The diagnostic value of ischemia-modified albumin in the diagnosis of aortic pathology

Eroğlu, Oğuz; Turkmen, Süha; Menteşe, Ahmet; Altun, Gökalp; Türedi, Süleyman; Eryiğit, Umut; Karahan, Süleyman Caner; Gunduz, Abdülkadir

doi:10.3906/sag-1206-94

Cited by 8 publications

(10 citation statements)

References 26 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eroglu et al (2014) reported that the level of IMA among patients having aortic dissection was more than in healthy individuals. Several mechanisms can be employed to support this concept.…”

Section: Discussionmentioning

confidence: 99%

Ischemia-Modified Albumin, a Novel Predictive Marker of In-Hospital Mortality in Acute Aortic Dissection Patients

Yang

Zhou

et al. 2019

Front. Physiol.

View full text Add to dashboard Cite

BackgroundThis work explored the prognostic prediction capabilities of ischemia-modified albumin (IMA) in patients suffering from acute aortic dissection (AAD).MethodsWe conducted a retrospective analysis using electronic health records. This study included AAD patients admitted to the Second Xiangya Hospital of Central South University from January 2015 to December 2018 in ≤24 h from the onset of symptoms to hospital admission. The levels of IMA were recorded upon admittance and the final was the all-cause mortality during hospitalization.ResultsThis study enrolled 731 AAD patients. Among who, 160 passed away in the course of medication while 571 of them survived. Those who passed away exhibited higher levels of IMA (94.35 ± 26.84 vs. 69.14 ± 14.70, p < 0.001) than the survivors. Following the adjustment confounders, the fully adjusted model showed IMA to be an independent forecastor for in-hospital mortality for AAD patients (OR 1.10, 95% CI 1.08–1.13, p < 0.001). Analysis based on receiver operating characteristic (ROC) revealed that 79.35 μ/ml was the best threshold of IMA level. The area under the curve (AUC) based on this IMA level was 0.854 (95% CI 0.822–0.898) while the specificity and sensitivity to anticipate in-hospital death were 84.8 and 80.6%, respectively.ConclusionAdmission IMA was an independent forecastor for in-hospital mortality among people suffering from AAD.

show abstract

Section: Discussionmentioning

confidence: 99%

Ischemia-Modified Albumin, a Novel Predictive Marker of In-Hospital Mortality in Acute Aortic Dissection Patients

Yang

Zhou

et al. 2019

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…IMA has a low binding capacity to heavy metals such as cobalt, nickel and copper, and this is closely associated with an increase in ROS, ischemia or the hypoxic process [23]. Studies have shown that IMA levels rise in several conditions, including muscle ischemia, aortic pathologies and diabetic retinopathy [24][25][26][27][28].…”

Section: The European Research Journal Volume 5 Issue 2 March 2019mentioning

confidence: 99%

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Eroğlu

Badem

Baççıoğlu

et al. 2019

The European Research Journal

Self Cite

View full text Add to dashboard Cite

Objectives: The severity of inflammation occurring during chronic obstructive pulmonary disease (COPD) is closely associated with oxidative stress. The aim of this study was to investigate the diagnostic value of Thiol/disulphide homeostasis (TDH) and ischemia modified albumin (IMA) levels in evaluating oxidative stress in COPD patients. Methods: This prospective study was performed with COPD patients presenting to the Kırıkkale University Hospital and with healthy volunteers. Subjects' demographic data (age, sex, body mass index, and smoking status), native thiol (NT), total thiol (TT), disulphide (Ds), IMA levels and Ds/NT, Ds/TT and NT/TT ratios were recorded. Statistical analysis was performed with SPSS 21.0 software. Results: One hundred ninety subjects were enrolled in the study, 141 COPD patients and 49 healthy volunteers. No difference was determined between the patient and control groups in terms of age, sex or body mass index. The antioxidant markers; NT and TT levels and NT/TT ratio were significantly lower in the patient group compared to the control group (p < 0.001, p < 0.001, and p < 0.003, respectively). The oxidant markers; IMA levels and Ds/NT and Ds/TT ratios were significantly higher in the patient group (p = 0.006, p = 0.003, and p = 0.003, respectively). Significant negative correlation was determined between antioxidant and oxidant parameters. Sensitivity values were NT: 87.2%, TT: 83.3%, Ds/NT ratio: 68.1%, Ds/TT ratio: 68.1%, and IMA: 77.8%. Conclusions: TDH was impaired in favor oxidants in COPD patients. TDH parameters and IMA can be used to monitor oxidative stress emerging in COPD.

show abstract

“…A previous study reported that there was no difference between the IMA levels in the aortic dissection and aneurysm groups compared to the healthy control group [22]. Conversely, a study by Eroğlu et al demonstrated that the IMA levels were higher in the aortic aneurysm group than the control group [23]. These contradictory results may be due to the differences in number, age, demographic characteristics, sex, and race of the patients included in the studies.…”

Section: Discussionmentioning

confidence: 93%

“…In studies of coronary artery disease, the IMA levels increased immediately after exposure to ischemia and decreased to normal levels within 12 hours [22]. Another reason that may explain this difference may be the rate of exposure to physiological variables, which significantly affects the IMA levels [23]. Finally, it may be necessary to have more severe oxidative damage, such as ischemia, acidosis, or tissue hypoxia, in order to change the IMA and ferroxidase activity.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress parameters in patients with ascending aortic dilatation

Erdoğan¹,

Polat²,

Çelik³

et al. 2020

Turk J Med Sci

View full text Add to dashboard Cite

Background/aim: This study aimed to determine plasma thiol, disulphide, and serum ischemia-modified albumin (IMA) levels and ferroxidase activity in patients with ascending aorta dilatation (AAD) in comparison to those without AAD and to evaluate the predictive value of these oxidative stress parameters for AAD. Materials and methods: This study was designed as a cross-sectional study of 184 patients who applied to our cardiology clinic. Our study population consisted of patients with AAD (n = 85) and without AAD (n = 99). A spectrophotometric method was used to determine plasma thiol, disulphide, and serum IMA levels and ferroxidase activity. Results: The native thiol and the total thiol levels were significantly higher in the control group than the AAD group (P < 0.001), whereas the disulphide and IMA levels and the ferroxidase activity were similar between the groups. The native thiol and the total thiol levels were inversely and significantly correlated with ascending aortic diameter (r =-0.38, P < 0.001; r =-0.39, P < 0.001; respectively). The left ventricle mass and the total thiol levels were independent predictors of ascending aortic diameter (β= 0.223, P = 0.02; β=-0.340, P < 0.001; respectively). Conclusion: Among oxidative stress parameters including thiols, disulphide, IMA, and ferroxidase activity, only the lower total thiol levels appear to confer a high risk for AAD development. Along with the proven diagnostic imaging methods, thiol levels may be helpful to diagnose and stratify patients with AAD.

show abstract

The diagnostic value of ischemia-modified albumin in the diagnosis of aortic pathology

Cited by 8 publications

References 26 publications

Ischemia-Modified Albumin, a Novel Predictive Marker of In-Hospital Mortality in Acute Aortic Dissection Patients

Ischemia-Modified Albumin, a Novel Predictive Marker of In-Hospital Mortality in Acute Aortic Dissection Patients

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Oxidative stress parameters in patients with ascending aortic dilatation

Contact Info

Product

Resources

About