The diagnostic value of circulating microRNAs in heart failure (Review)

Huang, Yao‑Meng; Li, Weiwei; Wu, Jun; Han, Mei; Li, Binghui

doi:10.3892/etm.2019.7177

Cited by 26 publications

(32 citation statements)

References 123 publications

(73 reference statements)

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“…For example, during myocardial ischemia, the level of miR-21 decreases sharply, and supplementing its expression reduces the size of the attack and delays the development of HF [51]. It was also proposed that miR-21 could be an indicator of late age in ischemic heart failure [52]. Numerous studies indicate that both the heart and circulatory miR-21 correlate with the degree of cardiac fibrosis [53].…”

Section: Resultsmentioning

confidence: 99%

Meta-Analysis of the Potential Role of miRNA-21 in Cardiovascular System Function Monitoring

Krzywińska

Bracha

Jeannière

et al. 2020

BioMed Research International

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MicroRNAs (miRNAs) are short and noncoding RNA fragments that bind to the messenger RNA. They have different roles in many physiological or pathological processes. MicroRNA-21, one of the first miRNAs discovered, is encoded by the MIR21 gene and is located on the chromosomal positive strand 17q23.2. MicroRNA-21 is transcribed by polymerase II and has its own promoter sequence, although it is in an intron. It is intra-and extracellular and can be found in many body fluids, alone or combined with another molecule. It regulates many signalling pathways and therefore plays an important role in the cardiovascular system. Indeed, it is involved in the differentiation and migration of endothelial cells and angiogenesis. It contributes to the reconstruction of a myocardial infarction, and it can also act as a cellular connector or as an antagonist to cardiac cell apoptosis. By playing all these roles, it can be interesting to use it as a biomarker, especially for cardiovascular diseases.

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Section: Resultsmentioning

confidence: 99%

Meta-Analysis of the Potential Role of miRNA-21 in Cardiovascular System Function Monitoring

Krzywińska

Bracha

Jeannière

et al. 2020

BioMed Research International

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“…Our bioinformatics analysis found ACE2 was significantly down-regulated in SARS-CoV-2 infected CMs, which was consistent with the prior reports of examining SARS-CoV-2 infected myocardium [ 50 ]. SARS-CoV-2 mediated myocardial apoptosis, cardiogenic shock, myocardial ischemia and inflammatory injury were related to the down-regulation of ACE2 in the myocardium [ [51] , [52] ]. The spike protein of SARS-CoV-2 might bind to TLR4 to trigger transmembrane stimulation [ [53] , [54] ].…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology and RNA-sequencing reveal the molecular mechanism of Xuebijing injection on COVID-19-induced cardiac dysfunction

Zhang

Zhu

et al. 2021

Computers in Biology and Medicine

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Background Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Up to 20%–30% of patients hospitalized with COVID-19 have evidence of cardiac dysfunction. Xuebijing injection is a compound injection containing five traditional Chinese medicine ingredients, which can protect cells from SARS-CoV-2-induced cell death and improve cardiac function. However, the specific protective mechanism of Xuebijing injection on COVID-19-induced cardiac dysfunction remains unclear. Methods The therapeutic effect of Xuebijing injection on COVID-19 was validated by the TCM Anti COVID-19 (TCMATCOV) platform. RNA-sequencing (RNA-seq) data from GSE150392 was used to find differentially expressed genes (DEGs) from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) infected with SARS-CoV-2. Data from GSE151879 was used to verify the expression of Angiotensin I Converting Enzyme 2 (ACE2) and central hub genes in both human embryonic-stem-cell-derived cardiomyocytes (hESC-CMs) and adult human CMs with SARS-CoV-2 infection. Results A total of 97 proteins were identified as the therapeutic targets of Xuebijing injection for COVID-19. There were 22 DEGs in SARS-CoV-2 infected hiPSC-CMs overlapped with the 97 therapeutic targets, which might be the therapeutic targets of Xuebijing injection on COVID-19-induced cardiac dysfunction. Based on the bioinformatics analysis, 7 genes (CCL2, CXCL8, FOS, IFNB1, IL-1A, IL-1B, SERPINE1) were identified as central hub genes and enriched in pathways including cytokines, inflammation, cell senescence and oxidative stress. ACE2, the receptor of SARS-CoV-2, and the 7 central hub genes were differentially expressed in at least two kinds of SARS-CoV-2 infected CMs. Besides, FOS and quercetin exhibited the tightest binding by molecular docking analysis. Conclusion Our study indicated the underlying protective effect of Xuebijing injection on COVID-19, especially on COVID19-induced cardiac dysfunction, which provided the theoretical basis for exploring the potential protective mechanism of Xuebijing injection on COVID19-induced cardiac dysfunction.

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“…Chatterjee et al reported a novel function of miR-147b in protecting barrier function in human vascular endothelial cells, which affects CVDs, and expression of microR-147 in CAD patients was reported less compared to the controls [ 113 ]. Yao-Meng et al [ 109 ] reported lower expression miR-147 in patients with dilated cardiomyopathy (DCM) compared with control subjects, suggesting its role as a potential diagnostic biomarker [ 114 ]. Mingxia Gu et al have shown that miR-147b inhibits viability and promotes cell apoptosis, which has a role in the pathogenesis of heart failure [ 115 ].…”

Section: Role Of Micror-147b In Cadmentioning

confidence: 99%

Role of Selected miRNAs as Diagnostic and Prognostic Biomarkers in Cardiovascular Diseases, Including Coronary Artery Disease, Myocardial Infarction and Atherosclerosis

Mir

Elfaki

Khullar³

et al. 2021

JCDD

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Cardiovascular diseases are the leading cause of death worldwide in different cohorts. It is well known that miRNAs have a crucial role in regulating the development of cardiovascular physiology, thus impacting the pathophysiology of heart diseases. MiRNAs also have been reported to be associated with cardiac reactions, leading to myocardial infarction (MCI) and ultimately heart failure (HF). To prevent these heart diseases, proper and timely diagnosis of cardiac dysfunction is pivotal. Though there are many symptoms associated with an irregular heart condition and though there are some biomarkers available that may indicate heart disease, authentic, specific and sensitive markers are the need of the hour. In recent times, miRNAs have proven to be promising candidates in this regard. They are potent biomarkers as they can be easily detected in body fluids (blood, urine, etc.) due to their remarkable stability and presence in apoptotic bodies and exosomes. Existing studies suggest the role of miRNAs as valuable biomarkers. A single biomarker may be insufficient to diagnose coronary artery disease (CAD) or acute myocardial infarction (AMI); thus, a combination of different miRNAs may prove fruitful. Therefore, this review aims to highlight the role of circulating miRNA as diagnostic and prognostic biomarkers in cardiovascular diseases such as coronary artery disease (CAD), myocardial infarction (MI) and atherosclerosis.

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The diagnostic value of circulating microRNAs in heart failure (Review)

Cited by 26 publications

References 123 publications

Meta-Analysis of the Potential Role of miRNA-21 in Cardiovascular System Function Monitoring

Meta-Analysis of the Potential Role of miRNA-21 in Cardiovascular System Function Monitoring

Network pharmacology and RNA-sequencing reveal the molecular mechanism of Xuebijing injection on COVID-19-induced cardiac dysfunction

Role of Selected miRNAs as Diagnostic and Prognostic Biomarkers in Cardiovascular Diseases, Including Coronary Artery Disease, Myocardial Infarction and Atherosclerosis

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