1949
DOI: 10.1080/00034983.1949.11685414
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The Diagnostic Value of Bone-Marrow Biopsy in Malaria Caused byPlasmodium Falciparum

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Cited by 7 publications
(8 citation statements)
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“…Indeed, recent work with P. vivax in splenectomized rhesus macaques demonstrated those spaces of bone marrow as the dominant compartment of that infection [7]. Plasmodium falciparum has also been shown to interact with bone marrow; employing it as a site of maturation and for evasion of the host immune response [8][9][10][11][12][13]. For initiation of active P. falciparum merozoites entry, the erythrocyte binding-like (EBL) and reticulocyte binding-like (Rh) protein families are responsible for binding to specific erythrocyte receptors [14].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Indeed, recent work with P. vivax in splenectomized rhesus macaques demonstrated those spaces of bone marrow as the dominant compartment of that infection [7]. Plasmodium falciparum has also been shown to interact with bone marrow; employing it as a site of maturation and for evasion of the host immune response [8][9][10][11][12][13]. For initiation of active P. falciparum merozoites entry, the erythrocyte binding-like (EBL) and reticulocyte binding-like (Rh) protein families are responsible for binding to specific erythrocyte receptors [14].…”
Section: Introductionmentioning
confidence: 99%
“…The presence of malarial parasites in the bone marrow was first reported in 1894 in malarial fevers occurring during summer and autumn [20]. Later, bone marrow aspiration was described as an accessory and useful tool in the diagnosis of malaria especially in cases where strong suspicion of malaria could not be confirmed on routine peripheral smears [9][10][11]. Peripheral smear examination under light microscopy remains the gold standard of malaria diagnosis and consistently negative findings in a patient are considered definitive.…”
Section: Introductionmentioning
confidence: 99%
“…The hemogram blood test results of patients with Plasmodium infection in the bone marrow concur with the consensus regarding the initiation of bone marrow puncture for the diagnosis of malaria: For patients with atypical manifestations, especially those who exhibit pancytopenia and febrile neutropenia [37], more invasive screening test, such as bone marrow puncture, could be performed to exclude malaria infection [38][39]. However, bone marrow puncture should be avoided for patients with acute attack of malaria, who exhibit clinical symptoms and more pronounced pancytopenia in the peripheral blood, due to the concern of unjusti ed procedure [40,5]. In summary, the appropriate candidates for bone marrow puncture of Plasmodium testing are those with a traveling history to malaria-endemic areas, exhibition of fever, anemia, thrombocytopenia and splenomegaly, undetected Plasmodium in the peripheral blood, suspicious antigen test results, as well as the exclusion of other microbial infections, such as bacteria and mycoplasma.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed recent work with P. vivax in splenectomised rhesus macaques demonstrated those spaces of bone marrow as the dominant compartment of that infection [6]. Plasmodium falciparum has also been shown to interact with bone marrow; employing it as a site of maturation and for evasion of the host immune response [7][8][9][10][11][12]. The anaemia that often develops with acute malaria involves bone marrow suppression and ineffective erythropoiesis [13][14][15][16].…”
Section: Introductionmentioning
confidence: 99%
“…Malarial parasites were rst demonstrated in the bone marrow on autopsies of lethal malaria cases in 1892, not long after the discovery of the malarial parasite [3]. Later, bone marrow aspiration was described as an accessory and useful tool in the diagnosis of malaria especially in cases where strong suspicion of malaria could not be con rmed on routine peripheral smears [8][9][10]. Peripheral smear examination under light microscopy remains the gold standard of malaria diagnosis and consistently negative ndings in a patient are considered de nitive.…”
Section: Introductionmentioning
confidence: 99%