The diagnostic value of anti-endomysium and antigliadin antibodies in untreated celiacs; Disappointing in clinical practice

Rostami, Kamran; Kerckhaert, J.; Tiemessen, R.; Blomberg, Bme von; Meijer, Jwr; Mulder, Cjj

doi:10.1016/s0016-5085(98)81663-6

Cited by 7 publications

(8 citation statements)

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“…Five subjects were found to have low serum iron (, 50 ìg/dl) and low serum ferritin (, 50 ìg/dl), two of these subjects (one male, one female) had mild anaemia (haemoglobin, 12.6 g/dl and 12.8 g/dl, respectively); the other seven seropositive subjects were found to have normal laboratory results. All subjects with positive serology (both AGA and EMA) were found to have small bowel biopsies compatible with gluten sensitive enteropathy [4,12,13]. Three of 12 had Marsh I, 4/12 Marsh II and 5/12 showed Marsh IIIa lesions.…”

Section: Resultsmentioning

confidence: 99%

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High prevalence of coeliac disease in apparently healthy Iranian blood donors

Shahbazkhani

Malekzadeh

Sotoudeh

et al. 2003

European Journal of Gastroenterology & Hepatology

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Section: Resultsmentioning

confidence: 99%

“…All biopsy specimens were reviewed by two investigators according to the modified Marsh UEGW criteria [3,12,13]. Marsh I comprises normal mucosal architecture in which the villous epithelium is markedly infiltrated by lymphocytes with lymphocytosis scores of more than 30 per 100 enterocytes.…”

Section: Methodsmentioning

confidence: 99%

High prevalence of coeliac disease in apparently healthy Iranian blood donors

Shahbazkhani

Malekzadeh

Sotoudeh

et al. 2003

European Journal of Gastroenterology & Hepatology

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“…These samples were immediately and completely submerged in neutral buffered formalin and processed according to standard procedures. All biopsy specimens were reviewed by two pathologists experienced in coeliac disease pathology and graded according to the modified Marsh criteria 7–9 …”

Section: Methodsmentioning

confidence: 99%

Coeliac disease presenting with symptoms of irritable bowel syndrome

Shahbazkhani

Forootan

Merat

et al. 2003

Aliment Pharmacol Ther

101

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Summary Background : Coeliac disease may easily mimic symptoms which are parts of the criteria used for diagnosing irritable bowel syndrome. Aim : To find the frequency of coeliac disease among patients diagnosed as irritable bowel syndrome. Methods : During a period of one year, irritable bowel syndrome patients referred to a university clinic in Tehran were studied. For each patient, an asymptomatic sibling was enrolled as control. Serological tests for coeliac disease were performed in all patients and controls. If positive, duodenal biopsy was performed to confirm the diagnosis. Patients subsequently diagnosed as coeliac disease were placed on a gluten free diet and re‐evaluated after 6 months. Results : One hundred and five cases of irritable bowel syndrome and 105 controls were enrolled. Coeliac disease was diagnosed in 12 of the irritable bowel syndrome patients and none of the controls. Eleven coeliac disease patients adhered to a gluten free diet. After 6 months, all 11 patients had significant improvement in symptoms and three were totally asymptomatic. Six allowed repeated endoscopy after 6 months of gluten free diet, of which five showed improvement in histological findings. Conclusions : Coeliac disease is a common finding among patients labelled as irritable bowel syndrome. In this sub‐group, a gluten free diet may lead to a significant improvement in symptoms. Routine testing for coeliac disease may be indicated in all patients being evaluated for irritable bowel syndrome.

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“…25 As the EMA test relies on indirect immunofluorescence, it is susceptible to inter-observer variability and interference from other antibody staining. 26 Furthermore, the sensitivity may be lower in patients with lesser degrees of villous atrophy or lymphocytic duodenosis lesions. 27 Given that such patients may have fewer clinical features of the disease, the true sensitivity of the test may be even lower.…”

Section: Serological Diagnosis Of Coeliac Diseasementioning

confidence: 99%