The Diagnostic Value of Scube1 in Patients Presenting to the Emergency Department Due to Angina Pectoris

Şahin, Ali; Turkmen, Süha; Menteşe, Ahmet; Karahan, Süleyman Caner; Günaydın, Mücahit; Türedi, Süleyman; Gunduz, Abdülkadir

doi:10.24938/kutfd.372255

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…In addiditon they found that serum triglyceride levels increased but glucose levels decreased in the obese group and both triglyceride and glucose levels exhibited no significant difference between the control and obese groups 28 . Dai et al observed that plasma SCUBE1 levels were higher in cases of acute coronary syndrome and acute ischemic stroke compared to the control group, whereas Şahin et al did not identify a statistically significant correlation 29,30 . In the current study, we found that SCUBE 1, triglyceride and glucose levels were higher in obese and DM rats.…”

Section: Discussionmentioning

confidence: 97%

SCUBE-1 in The Diagnosis and Follow-Up Of Subclinical Atherosclerosis in The Experimental Diabetes Mellitus and Obesity Model

KÖK,

ASLANKOÇ,

ÖZMEN

et al. 2023

Preprint

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ABSCTRACTBACKGROUNDObesity and diabetes mellitus (DM) is a metabolic disease that is a global problem, the most crucial complication of which is atherosclerotic cardiovascular disease resulting from endothelial dysfunction and accompanying platelet hyperactivity. The presence of the SCUBE-1 protein has been observed within vascular endothelial cells and platelets, both recognized for their pivotal involvement in the arterial thrombosis mechanism. The objective of this research is to examine the utility of serum SCUBE-1 levels in diagnosing and monitoring subclinical atherosclerosis in experimentally induced DM and obese rats.METHODSThe study comprised a cohort of 28 male Sprague‒Dawleyrats, which encompassed the following groups: the obese group subjected to a high-fat diet (HFD), the TII-DM group administered HFD in combination with a single dose of streptozocin (STZ), the TI-DM group treated solely with STZ, and the control group. Serum SCUBE1 was analyzed using the enzyme-linked immunosorbent assay method, and caspase-3 (Cas-3), interleukin-6 (IL-6), interferon-gamma (INF-gamma) and superoxide dismutase (SOD) expression in the liver and pancreas of rats were evaluated using immunohistochemical methods.RESULTSSerum SCUBE1 levels were significantly higher in the obese and DM groups than in the control group, but there was no significant difference among the obese, TI-DM and TII-DM groups. The study identified a significant relationship between serum SCUBE1 level and hepatic CAS3, IL-6 and SOD expression and pancreatic SOD expression.CONCULISONSCUBE1 can be used as a promising novel marker for the diagnosis and monitoring of subclinical atherosclerosis in individuals with obesity, TI-DM, and TII-DM

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Section: Discussionmentioning

confidence: 97%

SCUBE-1 in The Diagnosis and Follow-Up Of Subclinical Atherosclerosis in The Experimental Diabetes Mellitus and Obesity Model

KÖK,

ASLANKOÇ,

ÖZMEN

et al. 2023

Preprint

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Acil Serviste Tanı Alan Stmı ve Nstmı Hastalarda Troponin Değerleri ve Scube 1 Değerlerinin Tanısal Karşılaştırılması

Özmen

Sultanoğlu

Çavuş

et al. 2021

Konuralp Tıp Dergisi

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Objective: In the present study we aimed to compare the levels of troponin and SCUBE 1 markers to determine the diagnostic role of SCUBE 1 in patients with STEMI-NSTEMI. Methods: This study was prospectively conducted with 119 patients diagnosed with acute myocardial infarction at the emergency department of DışkapıYıldırımBeyazıt Training and Research Hospital and 30 control subjects between 01.10.2016 and 01.02.2017. The relationship between age, sex, acute myocardial infarction (AMI) type, white blood cell (WBC), lymphocyte, neutrophil, neutrophil/lymphocyte ratio, red cell distribution width (RDW), thrombocyte count, aspartate aminotransferase (AST), alanine aminotransferase (ALT), CK, CK-MB, troponin, and SCUBE 1 level was examined. Age, sex, and SCUBE 1 level were compared between the patient and control groups. Results: The patients had a mean age of 61.5±14.5 years, and 68.9% of them were male. The patients had a SCUBE 1 level of 79.7 ng/mL and the control group 53.2 ng/ml. SCUBE 1 level was comparable between the patients with acute myocardial infarction and the control group (p>0.05). A correlation was found between SCUBE 1 level and age (p>0.05).Women in the patient group had a significantly higher SCUBE 1 level (p<0.05). There was a positive correlation between the WBC, CKMB, and troponin levels, and SCUBE 1 level in the patient group.cor No correlation was found between SCUBE 1 level and neutrophil, lymphocyte, neutrophil/lymphocyte ratio, RDW, platelet, AST, ALT, and CK levels (p>0.05). There was no significant correlation between infarction type and SCUBE 1 level (p>0.05). Conclusions: SCUBE 1 level did not significantly rise in patients with acute myocardial infarction. As the test had lower sensitivity and specificity compared to the other markers, we believe that it is not suitable for practical use.

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Evaluation of Serum Scube-1 Levels and Affecting Factors in Smokers

Karaman

Basat

2022

Ahi Evran Med J

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Aim: Serum signal peptide-CUB-EGF domain-containing protein-1 (SCUBE-1), an indicator of platelet activation, is a biochemical marker used to evaluate the risk for cardiovascular diseases. This study aimed to evaluate the alteration of plasma levels of SCUBE-1 in smokers compared to healthy controls and determine the affecting factors. Materials and Methods: This prospective study was designed as an experimental, single-centered study with a control group. The study included smokers aged 18-65 years who were admitted to the Smoking Cessation Clinic of a tertiary hospital and a control group consisting of healthy volunteers admitted to the Family Medicine Outpatient Clinic and had never smoked. Sociodemographic data of all participants and smoking histories and addiction levels of smokers were questioned. Exhaled carbon monoxide (CO) levels were measured. Plasma SCUBE-1 levels were studied and compared from samples obtained from venous blood. Results: A total of 82 individuals, consisting of the "smoker" patient group (n=44) and the "non-smoker" control group (n=38), were included in the study. While the mean SCUBE-1 value was 1.28±0.70 ng/ml in smokers, it was 1.54±1.09 ng/ml in non-smokers. There was no statistical difference between smokers and non-smokers in terms of SCUBE-1 (p=0.500). There was no statistically significant correlation between SCUBE-1 levels and exhaled CO level, smoking characteristics and addiction levels in smokers. Conclusion: Our study showed that the plasma SCUBE-1 value in smokers did not increase at statistically significant levels compared to the control group. Therefore, it was concluded that it would not be useful in evaluating the risk of cardiovascular diseases and the susceptibility to thrombosis.

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The Diagnostic Value of Scube1 in Patients Presenting to the Emergency Department Due to Angina Pectoris

Cited by 3 publications

References 14 publications

SCUBE-1 in The Diagnosis and Follow-Up Of Subclinical Atherosclerosis in The Experimental Diabetes Mellitus and Obesity Model

SCUBE-1 in The Diagnosis and Follow-Up Of Subclinical Atherosclerosis in The Experimental Diabetes Mellitus and Obesity Model

Acil Serviste Tanı Alan Stmı ve Nstmı Hastalarda Troponin Değerleri ve Scube 1 Değerlerinin Tanısal Karşılaştırılması

Evaluation of Serum Scube-1 Levels and Affecting Factors in Smokers

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