The diagnostic utility of scintigraphy in esophageal burn: a rat model

Çiftçi, Öznur Dilek; Gül, Serdar; Açıksarı, Kurtuluş; Maman, Adem; Çavuşoğlu, Türker; Bademci, Refik; Taşkıran, Dilek; Erbaş, Oytun

doi:10.1016/j.jss.2015.09.006

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…Therefore, it has been considered beneficial in the diagnosis of acute phase myocardial infarction and quantification of the infarct size in the clinical setting [30][31][32][33]. Previous studies have also suggested that the degree of radiopharmaceutical accumulation such as 99m Tclabeled phosphonates, and 99m Tc PYP is a good index of the severity of tissue damage [34][35][36][37][38]. In the present study, we observed increased 99m Tc PYP radiopharmaceutical uptake on heart area in the DOXinduced cardiotoxicity rat model.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective effect of vitamin D and melatonin on doxorubicin-induced cardiotoxicity in rat model: an electrocardiographic, scintigraphic and biochemical study

Gül

Aygün

2019

The European Research Journal

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Objectives: Doxorubicin (DOX) is an antineoplastic drug that is widely used in chemotherapy but its cardiotoxicity is the most important side effect that limits the clinical use of this drug. We investigated DOX treatment and the effects of vitamin D and melatonin on heart by electrocardiography, scintigraphic and biochemical methods. Methods: In this study, forty-nine adult male Wistar albino rats (220 ± 15 g) were randomly divided into seven groups (n = 7 each), namely control (CON, n = 7), doxorubicin (DOX, n = 7), melatonin (MEL, n = 7), vitamin D (Vit D, n = 7), doxorubicin plus melatonin (DOX+MEL, n = 7), doxorubicin plus vitamin D (DOX+Vit D, n = 7), and doxorubicin plus melatonin and vitamin D (DOX+MEL+Vit D, n = 7) groups. Cardiotoxicity was induced by intraperitoneal injection (i.p.) of DOX (18 mg/kg, i.p.) on the 15 th , 16 th and 17 th days. Rats receiving vitamin D and melatonin treatment in the DOX-induced cardiotoxicity group received vitamin D (60,000 IU/kg, i.p.) were administered in a single dose and melatonin (40 mg/kg/day, i.p.) for 17 days and were injected with (18 mg/kg, i.p.) on doxorubicin 15 th , 16 th , and 17 th days. On the 18 th day electrocardiography (ECG), 99m Technetium pyrophosphate scintigraphy and biochemical parameters were assessed. Results: DOX caused changes in the ECG pattern, a significant decrease in heartbeat (p < 0.01), P wave (p < 0.001) and QRS complex durations (p < 0.001), R wave amplitude (p < 0.001); elevation in ST-segment (p < 0.001) and decrease in QT interval (p < 0,001), and R-R interval durations (p < 0.001); increase in the serum levels of cardiac injury markers (CK, BUN, cardiac troponin T), (p < 0.01), and increased 99m Technetium pyrophosphate uptake (p < 0.001) as compared to the CON group. MEL, Vit D and MEL+Vit D administration showed a same protective effect against DOX-induced altered ECG pattern. Pre-treatment with MEL, Vit D and MEL+Vit D significantly protected the heart from the toxic effect of DOX, by decreasing the levels of of cardiac injury markers (CK, BUN, cardiac troponin T) (p < 0.001) and decreased the elevated level of 99m Technetium pyrophosphate uptake (p < 0.001). Conclusion: Vitamin D and melatonin treatment prevented all the parameters of DOX-induced cardiotoxicity in rats.

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Section: Discussionmentioning

confidence: 99%

Cardioprotective effect of vitamin D and melatonin on doxorubicin-induced cardiotoxicity in rat model: an electrocardiographic, scintigraphic and biochemical study

Gül

Aygün

2019

The European Research Journal

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“…На сьому добу в щурів у групі G3 ІС достовірно збільшується в 3,5 рази порівняно до контрольної групи G1, а у щурів групи G4 цей показник зростав тільки в 1,7 разів. Таке швидке звуження просвіту стравоходу обумовлюється гострою фазою запалення та набряком [5].…”

Section: отримання екстракту стручків квасолі звичайноїunclassified

“…Актуальність проблеми зумовлена зростанням частоти даної патології та збільшенням кількості пацієнтів із НВК, у яких усе частіше зустрічаються важкі форми хвороби, що призводять до інвалідизації, а іноді й до летального результату [4][5][6].…”

Section: метою дослідження було визначення морфологічних особливостейunclassified

Eeffect of an aquaeous extract of Phaseolus vulgaris pods on morphological properties of post-burn esophagus

Raetska

2019

BTSNUKSPPFR

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The most widespread chemical damage in children – burn of the esophagus. It occurs when accidentally swallowing substances that have in their composition alkali, acid or other caustic substances. The depth of burn depends on the concentration and time of contact of the mucous membrane with the affecting agent. As a result of penetration of alkalis and contact with the wall of the esophagus, along with necrosis, damage to the mucous membrane, submucosal and muscular membrane of the esophagus occurs. Despite a large number of drugs that have been tested in the treatment of complications caused by esophageal burns, there is little information that would indicate the high effectiveness of the previously used drugs. The analysis of literature data shows the positive influence of polyphenols of natural origin on the normalization of physiological and biochemical parameters in various pathologies. The extract of common beans (Phaseolus vulgaris pods extract (PVPE)) is an example of a rich bioactive component of the source with beneficial characteristics for humans. Therefore, the purpose of our work was to investigate the effect of the Phaseolus vulgaris pods extract on the healing of post-burns wounds. When morpho-functional characteristics of the esophagus changes in the conditions of alkaline burn of the esophagus of the 2nd degree, it was shown that at 1 day of the experiment there is a violation of the mucous membrane, which manifests itself in the destruction of the multilayered epithelium, namely, in the submucous membrane there is a significant accumulation of leukocytes, leukocytic infiltration is fixed in the partly destroyed muscle layer. At 31 days of study in a group of animals with burn of the esophagus there is a certain restoration of the integrity of the mucous membrane of the esophagus, mainly with hyperplasia; there is also a decrease in the presence of leukocytes; however, there is an enlargement of the connective tissue in the submucosal membrane, which may indicate the formation of a scar. The data of the morphological description are confirmed by the morphometric parameters of the calculation of the stenosis index. With the use of extracts of beans under chemical burns esophagus conditions, improvement of the morpho-functional status of the esophagus of rats was noted: the formed connective tissue scar does not significantly affect the stenosis index (its significance is the intermediate position); the high level of leukocyte infiltration is reduced to the control parameters, which may indicate the obvious therapeutic effect of the extract of beans pods at alkaline burns of the esophagus.

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“…In the last two decades, clinical and experimental studies have been performed assessing the value of scintigraphic evaluation and detection of caustic injury of the esophagus [57,58]. Millar et al performed a prospective clinical study to assess whether sucralfate has an affinity for the chemically injured esophagus and to assess the accuracy of radiolabeled sucralfate as an indicator of the presence and extent of esophageal injury [57].…”

Section: Scintigraphymentioning

confidence: 99%

“…They found that technetium-99m scintigraphy is an accurate diagnostic method to assess caustic esophageal injury [57]. Technetium-99m pyrophosphate scintigraphy has been used in diagnostic studies on the detection of caustic esophageal injury [58,59].…”

Section: Scintigraphymentioning

confidence: 99%

Caustic Ingestion

Temız¹

2017

Pediatric and Neonatal Surgery

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Caustic ingestion with resultant esophagitis and gastritis is still an important social and medical problem due to early and long-term complications. This injury is seen frequently as an accidental event and may also lead to psychosocial impacts, including antisocial behavior, suicide attempts, criminal incarceration, and educational delinquency. It often occurs as a result of uncontrolled and unsafe storage of materials used in household cleaning. Despite the various treatment proposals, optimal management of the patients remains controversial. The presentation of the depth and extent of injury with endoscopy plays a key role in treatment planning. In the absence of life-threatening complications, the general approach is conservative management in the acute period. The most common complications are esophageal stricture and gastric outlet obstruction. Different treatment methods such as bougienage, stent application, balloon dilation, or esophageal replacement are used in the treatment of the caustic esophageal strictures. The decision of the least invasive method for the treatment of complications will reduce the potential hazardous results.

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The diagnostic utility of scintigraphy in esophageal burn: a rat model

Cited by 7 publications

References 20 publications

Cardioprotective effect of vitamin D and melatonin on doxorubicin-induced cardiotoxicity in rat model: an electrocardiographic, scintigraphic and biochemical study

Cardioprotective effect of vitamin D and melatonin on doxorubicin-induced cardiotoxicity in rat model: an electrocardiographic, scintigraphic and biochemical study

Eeffect of an aquaeous extract of Phaseolus vulgaris pods on morphological properties of post-burn esophagus

Caustic Ingestion

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