The Diagnostic Value of Routine Papanicolaou Smears for Detecting Endometrial Cancers: An Update

Lai, Chiung Ru; Hsu, Christine D.; Hang, Jen‐Fan; Li, Anna Fen Yau

doi:10.1159/000438975

Cited by 15 publications

(23 citation statements)

References 13 publications

(22 reference statements)

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“…The value of Papanicolaou tests for detection of EC was evaluated in several retrospective studies 3,12–15 . This current research supports the findings of low sensitivity of Papanicolaou tests for detection of EC.…”

Section: Discussionsupporting

confidence: 83%

Does cervicovaginal cytology have a role in the diagnosis and surveillance of endometrial adenocarcinoma?

Kılıç

Yetimalar

Bezircioglu

et al. 2020

Diagnostic Cytopathology

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Objective To examine the role of cervicovaginal cytology in diagnoses and surveillance of the patients with endometrial carcinoma (EC). Methods Patients who underwent EC surgery that included a follow‐up were reviewed retrospectively. The cohort was limited to the patients who had an available cervical cytology result within 12 months before the primary surgery took place. The glandular abnormalities were classified in the following subclassifications: “atypical glandular cells” (AGC)‐not otherwise specified (NOS), AGC‐favor neoplasia, endocervical AIS, and adenocarcinoma. Results A total of 411 patients were eligible for the study. The cervical cytology was found to be normal and recorded as negative for intraepithelial lesion or malignancy in 368 (89.5%) patients. In 43 (10.5%) patients, cervical cytology was interpreted as: AGC‐NOS (n = 11), AGC‐FN (n = 7), adenocarcinoma (n = 20), malignant epithelial tumor (n = 3), and squamous carcinoma (n = 2). During the follow‐up, recurrence was observed in 53 (12.9%) patients. Among six isolated vaginal cuff recurrences, two of the cases presented with malignant cytology, and the additional four cases were suspected during clinical examination. Among women with recurrence (n = 53), there were malignant cytological findings in four of the patients. In the whole population (n = 411), there were four other abnormal cytological findings detected within the surveillance. These four cytology results were nonmalignant and no recurrence was identified. Conclusion There is no significant clinical advantage of cervicovaginal cytology testing before diagnosis or during the surveillance of EC.

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Section: Discussionsupporting

confidence: 83%

Does cervicovaginal cytology have a role in the diagnosis and surveillance of endometrial adenocarcinoma?

Kılıç

Yetimalar

Bezircioglu

et al. 2020

Diagnostic Cytopathology

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“…It is simple, inexpensive, and the required equipment is available at general hospitals. Previous studies have reported that 38-51% of endometrial cancer patients had abnormal Pap smear results and that abnormal cervical cytology was correlated with tumor size, tumor type, depth of invasion, presence of cervical involvement, and presence of lymphovascular invasion (Lai et al, 2015;Serdy et al, 2016).…”

Section: Association Of Abnormal Pap Smear With Occult Cervical Strommentioning

confidence: 97%

Association of Abnormal Pap Smear with Occult Cervical Stromal Invasion in Patients with Endometrial Cancer

Khumthong

Aue-aungkul

Kleebkaow

et al. 2019

Asian Pac J Cancer Prev

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Objective: The purpose of this study was to determine the association between abnormal preoperative Pap smear results and occult cervical stromal invasion in endometrial cancer patients. Methods: Medical records were reviewed of patients with endometrial cancer who had undergone surgical staging at Srinagarind Hospital. Patients with gross cervical involvement, with an unsatisfactory Pap smear, without available Pap smear results, with no cervical intraepithelial lesion/invasive cervical cancer, or who had previously undergone pelvic radiation therapy were excluded. The patients were assigned to one of two groups according their Pap smear results (negative and epithelial cell abnormalities). Logistic regression was used to determine the independent association between an abnormal Pap smear and the risk of cervical stromal invasion. Results: All cervical smears in this study were performed as conventional Pap smears. Smears were abnormal in 50 (21.0%) of the 238 patients enrolled and normal in the remaining 188 (79.0%). The types of Pap smear abnormalities included adenocarcinoma (n=22); atypical endometrial cells (n=2); atypical glandular cells (n=17); high-grade squamous intraepithelial lesions (n=4); atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesions (n=2); and atypical squamous cells of undetermined significance (n=3). After controlling for type of endometrial cancer, abnormal Pap smear results were found to be a significant independent factor that indicated cervical stromal invasion (adjusted OR 2.65; 95% CI 1.35 to 5.21). Conclusion: Endometrial cancer patients with abnormal Pap smears were strongly and independently associated with histopathologically diagnosed cervical stromal invasion.

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“…Exfoliated endometrial cells may be considered to be normal during menstruation and proliferative phases by Pap smear. However, a more comprehensive assessment should be performed if this type of cells are encountered in the postmenopausal women (8). In the literature, some studies have demonstrated that reporting endometrial cells detected in the cervical screening by Pap smear test may be significant with respect to endometrial carcinoma.…”

Section: Introductionmentioning

confidence: 99%

The Role of Papanicolaou Test in the Diagnosis of Endometrial Carcinoma

Turan

Usta²

2019

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Amaç: Pap smear testi, serviks kanseri ve öncü lezyonlarını taramak için en sık kullanılan ve etkili bir tarama yöntemidir. Endometrial karsinomların tanısında Pap smear testinin kullanımı ile ilgili çok az çalışma vardır. Biz bu çalışmada endometrial karsinom tanısı almış hastaların Pap smearlerinde atipik endometrial hücrelerin bulunma oranını ve klinikopatolojik parametrelerle korelasyonunu araştırmayı amaçladık. Hastalar ve Yöntem: Bu çalışmada Ocak 2015-Eylül 2017 yılları arasında endometrial karsinom tanısı konulmuş ve aynı zamanda Pap smear örneklemesi yapılmış hastalar retrospektif olarak incelenmiştir. Endometrial karsinom olgularının histolojik tip, nükleer derece ve Pap smear sonuçları değerlendirilmiştir. Bulgular: Çalışmaya dahil edilen endometrial karsinom tanısı konulmuş 97 hastanın 59'una aynı zamanda smear örneklemesi yapılmıştı. Smear örneklemesi yapılan hastaların yaşları 42-82 yaş aralığındaydı (ortalama57,43±9,08). Hastaların menopoz durumu değerlendirildiğinde 12'si (%20.3) premenopozal ve 47'si (%79.7) postmenopozal durumdaydı. En sık görülen histolojik tip endometrioid olup 51 hastada izlendi (%86.4). 6 hastada seröz (%10), 1 hastada şeffaf hücreli (%1.8) ve 1 hastada müsinöz karsinom (%1.8) mevcuttu. Pap smear sonucu 24 hastada atipik iken (%40.7), 35 hastada normaldi (%59.3). Nükleer derece değerlendirildiğinde 24 hastada derece 1 (%40.7), 25 hastada derece 2 (%42.3), 10 hastada derece 3'tü (%17). Tümör derecesi arttıkça Pap smearlerde atipik endometrial hücre görülme oranı artmaktaydı. Sonuç: Endometrial karsinomlarda pap smear de atipik hücre saptama oranlarının azımsanmayacak kadar yüksek olduğu görüldü. Nonendometrioid ve yüksek dereceli karsinomlarda atipik hücre görülme oranları daha fazlaydı.

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The Diagnostic Value of Routine Papanicolaou Smears for Detecting Endometrial Cancers: An Update

Cited by 15 publications

References 13 publications

Does cervicovaginal cytology have a role in the diagnosis and surveillance of endometrial adenocarcinoma?

Does cervicovaginal cytology have a role in the diagnosis and surveillance of endometrial adenocarcinoma?

Association of Abnormal Pap Smear with Occult Cervical Stromal Invasion in Patients with Endometrial Cancer

The Role of Papanicolaou Test in the Diagnosis of Endometrial Carcinoma

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