The Diagnostic Role of Adiponectin in Pulmonary Embolism

Abstract

Background and Aims. Pulmonary thromboembolism (PTE) is a frequent disease with difficult diagnosis and high mortality. Misdiagnosis occurs in 2/3 patients and mortality rates reach up to 30%. The aim of our study was to investigate the role of adiponectin used in emergency service in diagnosis of PTE. Materials and Methods. 95 patients with suspected PTE included in the study. Plasma adiponectin and D-dimer levels were measured and chest X-ray and multidetector row computed tomography scan obtained. Diagnosis was supported by vascular filling defect on tomography. Control group consisted of patients with suspected PTE and normal chest computed tomography findings. Results. Mean D-dimer level was 4241.66 ± 1082.98 ng/mL in patients and 2211.21 ± 1765.53 ng/mL in the control group (p ≤ 0.05). Mean adiponectin level was 5.46 ± 4.39 μg/mL in patients and 7.68 ± 4.67 μg/mL in the control group (p ≤ 0.05). Wells and Geneva scores were higher in patients compared to the control group. Conclusions. As a result, we conclude that lower adiponectin levels have an important role in the diagnosis of PTE.

Elevated leptin and decreased adiponectin independently predict the post-thrombotic syndrome in obese and non-obese patients

“…Adiponectin is suggested to have anti-aggregatory properties 24 , 33 . Patients with confirmed PE had lower adiponectin compared with the control group 25 .…”

“…Animal studies showed that leptin is associated with venous thrombosis and PE 23 , while adiponectin decreased platelet aggregation by promoting endothelial nitric oxide and attenuate oxidative/nitrative stress 24 . Lower adiponectin levels were observed among patients with confirmed PE 25 . Allison et al .…”

“…The study was powered to have a 80% chance of detecting a difference in adiponectin levels using an alpha value of 0.05, based on the values of adiponectin presented in a previous study 25 . Taking into account that about 20% of patients develops PTS, in order to demonstrate such a difference or greater, at least 166 patients were required in the control group and 42 patients in the PTS group.…”

Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis

“…In an observational study, Restituto et al (2010) found that adiponectin decreased platelet aggregation and activation and demonstrated Frontiers in Genetics frontiersin.org antithrombotic characteristics in metabolic syndrome patients. A retrospective study involving 95 patients with pulmonary embolism revealed that patients with pulmonary embolism had lower adiponectin levels than normal controls (Gul et al, 2016). Recent prospective cohort research also demonstrated that low adiponectin levels are associated with post-thrombotic syndrome, regardless of BMI (Mrozinska et al, 2018).…”