The Diagnostic Usefulness of Serum Total Bile Acid Concentrations in the Early Phase of Acute Pancreatitis of Varied Etiologies

Maleszka, Aleksandra; Dumnicka, Paulina; Matuszyk, Aleksandra; Pędziwiatr, Michał; Mazur-Laskowska, Małgorzata; Sporek, Mateusz; Ceranowicz, Piotr; Olszanecki, Rafał; Kuźniewski, Marek; Kuśnierz-Cabała, Beata

doi:10.3390/ijms18010106

Cited by 13 publications

(18 citation statements)

References 24 publications

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“… 4 – 6 Recent studies have demonstrated that serum total bile acid, serum neutrophil gelatinase-associated lipocalin and serum soluble Fms-like tyrosine kinase 1 might play a role in prediction of severity of AP. 7 – 9 …”

Section: Introductionmentioning

confidence: 99%

Predictors of acute pancreatitis with low elevation of serum amylase

Hong¹,

Geng²,

Chen³

et al. 2017

TCRM

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Background and aimsSerum amylase is a traditional measure used to establish the diagnosis of acute pancreatitis (AP). The current study aimed to assess the predictors and clinical outcome of AP with low serum amylase.MethodsAll patients were divided into two groups, based on their serum amylase level within the first 2 days after hospital admission: group 1 (amylase ≥300 U/L) and group 2 (amylase <300 U/L). Clinical outcomes were compared between the two groups before and after 1:1 propensity score matching. Clinical and biochemical parameters were collected and evaluated as potential predictors of AP with low serum amylase.ResultsA total of 464 patients were enrolled. After propensity score matching according to age, gender, time interval before admission, hematocrit, blood urea nitrogen and creatinine, 108 matched pairs of patients were selected. There was no significant statistical difference between group 2 and group 1 with respect to severity of AP, median days of stay in hospital and death. Multivariate analysis indicated that biliary etiology (odds ratio [OR]: 0.499; 95% confidence interval [CI]: 0.265–0.942; P=0.003), low-density lipoprotein cholesterol (LDL-C) (OR: 1.009; 95% CI: 1.002–1.017; P=0.017) and triglyceride levels (OR: 1.001; 95% CI: 1.0001–1.001; P=0.015) were independently associated with development of AP along with low serum amylase.ConclusionSerum amylase level was not related to the severity of AP, median hospital stay (days) and death. Biliary etiology, LDL-C and triglyceride levels were independently associated with the development of AP with lower elevation of serum amylase.

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Section: Introductionmentioning

confidence: 99%

Predictors of acute pancreatitis with low elevation of serum amylase

Hong¹,

Geng²,

Chen³

et al. 2017

TCRM

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“…The cut-off values of 4.7 mol/L, with a diagnostic accuracy of 85%. However, circulating TBA had nothing to do with the severity of AP [15].…”

Section: Discussionmentioning

confidence: 96%

“…Dysregulation of BAs transport and impaired BAs receptor signalling may contribute to the pathogenesis of some metabolic diseases such as non-alcoholic fatty liver disease, obesity, type 2 diabetes, and atherosclerosis [14]. The circulating TBA levels are maintained within a certain range under physiological conditions, generally 2-10 μmol/L [15], but in some states of diseases, the levels of circulating TBA will exceed the threshold. An increase in circulating TBA is predominately detected in several hepatobiliary diseases.…”

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confidence: 99%

Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis

Xie

et al. 2020

Preprint

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Background: Recent studies have shown that bile acids (BAs) are closely related to metabolic and inflammatory diseases. Our study aimed to investigate whether circulating total bile acid (TBA) levels were associated with the severity of acute pancreatitis (AP).Methods: We retrospectively collected data on patients diagnosed with AP in a tertiary center from 01 January 2014 to 31 December 2016. The highest TBA value during the first 1,2,3,5,7 days after admission was determined as D1, D2, D3, D5, D7 TBAmax. Patients were divided into the high TBA (HTBA) group and the normal TBA (NTBA) group according to whether the TBAmax was ≥10μmol/L. The prognosis and complications, including death, organ failure (OF) and pancreatic necrosis, were compared between the two groups. Logistic regression analysis and receiving operating characteristic (ROC) curve were used to evaluate the relationship between circulating TBA and organ failure in AP patients.Results: Through stratified analysis of each time period, we found that the incidence of OF in the HTBA group was significantly higher than that in the NTBA group, and the AP severity classification in the HTBA group was more serious than that in the NTBA group. In addition, according to the D7 TBAmax values, the pancreatic necrosis rate, percutaneous catheter drainage (PCD) rate and mortality in the HTBA group were higher than those in the NTBA group. Multivariate regression analysis showed that HTBA (odds ratio (OR), 4.894; P = 0.002) was an independent risk factor for AP complicated with OF, which was verified in the grouping based on D7 TBAmax. ROC analysis revealed that a circulating D7 TBAmax cutoff point of 6.450 umol/L had optimal predictive value for the development of OF in AP patients with an area under the curve of the ROC curve (AUCROC) of 0.777. Conclusions: The increase of circulating TBA in early stage of AP is independently related to organ failure, which indicates the adverse prognosis of AP patients.

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“…Acute pancreatitis (AP) caused approximately 275,000 hospitalizations in 2009 (more than a 2-fold increase since 1982), and it is the single most frequent gastrointestinal cause of hospital admissions in the United States (Peery et al 2012). The reason for this is its diverse aetiology and the unpredictable course of the disease (Maleszka et al 2017). The aetiology, pathogenesis, and progression of acute pancreatitis are the subjects of numerous experimental and clinical studies (Tomaszewska et al 2000).…”

Section: Introductionmentioning

confidence: 99%

“…The aetiology of AP, apart from alcohol abuse and cholelithiasis, may also include a vascular component responsible for pancreatic ischaemia (Tomaszewska et al 2000). However, the most frequent aetiology is cholelithiasis, which accounts for 30-60% of cases (Maleszka et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Effects of 1,3,4-thiadiazine compound with antidepressant properties in ligation model of acute pancreatitis

Sarapultsev¹,

Чупахин²,

Rantsev³

et al. 2018

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Based on hypotheses concerning the role of stress in acute pancreatitis development, the experimental approach for the decrease stress damage via the use the compound with proven antistress/neuroleptic action was conducted. The study was aimed to discover 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine hydrobromide (compound L-17) therapeutic action in experimental acute pancreatitis. The experimental model used was the ligation model. The trial was carried out on 50 male Wistar rats with average body weight 180-240 g. Histological picture of the pancreas was studied and biochemical and enzyme-immunoassays were carried out on the first and seventh days. The significant reduction in mortality on the background of L-17 compound administration was observed. While levels of all cytokines increased in induced experimental acute pancreatitis groups, the cytokine level rise was decreased when compound L-17 was administered. On the cellular level, the study revealed L-17's ability to prevent granulocytosis and decrease granulocytes infiltration to inflammatory foci. The decrease in inflammatory reaction magnitude and prevention of abscess formation in experimental acute pancreatitis accompanied by sistemic inflamamtion was due to L-17's ability to reduce neutrophilia and neutrophil entry into the injury zone.

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The Diagnostic Usefulness of Serum Total Bile Acid Concentrations in the Early Phase of Acute Pancreatitis of Varied Etiologies

Cited by 13 publications

References 24 publications

Predictors of acute pancreatitis with low elevation of serum amylase

Predictors of acute pancreatitis with low elevation of serum amylase

Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis

Effects of 1,3,4-thiadiazine compound with antidepressant properties in ligation model of acute pancreatitis

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