between 2011 and 2022 on alopecia's association with thyroid autoimmune disease, and the mechanism behind it. In addition, it highlights the link between alopecia and thyroid cancer, as patients with alopecia have increased risk of thyroid cancer. In conclusion, this comprehensive, focused, scoping review will serve as a reference highlighting recent information on alopecia, exploring its association with thyroid autoimmune diseases.

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“…7 Iron also upregulates certain genes like CDC2, NDRG1, ALAD, RRM2 in the bulge region of hair follicle, which promote hair re-growth, affected by iron deficiency. 8 Iron supplementation has been suggested prior to and parallel to care. 9 Haemoglobin levels are not representative of true iron status in females with diffuse hair loss.…”

Section: Introductionmentioning

confidence: 99%

Association of serum ferritin with chronic diffuse alopecia in female patient

Tanjina Nasrin,

Md Abdul Wahab,

Esrat Khan Lubna

et al. 2024

World J. Adv. Res. Rev.

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Background: Diffuse alopecia is a psycho-social stressor on human life. As iron is involved in crucial physiological processes within the hair follicle, iron deficiency is suspected to disrupt hair growth. Chronic telogen effluvium (CTE) and female pattern hair loss (FPHL) are the most common causes of chronic diffuse alopecia in females. In both conditions, low iron store have been considered as a possible contributing factor. Materials and Methods: This was a hospital-based case control study, conducted in the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU) to evaluate the association of serum ferritin with chronic diffuse alopecia in female patient. Results: The mean age of the females with chronic diffuse hair loss was 26.83±7.78 year and 92.9% females had serum ferritin level <30 ng/ml. The mean serum ferritin level in females with chronic diffuse hair loss, CTE and FPHL were 16.3±11.61 ng/ml,12.35±7.15 ng/ml and 20.25±16.07 ng/ml respectively, which were lower than control 54.37±26.07 ng/ml. A highly significant (p<0.001) difference found in the mean serum ferritin level between the groups. In females with CTE, 42.5% had serum ferritin level < 12ng/ml (iron deficient) and 37.5% had 12-20 ng/ml (iron depletion). In females with FPHL, 23.3% and 30% patients had serum ferritin level <12 ng/ml and 12-20ng/ml respectively. Conclusion: This study found the level of serum ferritin were significantly low in females with chronic diffuse hair loss both in chronic telogen effluvium (CTE) and female pattern hair loss (FPHL), indicating there is a definite association of decreased iron store and diffuse hair loss.

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The Diagnostic Value of Serum Ferritin for Telogen Effluvium: A Cross-Sectional Comparative Study

Cited by 8 publications

References 13 publications

Role of nutritional supplements in selected dermatological disorders: A review

Role of nutritional supplements in selected dermatological disorders: A review

An Update on Alopecia and its Association With Thyroid Autoimmune Diseases

Association of serum ferritin with chronic diffuse alopecia in female patient

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