The diagnostic value of [18F]FDG PET for the detection of chronic osteomyelitis and implant-associated infection

Abstract

[(18)F]FDG PET is able to identify with high sensitivity the presence of osteomyelitis in orthopaedic surgery patients with nonspecific clinical symptoms of infection.

Accuracy of diagnostic imaging modalities for peripheral post-traumatic osteomyelitis – a systematic review of the recent literature

“…This resulted in four more exclusions [50, 51, 56, 57]. For this process, additional information was obtained by email from two corresponding authors [52, 55]. Finally, 10 studies [21, 45–49, 52–55] remained for inclusion in this systematic review.…”

“…For this process, additional information was obtained by email from two corresponding authors [52, 55]. Finally, 10 studies [21, 45–49, 52–55] remained for inclusion in this systematic review. The inclusion process is summarized in Fig.…”

“…Six studies addressed the value of FDG-PET in the diagnostic process for PTO [46, 48, 52–55], 5 studies addressed WBC or AGA scintigraphy [21, 45, 47, 49, 52], 2 studies addressed MRI [46, 49], 3 studies addressed bone scintigraphy [45, 49, 52], and one study focused on CT [46]. A schematic overview of the included studies is presented in Table 4.…”

“…Gold standard: microbiology (n = 20), clinical FU 6 months.Pain at motion or rest for at least 6 weeks, interval between last surgical intervention and FDG-PET scan 6 weeks – 14 months.Shemesh et al [54]201510 18 F -FDG-PET, 296–555 MBq.YesRetrospective. Gold standard: microbiology (n = 9, five cultures minimum); otherwise, overall clinical assessment with minimum of 1 year FU.Time from initial surgery to PET/CT 2 months – 20 years.Wenter et al [55]201684 18 F-FDG-PET, weight adapted dose (mean 252 +/- 76 MBq). 131 patients underwent PET/CT with mostly a full dose CT (n = 130) with iv contrast (n = 106).NoRetrospective.…”

“…Six studies [46, 48, 52–55] were included addressing the value of FDG-PET in diagnosing PTO, three combined with CT [48, 54, 55]. Goebel et al [46] prospectively investigated the diagnostic value of FDG-PET in 48 patients with peripheral PTO and compared this with CT (n = 22) and MRI (n = 18).…”