The Diagnostic and Prognostic Value of miR-155 in Cancers: An Updated Meta-analysis

Wu, Yanan; Hong, Qiwei; Liu, Feng; Zhang, Zhongqiu; Li, Jingjing; Wang, Zhenlin; He, Bangshun

doi:10.1007/s40291-023-00641-6

Cited by 11 publications

(9 citation statements)

References 150 publications

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“…The study of miRNA holds promise. Different systematic reviews have also concluded that they are potential biomarkers for OSCC and OPMDs [ 11 , 72 , 73 ]. The main issue is, as with many of the other markers, is that apart from mir-21, which was assessed by two studies [ 47 , 48 ], the salivary expression of all other miRNAs, has been analyzed by single studies.…”

Section: Discussionmentioning

confidence: 99%

Salivary Biomarkers for Oral Cancer Detection: An Exploratory Systematic Review

Bastías,

Maturana,

Marín

et al. 2024

IJMS

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Different efforts have been made to find better and less invasive methods for the diagnosis and prediction of oral cancer, such as the study of saliva as a source of biomarkers. The aim of this study was to perform a scoping review about salivary molecules that have been assessed as possible biomarkers for the diagnosis of oral squamous cell carcinoma (OSCC). A search was conducted using EBSCO, PubMed (MEDLINE), Scopus, and Web of Science. The research question was as follows: which molecules present in saliva have utility to be used as biomarkers for the early detection of oral cancer? Sixty-two studies were included. Over 100 molecules were assessed. Most of the markers were oriented towards the early diagnosis of OSCC and were classified based on their ability for detecting OSCC and oral potentially malignant disorders (OPMDs), OSCC outcome prediction, and the prediction of the malignant transformation of OPMDs. TNF-α, IL-1β, IL-6 IL-8, LDH, and MMP-9 were the most studied, with almost all studies reporting high sensitivity and specificity values. TNF-α, IL-1β, IL-6 IL-8, LDH, and MMP-9 are the most promising salivary biomarkers. However, more studies with larger cohorts are needed before translating the use of these biomarkers to clinical settings.

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Section: Discussionmentioning

confidence: 99%

Salivary Biomarkers for Oral Cancer Detection: An Exploratory Systematic Review

Bastías,

Maturana,

Marín

et al. 2024

IJMS

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“…Therefore, further studies incorporating more standardized methodological approaches are warranted to explore the prognostic role of tissue miR-21-5p and miR-155-5p in BC, particularly using TCGA data. Besides TCGA-based studies, different authors have analyzed the association of tissue miR-21-5p and miR-155-5p with BC prognosis [ 105 , 106 , 107 ]. A recent meta-analysis conducted by Bahramy and colleagues demonstrated a significant association between poor overall survival and miR-21-5p expression in BC tissues (HR = 1.93 [95% CI: 1.62–2.30] p = 0.02) [ 105 ].…”

Section: Discussionmentioning

confidence: 99%

Unlocking the Potential of Circulating miRNAs in the Breast Cancer Neoadjuvant Setting: A Systematic Review and Meta-Analysis

Tiberio

Gaudio

Belloni

et al. 2023

Cancers

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The potential role of circulating microRNAs (miRNAs) as biomarkers in breast cancer (BC) management has been widely reported. However, the numerous discrepancies between studies in this regard hinders the implementation of circulating miRNAs in routine clinical practice. In the context of BC patients undergoing neoadjuvant chemotherapy (NAC), the possibility of predicting NAC response may lead to prognostic improvements by individualizing post-neoadjuvant therapy. In this context, the present meta-analysis aims to clarify circulating miRNAs’ predictive role with respect to NAC response among BC patients. We conducted a comprehensive literature search on five medical databases until 16 February 2023. We pooled the effect sizes of each study by applying a random-effects model. Cochran’s Q test (p-level of significance set at 0.05) scores and I2 values were assessed to determine between-study heterogeneity. The PROBAST (Prediction Model Risk of Bias Assessment Tool) tool was used to evaluate the selected studies’ risk of bias. Overall, our findings support the hypothesis that circulating miRNAs, specifically miR-21-5p and miR-155-5p, may act as predictive biomarkers in the neoadjuvant setting among BC patients. However, due to the limited number of studies included in this meta-analysis and the high degrees of clinical and statistical heterogeneity, further research is required to confirm the predictive power of circulating miR-21-5p and miR-155-5p.

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“…In addition, dozens of meta-analyses are available on the prognostic role of single miRNA types (e.g., miR-21 [ 297 ], miR-181a/b [ 298 ], miR-20a [ 299 ], miR-155 [ 300 ]) or the entire group of miRNAs tested (e.g., miR-21, miR-215, miR-143-5p, miR-106a, and miR-145) in specific stages of CRC development [ 301 ]. Gao et al, in their meta-analysis, showed that the strongest markers of poor prognosis included high levels of miR-141 in blood (HR 2.52, 95% CI 1.68–3.77) and miR-224 in tissue (HR 2.12, 95% CI 1.04–4.34) [ 302 ].…”

Section: Methods To Assess Cell Proliferation In Colorectal Cancermentioning

confidence: 99%

Prognostic Biomarkers of Cell Proliferation in Colorectal Cancer (CRC): From Immunohistochemistry to Molecular Biology Techniques

Kasprzak

2023

Cancers

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Colorectal cancer (CRC) is one of the most common and severe malignancies worldwide. Recent advances in diagnostic methods allow for more accurate identification and detection of several molecular biomarkers associated with this cancer. Nonetheless, non-invasive and effective prognostic and predictive testing in CRC patients remains challenging. Classical prognostic genetic markers comprise mutations in several genes (e.g., APC, KRAS/BRAF, TGF-β, and TP53). Furthermore, CIN and MSI serve as chromosomal markers, while epigenetic markers include CIMP and many other candidates such as SERP, p14, p16, LINE-1, and RASSF1A. The number of proliferation-related long non-coding RNAs (e.g., SNHG1, SNHG6, MALAT-1, CRNDE) and microRNAs (e.g., miR-20a, miR-21, miR-143, miR-145, miR-181a/b) that could serve as potential CRC markers has also steadily increased in recent years. Among the immunohistochemical (IHC) proliferative markers, the prognostic value regarding the patients’ overall survival (OS) or disease-free survival (DFS) has been confirmed for thymidylate synthase (TS), cyclin B1, cyclin D1, proliferating cell nuclear antigen (PCNA), and Ki-67. In most cases, the overexpression of these markers in tissues was related to worse OS and DFS. However, slowly proliferating cells should also be considered in CRC therapy (especially radiotherapy) as they could represent a reservoir from which cells are recruited to replenish the rapidly proliferating population in response to cell-damaging factors. Considering the above, the aim of this article is to review the most common proliferative markers assessed using various methods including IHC and selected molecular biology techniques (e.g., qRT-PCR, in situ hybridization, RNA/DNA sequencing, next-generation sequencing) as prognostic and predictive markers in CRC.

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The Diagnostic and Prognostic Value of miR-155 in Cancers: An Updated Meta-analysis

Cited by 11 publications

References 150 publications

Salivary Biomarkers for Oral Cancer Detection: An Exploratory Systematic Review

Salivary Biomarkers for Oral Cancer Detection: An Exploratory Systematic Review

Unlocking the Potential of Circulating miRNAs in the Breast Cancer Neoadjuvant Setting: A Systematic Review and Meta-Analysis

Prognostic Biomarkers of Cell Proliferation in Colorectal Cancer (CRC): From Immunohistochemistry to Molecular Biology Techniques

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