The diagnostic performance of automated versus handheld breast ultrasound and mammography in symptomatic outpatient women: a multicenter, cross-sectional study in China

Lin, Xi; Jia, Mengmeng; Zhou, Xiang; Bao, Liang; Chang, Yaqing; Liu, Peifang; Feng, Ruimei; Zhang, Xi; Zhu, Lei; Wang, Hui; Zhu, Ying; Tang, Guoxue; Feng, Wei; Liu, Lixian; Qiao, You‐Lin

doi:10.1007/s00330-020-07197-7

Cited by 18 publications

(18 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study demonstrates that ultrasound performed better or at least not worse than mammography in real-world settings, with higher sensitivity and specificity in high-risk Chinese women, as has been consistently shown in previous studies ( 13 , 22 ). However, it is contrary to screening performed in Western countries ( 7 , 23 ).…”

Section: Discussionsupporting

confidence: 87%

“…A study found that the sensitivity values for the experienced readers and inexperienced readers were 91.7% and 66.7%, respectively (28). Recently, researchers have been paying considerable attention to the automated breast ultrasound system (ABUS), which has also been named three-dimensional ultrasonography (22,(29)(30)(31). Unlike traditional hand-held ultrasound, ABUS has a reproducible and less operatordependent process for imaging acquisition and image interpretation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Different Breast Cancer Screening Strategies for High-Risk Women in Beijing, China: A Real-World Population-Based Study

et al. 2021

Self Cite

View full text Add to dashboard Cite

BackgroundMammography-based breast cancer screening has been widely implemented in many developed countries. Evidence was needed on participation and diagnostic performance of population-based breast cancer screening using ultrasound in China.MethodsWe used data from the Cancer Screening Program in Urban China in Beijing from 2014 to 2019 and was followed up until July 2020 by matching with the Beijing Cancer Registry database. Eligible women between the ages of 45 and 69 years were recruited from six districts and assessed their risk of breast cancer through an established risk scoring system. Women evaluated to be at high risk of breast cancer were invited to undergo both ultrasound and mammography. Participation rates were calculated, and their associated factors were explored. In addition, the performance of five different breast cancer screening modalities was evaluated in this study.ResultsA total of 49,161 eligible women were recruited in this study. Among them, 15,550 women were assessed as high risk for breast cancer, and 7,500 women underwent ultrasound and/or mammography as recommended, with a participation rate of 48.2%. The sensitivity of mammography alone, ultrasound alone, combined of ultrasound and mammography, ultrasound for primary screening followed by mammography for triage, and mammography for preliminary screening followed by ultrasound for triage were19.2%, 38.5%, 50.0%, 46.2%, and 19.2%, and the specificity were 96.1%, 98.6%, 94.7%, 97.6%, 95.7%, respectively. The sensitivity of combined ultrasound and mammography, ultrasound for primary screening followed by mammography for triage, was significantly higher than mammography alone (p=0.008 and p=0.039). Additionally, ultrasound alone (48,323 RMB ($7,550)) and ultrasound for primary screening followed by mammography for triage (55,927 RMB ($8,739)) were the most cost-effective methods for breast cancer screening than other modalities.ConclusionsUltrasound alone and ultrasound for primary screening and mammography are superior to mammography for breast cancer screening in high-risk Chinese women.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Evaluation of Different Breast Cancer Screening Strategies for High-Risk Women in Beijing, China: A Real-World Population-Based Study

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…In several studies, ABVS presents similar diagnostic accuracy and detection rate of HHUS [ 8 , 18 , 19 , 20 , 21 ]. In other studies, ABVS had significantly higher specificity and positive predictive value than HHUS [ 22 , 23 ]. This is the first study in literature where ABVS had a worse diagnostic performance than HHUS.…”

Section: Discussionmentioning

confidence: 74%

A Prospective Comparative Evaluation of Handheld Ultrasound Examination (HHUS) or Automated Ultrasound Examination (ABVS) in Women with Dense Breast

Brunetti

Giorgis²,

Tosto³

et al. 2022

Diagnostics

View full text Add to dashboard Cite

Mammography is the gold standard examination for breast cancer screening. In women with high breast density, mammography has reduced sensitivity. In these women, an additional screening option is often recommended. This study prospectively compared ABVS and HHUS in women with mammography-negative examinations and dense breasts. Materials and methods: N = 222 women were evaluated prospectively and consecutively between January 2019 and June 2019 (average age 53 years; range 39–89). McNemar’s test and ROC analysis were used with standard statistical software. We included in the study both symptomatic and asymptomatic women with dense breasts. Women included underwent both HHUS and ABVS after mammography with independent reading. Results: N = 33/222 (15%) women resulted in having breast cancer. Both ABVS and HHUS identified more cancers than standard mammography, and both HHUS and ABVS had false-positive examinations: n = 13 for HHUS and n = 12 for ABVS. We found that HHUS had better accuracy than ABVS. The AUC of the ROC was 0.788 (95% CI 0.687–0.890) for ABVS and 0.930 (95% CI 0.868–0.993) for HHUS. This difference was statistically significant (p < 0.05). Conclusions: HHUS was more accurate in breast cancer detection than ABVS. Multicentric studies must confirm these data for supplemental imaging in women with dense breasts.

show abstract

“…However, reading ABUS images is time consuming in the current clinical environment. It also requires high skill level for radiologists, which has limited ABUS integration into clinical practice (9)(10)(11)(12)(13). Gratifyingly, its standardization of screening made it possible to integrate computer-aided diagnosis (CAD) systems with this new imaging technology.…”

Section: Introductionmentioning

confidence: 99%

Improved Inception V3 method and its effect on radiologists’ performance of tumor classification with automated breast ultrasound system

Zhang

et al. 2021

Gland Surg

View full text Add to dashboard Cite

Background: The automated breast ultrasound system (ABUS) is recognized as a valuable detection tool in addition to mammography. The purpose of this study was to propose a novel computer-aided diagnosis (CAD) system by extracting the textural features from ABUS images and to investigate the efficiency of using this CAD for breast cancer detection.Methods: This retrospective study involved 149 breast nodules [maximum diameter: mean size 18.89 mm, standard deviation (SD) 10.238, and range 5-59 mm] in 135. We assigned 3 novice readers (<3 years of experience and 3 experienced readers (≥10 years of experience to review the imaging data and stratify the 149 breast nodules as either malignant or benign. The Improved Inception V3 (II3) method was developed and used as an assistant tool to help the 6 readers to re-interpret the images.Results: Our method (II3) achieved an accuracy of 88.6% for the final result. The 3 novice readers had an average accuracy of 71.37%±4.067% while the 3 experienced readers was 83.03%±3.371% on the firstreading. With the help of II3 on the second-reading, the average accuracy of the novice readers increased to 84.13%±1.662% and the experienced readers increased to 89.50%±0.346%.The areas under the curve (AUCs) were similar compared with linear algorithms. The mean AUC of the novice readers was improved from 0.7751 (without II3) to 0.8232 (with II3). The mean AUC of the experienced readers was improved from 0.8939 (without II3) to 0.9211 (with II3). The mean AUC for all readers improved in both the secondreading mode (from 0.8345 to 0.8722, P=0.0081<0.05).Conclusions: With the help of the II3, the diagnostic accuracy of the two groups were both improved, and II3 was more helpful for novice readers than for experienced readers. Our results showed that II3 is valuable in the differentiation of benign and malignant breast nodules and it also improves the experience and skill of some novice radiologists. The II3 cannot completely replace the influence of experience in the diagnostic process and will retain an auxiliary role in the clinic at present.

show abstract

The diagnostic performance of automated versus handheld breast ultrasound and mammography in symptomatic outpatient women: a multicenter, cross-sectional study in China

Cited by 18 publications

References 35 publications

Evaluation of Different Breast Cancer Screening Strategies for High-Risk Women in Beijing, China: A Real-World Population-Based Study

Evaluation of Different Breast Cancer Screening Strategies for High-Risk Women in Beijing, China: A Real-World Population-Based Study

A Prospective Comparative Evaluation of Handheld Ultrasound Examination (HHUS) or Automated Ultrasound Examination (ABVS) in Women with Dense Breast

Improved Inception V3 method and its effect on radiologists’ performance of tumor classification with automated breast ultrasound system

Contact Info

Product

Resources

About