The Diagnostic Value of Neutrophil CD64 in Detection of Sepsis in Children

Hassuna, Noha A.; Mousa, Suzan Omar; Hassan, Ebtesam Esmail; Elgezawy, Ebtesam

doi:10.12816/0036806

Cited by 1 publication

(2 citation statements)

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“…Two other studies also reported similar AUC, 0.707 [14] and 0.71 [25]. Relatively different cut-off values were reported in a different study, probably due to different flow cytometry measurement methods [5].…”

Section: Discussionmentioning

confidence: 55%

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CD64 Index as a Predictor of Outcome for Children with Systemic Inflammatory Response Syndrome (SIRS)

Yetti¹,

Herlina²,

Mayetti³

et al. 2019

Proceedings of the Proceedings of the 1st EAI International Conference on Medical and Health Research, ICoMHER November 13-14th

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Sepsis is one of the major causes of mortality and morbidity in children. The study aimed to assess the prognostic value and difference of Neutrophil CD64 index regarding sepsis outcome. Methods of this study were a prospective observational study in 62 children with Systemic Inflammatory Response Syndrome (SIRS) were conducted in ER and Pediatric Ward Dr. M. Djamil Hospital, Padang. We collected blood samples to measure Neutrophil CD64 index and blood cultures were drawn to confirm infection. Patients were observed clinically until discharge from the hospital. Based on the clinical course and laboratory test results, patients were categorized as having unproven sepsis, sepsis, septic shock, and nonsurvivor. The average Neutrophil CD64 index were 1.13±0.32; 1.71±0.23; 2.29±0.71; 2.86±1.10 for unproven sepsis, sepsis, septic shock, and nonsurvivors, respectively. The area under the curve (AUC) for hospital mortality was 0.863. At a cutoff level of 1.705 sensitivity was 71.4% and specificity was 72.9%. Patients with CD64 index level higher than 1.705 had 6.7-fold higher probability of dying. The odd ratio is 6.7 (95% CI 1.79-25.27). Neutrophil CD64 was significantly elevated as a severe outcome of sepsis. This result indicates that neutrophil CD64 may be used as a biomarker for predicting mortality.

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Section: Discussionmentioning

confidence: 55%

“…Sepsis is defined as life-threatening organ dysfunction or systemic inflammatory response syndrome (SIRS) caused by dysregulated host response to infection [3,4]. Its symptoms are similar to SIRS without infection [5]. The disease could progress to severe sepsis or septic shock and mortality.…”

Section: Introductionmentioning

confidence: 99%