The Diagnostic Performance of Multiparametric Ultrasound in the Qualitative Assessment of Inconclusive Cervical Lymph Nodes
Katharina Margherita Wakonig,
Steffen Dommerich,
Thomas Fischer
et al.
Abstract:Background: Enlarged cervical lymph nodes (CLNs) can result from infection or malignancies, and a definitive diagnosis requires histological examination. Ultrasound (US) remains the first-line imaging modality for detection, and new US techniques may improve characterization. The aim of our study was to investigate whether the qualitative assessment of multiparametric US (mpUS) can improve diagnostic performance in the differentiation of benign and malignant CLNs. Methods: 107 CLNs in 105 patients were examine… Show more
“…As we all know, most cervical metastatic LNs from PTC will have abnormal distribution of feeding vessels, which is often one of the important indicators to predict metastatic LNs [13,21] . In this study, CDFI and SMI in benign LNs were dominated by central portal type, while peripheral type was rare.…”
Background
To explore the diagnostic value of superb microvascular imaging (SMI) for ultrasonically uncertain lymph nodes (LNs).
Methods
Our center prospectively collected clinical and imaging data of 74 patients who underwent fine-needle aspiration biopsy and thyroglobulin measurement from January 2022 to June 2022. First, univariate analysis was performed to obtain relevant variables that differed between benign and malignant LN groups. Then spearman correlation was used to analyze the correlation between effective variables and pathological results. Finally, receiver operating characteristic was used to analyze the diagnostic efficiency of effective variables.
Results
In this study, there were 43 benign LNs and 31 malignant LNs. In univariate analysis, gender, age, CDFI diagnosis results and SMI diagnosis results were significantly different in the differentiation of benign and malignant LNs (P = 0.026, P = 0.041, P = 0.001, P < 0.001). CDFI and SMI diagnosis results had good correlated with pathological findings (r = 0.403, P < 0.001, r = 0.707, P < 0.001). The diagnostic efficiency of SMI (AUC = 0.856, P < 0.001) was higher than that of CDFI (AUC = 0.704, P = 0.003). And the diagnostic results of SMI were superior to those of CDFI. The number of feeding vessels showed by CDFI and SMI in malignant LNs was higher than that in benign LNs (2.00 vs. 1.00, 3.00 vs. 2.00, all P < 0.001). In all enrolled LNs, SMI showed significantly more vessels than CDFI (2.53 ± 1.47 vs. 1.50 ± 1.13, P < 0.001).
Conclusions
SMI is better than CDFI in displaying small feeding vessels and has important diagnostic value in judging the nature of LNs with ultrasound uncertainty.
“…As we all know, most cervical metastatic LNs from PTC will have abnormal distribution of feeding vessels, which is often one of the important indicators to predict metastatic LNs [13,21] . In this study, CDFI and SMI in benign LNs were dominated by central portal type, while peripheral type was rare.…”
Background
To explore the diagnostic value of superb microvascular imaging (SMI) for ultrasonically uncertain lymph nodes (LNs).
Methods
Our center prospectively collected clinical and imaging data of 74 patients who underwent fine-needle aspiration biopsy and thyroglobulin measurement from January 2022 to June 2022. First, univariate analysis was performed to obtain relevant variables that differed between benign and malignant LN groups. Then spearman correlation was used to analyze the correlation between effective variables and pathological results. Finally, receiver operating characteristic was used to analyze the diagnostic efficiency of effective variables.
Results
In this study, there were 43 benign LNs and 31 malignant LNs. In univariate analysis, gender, age, CDFI diagnosis results and SMI diagnosis results were significantly different in the differentiation of benign and malignant LNs (P = 0.026, P = 0.041, P = 0.001, P < 0.001). CDFI and SMI diagnosis results had good correlated with pathological findings (r = 0.403, P < 0.001, r = 0.707, P < 0.001). The diagnostic efficiency of SMI (AUC = 0.856, P < 0.001) was higher than that of CDFI (AUC = 0.704, P = 0.003). And the diagnostic results of SMI were superior to those of CDFI. The number of feeding vessels showed by CDFI and SMI in malignant LNs was higher than that in benign LNs (2.00 vs. 1.00, 3.00 vs. 2.00, all P < 0.001). In all enrolled LNs, SMI showed significantly more vessels than CDFI (2.53 ± 1.47 vs. 1.50 ± 1.13, P < 0.001).
Conclusions
SMI is better than CDFI in displaying small feeding vessels and has important diagnostic value in judging the nature of LNs with ultrasound uncertainty.
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