The Diagnostic and Prognostic Value of a Dual-Tasking Paradigm in a Memory Clinic

Nielsen, Malene Schjønning; Simonsen, Anja Hviid; Siersma, Volkert; Hasselbalch, Steen G.; Hoegh, Peter

doi:10.3233/jad-161310

Cited by 28 publications

(48 citation statements)

References 45 publications

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“…2). This finding confirms that performing the dual task is helpful in finding a difference between the CN and MCI group, which is in accordance with previous literature [11,32].…”

Section: Gait and Syndrome Diagnosissupporting

confidence: 93%

Gait Disturbances are Associated with Increased Cognitive Impairment and Cerebrospinal Fluid Tau Levels in a Memory Clinic Cohort

Muurling

Rhodius-Meester

Pärkkä

et al. 2020

JAD

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Background: Gait analysis with accelerometers is a relatively inexpensive and easy to use method to potentially support clinical diagnoses of Alzheimer's disease and other dementias. It is not clear, however, which gait features are most informative and how these measures relate to Alzheimer's disease pathology. Objective: In this study, we tested if calculated features of gait 1) differ between cognitively normal subjects (CN), mild cognitive impairment (MCI) patients, and dementia patients, 2) are correlated with cerebrospinal fluid (CSF) biomarkers related to Alzheimer's disease, and 3) predict cognitive decline.

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“…2). This finding confirms that performing the dual task is helpful in finding a difference between the CN and MCI group, which is in accordance with previous literature [11,32].…”

Section: Gait and Syndrome Diagnosissupporting

confidence: 93%

Gait Disturbances are Associated with Increased Cognitive Impairment and Cerebrospinal Fluid Tau Levels in a Memory Clinic Cohort

Muurling

Rhodius-Meester

Pärkkä

et al. 2020

JAD

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“…the relative time difference between single-and dual-task performances, did not discriminate between any of the groups in the current study. In previous studies, dual-task cost has been found to discriminate between mild AD and healthy controls [46] and between MCI and healthy controls [19,29], and has shown inconsistent results when discriminating between dementia disorders and MCI [18,19], and was not able to discriminate between MCI and SCI [18]. It may be argued that dual-task cost cannot differentiate between transitional diagnoses, because it captures subtle pathological changes and is therefore better considered an indicator of imminent cognitive decline [50].…”

Section: Discussionmentioning

confidence: 99%

“…Such methods could be useful either as frontline screening tools or as diagnostic tools aimed at facilitating early and potentially more effective interventions. Different kinds of dual-task tests have been suggested for these purposes [9,18,19].…”

Section: Introductionmentioning

confidence: 99%

Dual-task tests discriminate between dementia, mild cognitive impairment, subjective cognitive impairment, and healthy controls – a cross-sectional cohort study

et al. 2020

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Background: Discrimination between early-stage dementia and other cognitive impairment diagnoses is central to enable appropriate interventions. Previous studies indicate that dual-task testing may be useful in such differentiation. The objective of this study was to investigate whether dual-task test outcomes discriminate between groups of individuals with dementia disorder, mild cognitive impairment, subjective cognitive impairment, and healthy controls. Methods: A total of 464 individuals (mean age 71 years, 47% women) were included in the study, of which 298 were patients undergoing memory assessment and 166 were cognitively healthy controls. Patients were grouped according to the diagnosis received: dementia disorder, mild cognitive impairment, or subjective cognitive impairment. Data collection included participants' demographic characteristics. The patients' cognitive test results and diagnoses were collected from their medical records. Healthy controls underwent the same cognitive tests as the patients. The mobility test Timed Up-and-Go (TUG single-task) and two dual-task tests including TUG (TUGdt) were carried out: TUGdt naming animals and TUGdt months backwards. The outcomes registered were: time scores for TUG single-task and both TUGdt tests, TUGdt costs (relative time difference between TUG single-task and TUGdt), number of different animals named, number of months recited in correct order, number of animals per 10 s, and number of months per 10 s. Logistic regression models examined associations between TUG outcomes pairwise between groups.

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“…This kind of information is seldom presented in research [24]. The only dual-task study found in which the quality of participants' performances was analysed; performances analyses categorised performances as normal, moderate deviation, or severe deviation, which was apparently based on observations at the same time as the testing occurred [50]. In that study, it was found that 98% of healthy controls, 62% of those with MCI, and 35% of those with Alzheimer's disease were categorised as having normal performance, which emphasizes the importance of paying attention to and managing these phenomena to improve the test validity.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, categorisation based on cautious analyses of TUGdt performances might be used as an outcome measure in its own right, since deviant performance can be associated with the progression from MCI to dementia [29]. It has been suggested that the qualitative evaluation of dual-tasking may outperform quantitative measures when it comes to differentiating between progressive and stable MCI [50], but this hypothesis still needs further investigation. It is preferable for such analyses to be based on video-recorded tests to ensure a high degree of reliability.…”

Section: Discussionmentioning

confidence: 99%

Timed Up-and-Go Dual-Task Testing in the Assessment of Cognitive Function: A Mixed Methods Observational Study for Development of the UDDGait Protocol

Cedervall

Stenberg

Åhman

et al. 2020

IJERPH

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New methods to screen for and identify early-stage dementia disorders are highly sought after. The purpose of this pilot study is to develop a study protocol for a dual-task test aimed at aiding the early detection of dementia disorders. We used the Timed Up-and-Go (TUG) test, which is a mobility task involving starting in a sitting position, standing up, walking three meters to cross a line on the floor, turning around, walking back and sitting down again. We combined TUG with the verbal task of naming different animals. Pilot study participants were 43 individuals with and without established dementia diagnoses who attended a clinic for memory assessment. Video-recorded test performances were systematically analysed. Deviant test performances concerning the interplay between test administration and participants’ responses to the assessment instructions were revealed and led to refinements being made to the final study protocol. Exploration of the dual-task test outcome measures in a sub-sample of 22 persons, ten with and twelve without dementia, indicated that step-length and number of named animals after the turning point of the dual-task test might constitute appropriate measures for examining this kind of sample. We concluded that the refined study protocol is feasible for testing individuals undergoing initial memory assessments and healthy controls. Follow-up studies with larger samples are being carried out and will bring new knowledge to this area of research. It may also provide an opportunity for further studies exploring possibilities for broad clinical implementation.

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The Diagnostic and Prognostic Value of a Dual-Tasking Paradigm in a Memory Clinic

Abstract: In our study, we found that patients with MCI and mild AD have increasing difficulties in dual-tasking compared to healthy elderly. Hence, the dual-tasking paradigm may be a potential complement in the diagnostic assessment in a typical clinical setting.

Cited by 28 publications

References 45 publications

Gait Disturbances are Associated with Increased Cognitive Impairment and Cerebrospinal Fluid Tau Levels in a Memory Clinic Cohort

Gait Disturbances are Associated with Increased Cognitive Impairment and Cerebrospinal Fluid Tau Levels in a Memory Clinic Cohort

Dual-task tests discriminate between dementia, mild cognitive impairment, subjective cognitive impairment, and healthy controls – a cross-sectional cohort study

Timed Up-and-Go Dual-Task Testing in the Assessment of Cognitive Function: A Mixed Methods Observational Study for Development of the UDDGait Protocol

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