The diagnostic efficacy of diffusion tensor imaging generated by gadolinium-based magnetic resonance imaging for patients with chronic kidney disease

Abstract

Background: Chronic kidney disease (CKD) can lead to systemic inflammatory responses and other cardiovascular disease. Diffusion tensor imaging findings generated by gadolinium-based MRI (DTI-GBMRI) is regarded as a standard method for assessing the pathology of CKD. To evaluate the diagnostic value of DTI-GBMRI for renal histopathology and renal efficiency, renal fibrosis and damage, noninvasive quantification of renal blood flow (RBF) were investigated in patients with CKD.Methods: CKD patients (n = 186) were recruited and underwent diagnosis of renal diffusion tensor imaging findings generated by MRI (DTI-MRI) or DTI-GBMRI to identify the pathological characteristics and depict renal efficiency. The cortical RBFs and estimated glomerular filtration rate were compared in CKD patients undergone DTI-GBMRI (n = 92) or DTI-MRI (n = 94).Results: Gadolinium enhanced the diagnosis generated by DTI-MRI in renal fibrosis, renal damage, and estimated glomerular filtration rate. The superiority in sensitivity and accuracy of the DTI-GBMRI method in assessing renal function and evaluating renal impairment was observed in CKD patients compared with DTI-MRI. Outcomes demonstrated that DTI-GBMRI had higher accuracy, sensitivity, and specificity than DTI-MRI in diagnosing patients with CKD. Conclusion:In conclusion, DTI-GBMRI is a potential noninvasive method for measuring renal function, which can provide valuable information for clinical CKD diagnosis.Abbreviations: ASCVD = atherosclerotic cardiovascular disease, BP = blood pressure, CEUS = contrast-enhanced ultrasound, CKD = chronic kidney disease, CMR = cardiovascular magnetic resonance, CNR = contrast-to-noise ratio, CT = computed tomography, DTI-GBMRI = diffusion tensor imaging findings generated by gadolinium-based MRI, DTI-MRI = diffusion tensor imaging findings generated by MRI, eGFR = estimated glomerular filtration rate, GB = gadolinium, MRI = magnetic resonance imaging, MTT = mean transit time, RBF = renal blood flow, ROC = receptor operating characteristics, US = ultrasonography.

Noninvasive diagnosis of interstitial fibrosis in chronic kidney disease: a systematic review and meta-analysis

“…However, for the diagnosis of early and mild fibrosis, using SWE as an example, there is not yet a consensus among centers on the diagnostic threshold of parameters. Eight studies [ 7 , 23 , 26 , 28 , 31 , 34–36 ] utilized MRI techniques to detect RF, and commonly used techniques, such as diffusion-weighted imaging/apparent diffusion coefficient (DWI/ADC), intravoxel incoherent motion (IVIM), diffusion tensor imaging (DTI), and gadolinium-enhanced imaging, were compared with pathological diagnoses to assess the severity of fibrosis. The studies suggested that MRI was more effective in assessing moderate to severe fibrosis.…”