The diagnostic value of CRP and ADA biomarkers for differentiation of exudative pleural effusion

Abstract

Background:The aim of the present study was to investigate the roles biomarkers C-reactive protein (CRP) and adenosine deaminase (ADA) in the differentiation of exudative pleural effusion and tuberculosis from nontuberculosis pleural effusion. Methods: The present study enrolled 150 patients with pleural effusion that were admitted to hospital between 2012-2015. From the patients were obtained pleural fluid and serum which were administrated to test analyses within 24 hours. ADA and CRP levels were compared between the groups of exudative pleural effusion. Based on Light's criteria, biochemical, cytological etc. analyses were established the pleural effusion as exudative and the etiology of the effusion, 60 malign, 48 tuberculosis, 42 parapneumonic. Results: ADA and CRP levels differ significantly between the different groups of exudative pleural effusion but ADA ratio, pleural fluid/serum, didn't contribute in this difference. As a better test for the difference of tuberculosis from non-tuberculosis was evaluated, ADA level in pleural fluid. Conclusions: ADA and CRP are considerable biomarker for the differences in exudative pleural effusion groups and for the difference of tuberculosis from non-tuberculosis pleural effusion. It is recommended that that other markers need to be taken into consideration to assist the results.

An Evaluation of Levels of C - reactive protein in Serum and Pleural Fluid of Pleural Effusion of Different Etiology

“…Once the possible exudative pleural effusion is set up it is needed to determine the etiology of the effusion. The common causes for an exudative pleural effusion are malign, parapneumonic and tuberculosis (Hakani and Mitre, 2016).…”

“…Adenosine deaminase (ADA) is an enzyme associated with T lymphocyte activity and is produced from all the cells of human body but its level are higher in lymphocytes.6 ADA plays an important role in the differentiation and maturation of the lymphoid system. C-reactive protein (CRP) is a protein of acute phase inflammation that is produced by liver and is present in the body before the antibodies (Hakani and Mitre, 2016).…”