The diagnostic value of diffusion-weighted magnetic resonance imaging in characterization of musculoskeletal soft tissue tumors

Romeih, Marwa; Raafat, Tarek; Khalaf, Mohamed; Sallam, Kareem

doi:10.1016/j.ejrnm.2018.01.014

Cited by 6 publications

(12 citation statements)

References 19 publications

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“…The benign STTs recorded in 40.5%, while malignant tumors were found in 59.5% of patients. That is agreement with the results of Romeih et al (benign 44% vs. malignant 56%), but disagree with Chung et al, as 102 lesions were malignant and 164 were benign, and Lee et al, as 66 lesions were non-malignant and 29 were malignant [12,13,14].…”

Section: рис 2 схемаsupporting

confidence: 79%

“…site of STTs in this study. In Romeih et al study reported 30 patients had lower limb soft tissue lesions, while other lesions were detected in the upper limbs and trunk [12].…”

Section: рис 2 схемаmentioning

confidence: 95%

“…DW-MRI with ADC mapping is a rapidly, valuable, non-invasive, non-contrast tool for reliably differentiating between benign and malignant STTs [12].…”

Section: рис 2 схемаmentioning

confidence: 99%

“…they found six cases of synovial sarcoma (the second-most common malignant lesions) a mean ADC value of 0.77 ± 0.21×10−3 mm2/s. also they included four cases of liposarcoma, and two cases each of undifferentiated round-cell sarcoma, Ewing's sarcoma and fibrosarcoma (ADC values of 0.53, 0.80, and 0.70×10−3 mm2/s, respectively) [12]. Also, they encountered four cases of malignant myxoid tumours (myxoid liposarcoma) with high ADC values of 2.30 ± 0.28×10−3 mm2/s [12].…”

Section: рис 2 схемаmentioning

confidence: 99%

“…also they included four cases of liposarcoma, and two cases each of undifferentiated round-cell sarcoma, Ewing's sarcoma and fibrosarcoma (ADC values of 0.53, 0.80, and 0.70×10−3 mm2/s, respectively) [12]. Also, they encountered four cases of malignant myxoid tumours (myxoid liposarcoma) with high ADC values of 2.30 ± 0.28×10−3 mm2/s [12]. They observed the highest ADC values in giant-cell tumours (2.35×10−3 mm2/s), haemangiomas (2.10×10−3 mm2/s), and schwannomas (1.9×10−3 mm2/s) [12].…”

Section: рис 2 схемаmentioning

confidence: 99%

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The Role of Apparent Diffusion Coefficient Value in Differentiating Benign From Malignant Soft Tissue Masses

Kareem¹,

Kadhim²,

Al-Naqqash³

2021

Rejr

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ackground. Soft tissue masses are frequently referred for imaging assessment. Magnetic resonance imaging (MRI) is the technique of choice for detection of these masses and local staging of the malignant one. Purpose. The study is aimed to measure the apparent diffusion coefficient (ADC) values of different soft tissue masses and determine the cut-off value that can be helpful in differentiating between the benign and malignant histological types.Materials and methods. A prospective study was conducted in the Radiology Department of the Oncology Teaching Hospital. A total of 37 cases enrolled during the period from 12th July 2019 to 20th February 2020. Diffusion weighted images (DWI) were performed for all cases. The mean ADC value for the enhancing component of each mass was measured on the generated ADC map done at high b-value of 800 sec/mm2.Results. The benign soft tissue masses were recorded in 15 (40.5%), while malignant masses found in 22 (59.5%) of patients. The greatest ADC values (mean±SD) measured for the benign masses was (1.97 x10-3 mm2/s ±0.39) for hemangiomas. While the greatest ADC value results for the malignant masses was for myxoid liposarcoma (2.11 x10-3 mm2/s ±0.45). The lowest ADC values were observed in hematological tumors. In a selected group of masses which their enhancing componenet expressed low signal or intermediate hyperintense signal in T2-WI (n=26), the mean ADC value for the malignant masses (n=18) was lower than the mean ADC value of benign (n=8) (0.863±0.28 vs. 1.675±0.39), with statistically significant association (P-value=0.002) and the ADC cut-off value of 1.42 x10-3 mm2/s gives a high sensitivity of 94.44%, a high specificity of 87.5%, and accuracy of 92.31% for differentiating malignant from benign masses which was statistically significant (P-value <0.000).Conclusions. In a selected group of soft tissue masses which their enhancing componenet express low or intermediate hyperintense signal in T2-WI, the mean ADC value was lower in malignant soft tissue masses than that in benign masses with a cut off value of 1.42 x10-3 mm2/s gives a high sensitivity and a high specificity.

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Section: рис 2 схемаsupporting

confidence: 79%

“…site of STTs in this study. In Romeih et al study reported 30 patients had lower limb soft tissue lesions, while other lesions were detected in the upper limbs and trunk [12].…”

Section: рис 2 схемаmentioning

confidence: 95%

“…DW-MRI with ADC mapping is a rapidly, valuable, non-invasive, non-contrast tool for reliably differentiating between benign and malignant STTs [12].…”

Section: рис 2 схемаmentioning

confidence: 99%

Section: рис 2 схемаmentioning

confidence: 99%

Section: рис 2 схемаmentioning

confidence: 99%

See 3 more Smart Citations

The Role of Apparent Diffusion Coefficient Value in Differentiating Benign From Malignant Soft Tissue Masses

Kareem¹,

Kadhim²,

Al-Naqqash³

2021

Rejr

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Imaging of head and neck lipoblastoma: case report and systematic review

et al. 2020

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Role of diffusion-weighted MRI in evaluation of pediatric musculoskeletal soft tissue masses

EL-Adalany

Eid

Othman³

et al. 2021

Egypt J Radiol Nucl Med

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Background In pediatric patients, soft tissue masses encompass a wide heterogeneous group of benign and malignant lesions. MRI is a powerful diagnostic tool in the workup of soft tissue tumors in children, and it helps in characterization of lesion and evaluation of the extent of the lesion. However, conventional MRI techniques are not specific in differentiating benign from malignant lesions. So to improve characterization of tumors, DWI was added to MRI techniques as it increases sensitivity and specificity by detecting the micro-diffusion changes of water into intra- and extracellular spaces. The aim of this work was to highlight the diagnostic value of DWI in detection and characterization of different musculoskeletal soft tissue masses in pediatrics. Results There was a statistically significant difference regarding the mean ADC value of benign and malignant masses (P value = 0.001*). The mean ADC value for all benign masses (n = 41) was 1.495 ± 0.55 SD × 10–3 mm2/s, while the mean ADC value for all malignant masses (n = 21) was 0.449 ± 0.27 SD × 10–3 mm2/s. The cutoff ADC value between benign and malignant masses was 0.88 × 10–3 mm2/s. This cutoff ADC value has sensitivity of 100.0%, specificity of 92.3%, PPV of 66.7%, NPV of 100.0% and diagnostic accuracy of 93.3%. Conclusion In pediatric patients, DWI is an innovative valuable noninvasive imaging technique for characterization of musculoskeletal soft tissue masses and discrimination between benign and malignant masses.

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The diagnostic value of diffusion-weighted magnetic resonance imaging in characterization of musculoskeletal soft tissue tumors

Cited by 6 publications

References 19 publications

The Role of Apparent Diffusion Coefficient Value in Differentiating Benign From Malignant Soft Tissue Masses

The Role of Apparent Diffusion Coefficient Value in Differentiating Benign From Malignant Soft Tissue Masses

Imaging of head and neck lipoblastoma: case report and systematic review

Role of diffusion-weighted MRI in evaluation of pediatric musculoskeletal soft tissue masses

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