The diagnostic value of hepcidin to predict the presence and severity of appendicitis in children

Kaiser, Margarita; Schroeckenfuchs, Magdalena; Castellani, Christoph; Warncke, Gert; Till, Holger; Singer, Georg

doi:10.1016/j.jss.2017.10.021

Cited by 9 publications

(10 citation statements)

References 33 publications

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“…Kim et al [ 38 ] evaluated the predictive values of delta neutrophil index (DNI) and myeloperoxidase index (MPXI) in 105 children with AA and found that the complicated rate was 27.6% (29/105) and the CRP had the maximum value of AUROC (0.840) when cutoff was 40 mg/L. Being consistent with the present study, Kaiser et al [ 7 ] also demonstrated that a combination of different inflammation markers may associate with higher AUROC value to predict complicated appendicitis.…”

Section: Discussionsupporting

confidence: 88%

“…The AUROC values of leukocytes and CRP were 0.84 and 0.7, respectively. In another study, Kaiser et al [ 7 ] recruited 25 NASP children who improved under conservative treatment and did not require surgical intervention and served as CG. The specific causes of NSAP were gastroenteritis (18, 72%), constipation (4, 16%), and abdominal cramps based on food intolerance (3, 12%).…”

Section: Discussionmentioning

confidence: 99%

“…Studies on the diagnostic value of WBC and CRP for diagnosing appendicitis in children have reported contradictory results [ 4 , 5 ]. It has been demonstrated that novel inflammatory biomarkers, such as calprotectin, lactoferrin, high-mobility group protein B1 (HMGB1), and hepcidin, appear to be promising for the diagnosis of suspected appendicitis [ 6 , 7 ]. However, further exploration of these markers, as well as potential others, needs to be conducted [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings

Chen

Zhu

et al. 2020

Journal of Immunology Research

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Background. Several efforts have been made to find out a valuable marker to assist the diagnosis and differentiation of gangrenous/perforated appendicitis. We aimed to determine the diagnostic capacity of soluble B7H3 (sB7H3) in acute appendicitis (AA) and its accuracy as a predictor of the severity of appendicitis. Methods. 182 children were allocated into four groups as follows: control group (CG, 90), simple appendicitis (SA, 12), purulent appendicitis (PA, 49), and gangrenous appendicitis (GA, 31). Prior to appendectomy, blood was collected and sent for analysis of routine examination and cytokines (sB7H3 and TNF-α). We compared values of all measured parameters according to histological findings. Furthermore, we assigned AA patients into the nonperforated appendicitis group and the perforated appendicitis group. The diagnostic effects of significant markers were assessed by ROC curves. Results. Only the levels of CRP, FIB, and sB7H3 had a remarkable rising trend in AA-based groups, while differences in the levels of CRP and FIB between simple appendicitis and purulent appendicitis were not statistically significant. In addition, sB7H3 was found as the only marker in children with AA, which was markedly associated with the degree of histological findings of the appendix. Furthermore, sB7H3 had a high diagnostic value in predicting AA and complex appendicitis (PA+GA) in children. However, the diagnostic performance of sB7H3 for distinguishing PA from GA was not remarkable. Additionally, only the levels of CRP and sB7H3 were statistically different between the nonperforated appendicitis group and the perforated appendicitis group. The diagnostic performance of CRP and sB7H3 could not merely predict perforation of AA in children; however, the diagnostic performance was improved after combination. Conclusions. sB7H3 could be used as a valuable marker to predict the presence of AA and complex AA in children. However, the diagnostic value of sB7H3 to predict gangrenous/perforated appendicitis was not found to be remarkable. The combination of sB7H3 and CRP might improve the prediction of perforated appendicitis.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings

Chen

Zhu

et al. 2020

Journal of Immunology Research

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“…At present, the preoperative assessment of using stress response indicators for CA were more confined to children with acute appendicitis, [12,30] but has been less reported in adults. The subject regards postoperative pathology as the standard.…”

Section: Discussionmentioning

confidence: 99%

“…Its sensitivity and specificity were similar to those reported in literature (66.67% and 51.06%, respectively). In some studies, [30,31] the association of WBC counts with CRP alone did not improve diagnostic accuracy (AUC = 0.715). However, in the present study, the above indexes were combined with some clinical manifestations of patients, and the diagnosis of CA was significantly improved.…”

Section: Discussionmentioning

confidence: 99%

Preoperative assessment of complicated appendicitis through stress reaction and clinical manifestations

Kang¹,

Li²,

Zheng³

et al. 2019

Medicine

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This study assessed the severity of the disease through the preoperative clinical manifestations and inflammatory reaction indicators of acute appendicitis, and established a score table to predict complicated appendicitis (CA). The clinical data of 238 patients with acute appendicitis in our hospital were retrospectively analyzed, which included 18 patients with acute simple appendicitis (7.6%), 170 patients with acute purulent appendicitis (72.0%), and 48 patients with acute gangrene and perforation (20.3%). The clinical manifestations and inflammatory reaction indicators were analyzed by univariate logistic regression. Multivariate logistic regression analysis was performed to screen out the independent risk factors of CA. The β coefficients of independent risk factors entering the multivariate model were assigned by rounding, and the total score was the sum of values of all factors. Finally, verification and analysis were performed for the predictive model, and the operating characteristic curve (ROC) curve was drawn. Then, the area under the curve (AUC) was compared with the THRIVE scale, and the Hosmer–Lemeshow method was used to evaluate whether the model fitted well. The multivariate logistic regression analysis of independent risk factors was performed, and the values were rounded to the variable assignment based on the β coefficient values. The plotted ROC and AUC was calculated as 0.857 ( P < .001). Using the Hosmer–Lemeshow method, the X 2 -value was 12.430, suggesting that the prediction model fitted well. The scoring system can quickly determine whether this is a CA, allowing for an earlier and correct diagnosis and treatment. Furthermore, the scoring system was convenient, economical, and affordable. Moreover, it is easy to popularized and promote.

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Diagnostic Performance of Total Platelet Count, Platelet-to-Lymphocyte Ratio, and Lymphocyte-to-Monocyte Ratio for Overall and Complicated Pediatric Acute Appendicitis: A Systematic Review and Meta-Analysis

Montero

Riveros

Martín‐Calvo

2023

Surgical Infections

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The diagnostic value of hepcidin to predict the presence and severity of appendicitis in children

Cited by 9 publications

References 33 publications

sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings

sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings

Preoperative assessment of complicated appendicitis through stress reaction and clinical manifestations

Diagnostic Performance of Total Platelet Count, Platelet-to-Lymphocyte Ratio, and Lymphocyte-to-Monocyte Ratio for Overall and Complicated Pediatric Acute Appendicitis: A Systematic Review and Meta-Analysis

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